Differential effects of steroids on vascular tone and smooth muscle cell Ca2+-homeostasis

1997 ◽  
Vol 25 (1) ◽  
pp. 112S-112S ◽  
Author(s):  
DIETRICH O. RUEHLMANN ◽  
TOBY R. CANNON ◽  
RON JACOB ◽  
GIOVANNI E. MANN
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Tone ◽  
Differential Effects

Role of smooth muscle cell mineralocorticoid receptor in vascular tone

2014 ◽  
Vol 467 (8) ◽  
pp. 1643-1650 ◽  
Author(s):  
Antoine Tarjus ◽  
Ekaterina Belozertseva ◽  
Huguette Louis ◽  
Soumaya El Moghrabi ◽  
Carlos Labat ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Mineralocorticoid Receptor ◽  
Vascular Tone

Eicosanoid blood vessel regulation in physiological and pathological states

2020 ◽  
Vol 134 (20) ◽  
pp. 2707-2727
Author(s):  
John D. Imig
Keyword(s):  
Arachidonic Acid ◽  
Smooth Muscle ◽  
Cardiovascular Diseases ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Vascular Function ◽  
Vascular Tone ◽  
Future Research

Abstract Arachidonic acid can be metabolized in blood vessels by three primary enzymatic pathways; cyclooxygenase (COX), lipoxygenase (LO), and cytochrome P450 (CYP). These eicosanoid metabolites can influence endothelial and vascular smooth muscle cell function. COX metabolites can cause endothelium-dependent dilation or constriction. Prostaglandin I2 (PGI2) and thromboxane (TXA2) act on their respective receptors exerting opposing actions with regard to vascular tone and platelet aggregation. LO metabolites also influence vascular tone. The 12-LO metabolite 12S-hydroxyeicosatrienoic acid (12S-HETE) is a vasoconstrictor whereas the 15-LO metabolite 11,12,15-trihydroxyeicosatrienoic acid (11,12,15-THETA) is an endothelial-dependent hyperpolarizing factor (EDHF). CYP enzymes produce two types of eicosanoid products: EDHF vasodilator epoxyeicosatrienoic acids (EETs) and the vasoconstrictor 20-HETE. The less-studied cross-metabolites generated from arachidonic acid metabolism by multiple pathways can also impact vascular function. Likewise, COX, LO, and CYP vascular eicosanoids interact with paracrine and hormonal factors such as the renin–angiotensin system and endothelin-1 (ET-1) to maintain vascular homeostasis. Imbalances in endothelial and vascular smooth muscle cell COX, LO, and CYP metabolites in metabolic and cardiovascular diseases result in vascular dysfunction. Restoring the vascular balance of eicosanoids by genetic or pharmacological means can improve vascular function in metabolic and cardiovascular diseases. Nevertheless, future research is necessary to achieve a more complete understanding of how COX, LO, CYP, and cross-metabolites regulate vascular function in physiological and pathological states.

Abstract 503: Smooth Muscle Cell Cytochrome B5 reductase expression modulates vascular tone

2018 ◽  
Vol 38 (Suppl_1) ◽  
Author(s):  
Brittany G Durgin ◽  
Scott A Hahn ◽  
Megan P Miller ◽  
Megan P Miller ◽  
Adam C Straub
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Tone ◽  
Cytochrome B5 ◽  
Cytochrome B5 Reductase
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