Polyamine acetylation and apoptosis

1996 ◽  
Vol 24 (2) ◽  
pp. 229S-229S
Author(s):  
Gayle S Lindsay ◽  
Heather M Wallace
Keyword(s):  
Polyamine Acetylation

Polyamine acetylation in the developing and aging mouse brain

1983 ◽  
Vol 1 (3) ◽  
pp. 179-185 ◽  
Author(s):  
José G. Ortiz ◽  
Ezio Giacobini ◽  
Thomas Schmidt-Glenewinkel
Keyword(s):  
Mouse Brain ◽  
Aging Mouse ◽  
Polyamine Acetylation

scholarly journals Polyamine Acetylation Modulates Polyamine Metabolic Flux, a Prelude to Broader Metabolic Consequences

2007 ◽  
Vol 283 (7) ◽  
pp. 4241-4251 ◽  
Author(s):  
Debora L. Kramer ◽  
Paula Diegelman ◽  
Jason Jell ◽  
Slavoljub Vujcic ◽  
Salim Merali ◽  
...  
Keyword(s):  
Metabolic Flux ◽  
Polyamine Acetylation

Changes in polyamine acetylation in human cancer cells

1990 ◽  
Vol 18 (6) ◽  
pp. 1091-1094 ◽  
Author(s):  
HEATHER M. WALLACE ◽  
CATHERINE S. COLEMAN
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Polyamine Acetylation

Polyamine acetylation in rat brain during N-ethyl-N-nitrosourea-induced cerebral carcinogenesis

1995 ◽  
Vol 97 (1) ◽  
pp. 123-128
Author(s):  
Angela Sessa ◽  
Patrizia Tunici ◽  
Antonio Perin
Keyword(s):  
Rat Brain ◽  
Polyamine Acetylation

scholarly journals Polyamine Analog Diethylnorspermidine Restricts Coxsackievirus B3 and Is Overcome by 2A Protease Mutation In Vitro

Viruses ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 310
Author(s):  
Bridget M. Hulsebosch ◽  
Bryan C. Mounce
Keyword(s):  
Coxsackievirus B3 ◽  
Site Mutation ◽  
Polyamine Biosynthesis ◽  
Polyamine Catabolism ◽  
Polyamine Analog ◽  
Polyamine Acetylation ◽  
2A Protease ◽  
Significant Disease

Enteroviruses, including Coxsackievirus B3 (CVB3), are pervasive pathogens that cause significant disease, including cardiomyopathies. Unfortunately, no treatments or vaccines are available for infected individuals. We identified the host polyamine pathway as a potential drug target, as inhibiting polyamine biosynthesis significantly reduces enterovirus replication in vitro and in vivo. Here, we show that CVB3 is sensitive to polyamine depletion through the polyamine analog diethylnorspermidine (DENSpm), which enhances polyamine catabolism through induction of polyamine acetylation. We demonstrate that CVB3 acquires resistance to DENSpm via mutation of the 2A protease, which enhances proteolytic activity in the presence of DENSpm. Resistance to DENSpm occurred via mutation of a non-catalytic site mutation and results in decreased fitness. These data demonstrate that potential for targeting polyamine catabolism as an antiviral target as well as highlight a potential mechanism of resistance.

1334 Pentylenetetrazol-induced kindlings stimulates polyamine acetylation in rat brain

1997 ◽  
Vol 28 ◽  
pp. S177
Author(s):  
Yasushi Hayashi ◽  
Junichi Tanaka ◽  
Hiroichi Imazu
Keyword(s):  
Rat Brain ◽  
Polyamine Acetylation

STRESS-INDUCED POLYAMINE ACETYLATION IN E. COLI

1991 ◽  
pp. 380
Author(s):  
E.W. Gerner ◽  
S.W. Carper ◽  
D. Willis ◽  
J. Fish ◽  
K. Manning ◽  
...  
Keyword(s):  
E Coli ◽  
Polyamine Acetylation
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