Insulin-like growth factor II/cation-independent mannose 6-phosphate receptor and lysosomal enzyme recognition

1996 ◽  
Vol 24 (1) ◽  
pp. 136-141 ◽  
Author(s):  
N. M. Dahms
Keyword(s):  
Growth Factor ◽  
Lysosomal Enzyme ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Mannose 6 Phosphate ◽  
Enzyme Recognition

scholarly journals Mouse mutants lacking the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor are impaired in lysosomal enzyme transport: comparison of cation-independent and cation-dependent mannose 6-phosphate receptor-deficient mice

1998 ◽  
Vol 330 (2) ◽  
pp. 903-908 ◽  
Author(s):  
Istvan SOHAR ◽  
David SLEAT ◽  
Chang-Gong LIU ◽  
Thomas LUDWIG ◽  
Peter LOBEL
Keyword(s):  
Growth Factor ◽  
Lysosomal Enzyme ◽  
Enzyme Activities ◽  
Lysosomal Enzymes ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Solid Tissues ◽  
Mannose 6 Phosphate ◽  
Deficient Mice

Two proteins have been implicated in the mannose 6-phosphate-dependent transport of lysosomal enzymes to lysosomes: the 300 kDa cation-independent and the 46 kDa cation-dependent mannose 6-phosphate receptors (CI- and CD-MPRs). The mammalian CI-MPR also mediates endocytosis and clearance of insulin-like growth factor II (IGF-II). Mutant mice that lack the CD-MPR are viable, mice that lack the CI-MPR accumulate high levels of IGF-II and usually die perinatally, whereas mice that lack both IGF-II and CI-MPR are viable. To investigate the relative roles of the MPRs in the targeting of lysosomal enzymes in vivo, we analysed the effect of a deficiency of either MPR on lysosomal enzyme activities in animals lacking IGF-II. In CD-MPR-deficient mice, most activities were relatively normal in solid tissues and some were marginally elevated in serum. In CI-MPR-deficient mice, some enzyme activities were moderately decreased in solid tissues and multiple enzymes were markedly elevated in serum. Finally, total levels of serum mannose 6-phosphorylated glycoproteins were ~ 45-fold and ~ 15-fold higher than wild type in CI- and CD-MPR-deficient mice respectively, and there were specific differences in the pattern of these proteins when comparing CI- and CD-MPR deficient animals. These results indicate that while lack of the CI-MPR appears to perturb lysosome function to a greater degree than lack of the CD-MPR, each MPR has distinct functions for the targeting of lysosomal enzymes in vivo.

scholarly journals The Kangaroo Cation-independent Mannose 6-Phosphate Receptor Binds Insulin-like Growth Factor II with Low Affinity

1999 ◽  
Vol 274 (38) ◽  
pp. 27076-27082 ◽  
Author(s):  
Catherine A. Yandell ◽  
Andrew J. Dunbar ◽  
John F. Wheldrake ◽  
Zee Upton
Keyword(s):  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Mannose 6 Phosphate

scholarly journals Dimerization of the Insulin-like Growth Factor II/Mannose 6-Phosphate Receptor

2000 ◽  
Vol 275 (25) ◽  
pp. 18647-18656 ◽  
Author(s):  
James C. Byrd ◽  
Jung H. Y. Park ◽  
Beverly S. Schaffer ◽  
Farideh Garmroudi ◽  
Richard G. MacDonald
Keyword(s):  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Mannose 6 Phosphate
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