The acute effects of a single dose of ethanol on biochemical indices of skeletal muscle composition: time course changes and comparison with the effects of endotoxin

1994 ◽  
Vol 22 (4) ◽  
pp. 447S-447S ◽  
Author(s):  
M. E. Reilly ◽  
A. Paice ◽  
H. Ansell ◽  
V. B. Patel ◽  
J. S. Marway ◽  
...  
2011 ◽  
Vol 90 (10) ◽  
pp. 2144-2152 ◽  
Author(s):  
E. Voslarova ◽  
P. Chloupek ◽  
P. Vosmerova ◽  
J. Chloupek ◽  
I. Bedanova ◽  
...  

2014 ◽  
Vol 37 (4) ◽  
pp. 429-439 ◽  
Author(s):  
Syed Hammad Raza ◽  
Muhammad Bilal Ahmad ◽  
Muhammad Arslan Ashraf ◽  
Fahad Shafiq

2018 ◽  
Vol 314 (1) ◽  
pp. R122-R134 ◽  
Author(s):  
Yufeng Zhang ◽  
Frances Humes ◽  
Gregory Almond ◽  
Andreas N. Kavazis ◽  
Wendy R. Hood

Mitochondria are hypothesized to display a biphasic response to reactive oxygen species (ROS) exposure. In this study, we evaluated the time course changes in mitochondrial performance and oxidative stress in house mice following X-irradiation. Forty-eight mice were equally divided among six groups, including a nonirradiated control and five experimental groups that varied in time between X-ray exposure and euthanasia (1 h and 1, 4, 7, and 10 days after X-irradiation). We measured parameters associated with mitochondrial respiratory function and ROS emission from isolated liver and skeletal muscle mitochondria and levels of oxidative damage and antioxidants in liver, skeletal muscle, and heart tissues. Mitochondrial function dropped initially after X-irradiation but recovered quickly and was elevated 10 days after the exposure. Hydrogen peroxide production, lipid peroxidation, and protein carbonylation showed inverse U-shaped curves, with levels returning to control or lower than control, 10 days after X-irradiation. Enzymatic antioxidants and markers for mitochondrial biogenesis exhibited a tissue-specific response after irradiation. These data provide the first chronological description of the mitohormetic response after a mild dose of irradiation and highlight the protective response that cells display to ROS exposure. This study also provides valuable information and application for future mitochondrial and oxidative stress studies in numerous physiological settings.


1997 ◽  
Vol 21 (5) ◽  
pp. 792
Author(s):  
Matthew E. Reilly ◽  
David Mantle ◽  
Peter J. Richardson ◽  
John Salisbury ◽  
Jenny Jones ◽  
...  

1969 ◽  
Vol 61 (3) ◽  
pp. 432-440 ◽  
Author(s):  
Ingvar Sjöholm ◽  
Gunnar Rydén

ABSTRACT The distribution of oxytocin in the kidneys, liver, uterus and skeletal muscle of the rat was followed during 10 min after intravenous injection of tritium labelled oxytocin. Oxytocin was found to be taken up and degraded mainly in the kidneys and the liver. After 150 seconds no intact oxytocin could be detected in these organs. The time course of the distribution of the radioactivity in the liver and the skeletal muscle showed no noteworthy characteristics, whereas a different course was found in the kidneys and in the uterus. In the kidneys, the radioactivity increased continuously from 60 to 200 seconds after the injection, indicating an accumulation of oxytocin or its metabolites in the kidneys. In the uterus a high initial uptake was observed, followed by a decrease of the radioactivity from 60 to 100 seconds after the injection. This distribution pattern was specific to oxytocin, since the uptake of tritiated tyrosine and tritiated water was almost constant during the same time period. These findings may indicate a preferential distribution of oxytocin to the uterus.


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