The effects of high monounsaturated and polyunsaturated fat diets on vascular endothelium and the coagulation system in non-insulin dependent diabetes mellitus- related to changes in lipid peroxidation?

1993 ◽  
Vol 21 (2) ◽  
pp. 103S-103S ◽  
Author(s):  
VERNON J PARFITT ◽  
MARGARET HOPTON ◽  
JANICE TABERNER ◽  
COLIN BOLTON ◽  
MARTIN HARTOG
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Peroxidation ◽  
Vascular Endothelium ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Coagulation System ◽  
Dependent Diabetes Mellitus ◽  
Polyunsaturated Fat ◽  
Insulin Dependent ◽  
Fat Diets

Antioxidant Status and Lipid Peroxidation in Type II Diabetes Mellitus with and without Complications

1996 ◽  
Vol 90 (4) ◽  
pp. 255-260 ◽  
Author(s):  
Ranjini K. Sundaram ◽  
Anusha Bhaskar ◽  
Selvamani Vijayalingam ◽  
Moopil Viswanathan ◽  
Rema Mohan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Reduced Glutathione ◽  
Thiobarbituric Acid ◽  
Insulin Dependent Diabetes Mellitus ◽  
Type Ii Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent

1. This study was conducted on 467 cases of non-insulin-dependent diabetes mellitus and 180 healthy controls. Lipid peroxidation products in plasma and erythrocytes were assayed as thiobarbituric acid reactive substances, along with the erythrocyte antioxidant enzymes, namely superoxide dismutase, catalase and glutathione peroxidase. In addition, scavenger vitamins A, C and E and reduced glutathione levels in blood were also measured. 2. Lipid peroxidation was significantly raised within the first 2 years of diagnosis, and superoxide dismutase, catalase, reduced glutathione and vitamins C and E were significantly lowered. 3. These changes were correlated with the duration of the disease and were of a higher magnitude with the development of complications. 4. The results suggest that the antioxidant deficiency and excessive peroxide-mediated damage may appear early on in non-insulin-dependent diabetes mellitus, before the development of secondary complications.

scholarly journals STUDY OF LIPID PEROXIDE AND LIPID PROFILE IN DIABETES MELLITUS

2020 ◽  
pp. 67-69
Author(s):  
Divya Sinha ◽  
S. R. Padmeodev ◽  
Debarshi Jana
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Peroxidation ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Fasting Blood Glucose ◽  
Lipid Peroxide ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent

The study was designed to find out the correlation between lipid peroxidation, lipoprotein levels to severity and complication of diabetes mellitus. Degree of lipid peroxidation was measured in terms of malondialdehyde (MDA) along with lipid profile and blood glucose in diabetes mellitus. It is categorised into insulin dependent diabetes mellitus (IDDM), non insulin dependent diabetes mellitus (NIDDM) and diabetes mellitus(DM) with complication. Total 112 known diabetic cases and 52 non-diabetic controls were studied. These cases were grouped as per the concentration of fasting blood glucose level i.e. controlled, poorly controlled, and uncontrolled group. There are significant increase in the lipid peroxide (MDA) and lipid profile except HDL cholesterol which is decreased, has been found in all groups as compared to controls. In NIDDM group lipid peroxidation was markedly increased than IDDM group and it was higher in DM with complications. Other finding observed was that the level of lipid peroxide increased as per the increase in concentration of blood glucose. The increase lipid peroxidation in the hyperglycemic condition may be explained, as the superoxide dismutase enzyme which is antioxidant becomes inactive due the formation of superoxide radical within the cell. Maximum lipid peroxidation leads to the damage of the tissue and organs which results into complication in diabetic cases. High levels of total cholesterol appear due to increased cholesterol synthesis. The triglyceride levels changes according to the glycemic control. The increase may be due to overproduction of VLDL-TG. It is concluded that good metabolic control of hyperglycemia will prevent in alteration in peroxidation and the lipid metabolism, which may help in good prognosis and preventing manifestation of vascular and secondary complication in diabetes mellitus

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