Characterization of a sodiummotive NADH: ubiquinone oxidoreductase

1992 ◽  
Vol 20 (3) ◽  
pp. 577-582 ◽  
Author(s):  
Roger M. Bourne ◽  
Peter R. Rich
Keyword(s):  
Ubiquinone Oxidoreductase ◽  
Nadh Ubiquinone Oxidoreductase

scholarly journals Synthesis and Characterization of New Piperazine-Type Inhibitors for Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex I)†

Biochemistry ◽  
2008 ◽  
Vol 47 (40) ◽  
pp. 10816-10826 ◽  
Author(s):  
Naoya Ichimaru ◽  
Masatoshi Murai ◽  
Nobuyuki Kakutani ◽  
Junko Kako ◽  
Atsushi Ishihara ◽  
...  
Keyword(s):  
Complex I ◽  
Synthesis And Characterization ◽  
Ubiquinone Oxidoreductase ◽  
Nadh Ubiquinone Oxidoreductase

scholarly journals The Na+-translocating NADH : ubiquinone oxidoreductase of Azotobacter vinelandii negatively regulates alginate synthesis

Microbiology ◽  
2009 ◽  
Vol 155 (1) ◽  
pp. 249-256 ◽  
Author(s):  
Cinthia Núñez ◽  
Alexander V. Bogachev ◽  
Gabriel Guzmán ◽  
Isaac Tello ◽  
Josefina Guzmán ◽  
...  
Keyword(s):  
Sodium Pump ◽  
Azotobacter Vinelandii ◽  
Soil Bacterium ◽  
Wild Type ◽  
Ubiquinone Oxidoreductase ◽  
Alginate Production ◽  
Isolation And Characterization ◽  
Nadh Ubiquinone Oxidoreductase ◽  
A Subunit

Azotobacter vinelandii is a nitrogen-fixing soil bacterium that produces the exopolysaccharide alginate. In this report we describe the isolation and characterization of A. vinelandii strain GG4, which carries an nqrE : : Tn5 mutation resulting in alginate overproduction. The nqrE gene encodes a subunit of the Na+-translocating NADH : ubiquinone oxidoreductase (Na+-NQR). As expected, Na+-NQR activity was abolished in mutant GG4. When this strain was complemented with the nqrEF genes this activity was restored and alginate production was reduced to wild-type levels. Na+-NQR may be the main sodium pump of A. vinelandii under the conditions tested (∼2 mM Na+) since no Na+/H+-antiporter activity was detected. Collectively our results indicate that in A. vinelandii the lack of Na+-NQR activity caused the absence of a transmembrane Na+ gradient and an increase in alginate production.

scholarly journals In vitro characterization of mitochondrial function and structure in rat and human cells with a deficiency of the NADH: ubiquinone oxidoreductase Ndufc2 subunit

2017 ◽  
Vol 26 (23) ◽  
pp. 4541-4555 ◽  
Author(s):  
Salvatore Raffa ◽  
Cristina Scrofani ◽  
Sabatino Valente ◽  
Andrea Micaloni ◽  
Maurizio Forte ◽  
...  
Keyword(s):  
Mitochondrial Function ◽  
Human Cells ◽  
Ubiquinone Oxidoreductase ◽  
In Vitro Characterization ◽  
Nadh Ubiquinone Oxidoreductase
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