Effects of pancuronium and vecuronium on plasma levels of lactate dehydrogenase and creatine kinase in patients undergoing gynaecological surgery

1991 ◽  
Vol 19 (4) ◽  
pp. 423S-423S
Author(s):  
Fadhil A. WALI ◽  
Victor MAKINDE ◽  
Alan MAHONEY ◽  
Hugh F. SEELEY
Keyword(s):  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Plasma Levels ◽  
Gynaecological Surgery

scholarly journals Ascorbic Acid Significantly Decreases Creatine Kinase Plasma Levels in an Animal Model of Statin/Fibrate-Induced Myopathy

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Mohsen Zabihi ◽  
Fatemeh Askarian ◽  
Seyedhossein Hekmatimoghaddam ◽  
Mohammadreza Rashidi Nooshabadi ◽  
Mohammad Sajjad Zabihi ◽  
...  
Keyword(s):  
Animal Model ◽  
Ascorbic Acid ◽  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Plasma Levels ◽  
Lipid Lowering ◽  
Blood Levels ◽  
Exercise Regimen ◽  
Muscular Disease ◽  
Vit C

Background. Myopathy is one of the side effects of lipid-lowering drugs, especially statins and particularly when combined with a fibrate. To diagnose myopathy and determine its severity, the plasma levels of three enzymes, creatine kinase (CK), aldolase, and lactate dehydrogenase (LDH), are routinely measured. Physical exercise can aggravate the statin-associated muscular disease. The question is whether antioxidants like ascorbic acid (Vit. C) can prevent such myopathy. Methods. In this experiment, a combination of atorvastatin (ATV, 80 mg/kg/day) and gemfibrozil (GMF, 1000 mg/kg/day) orally for 10 days as well as exercise as forced swimming on days 8, 9, and 10 were used to induce myopathy. Ascorbic acid (50 mg/kg/day, orally) was added to ATV/GMF plus exercise regimen throughout the 10 days in the treatment group. Mean blood levels of CK, aldolase, and LDH were measured in addition to swimming tolerance times. Results. There was a significantly higher swimming tolerance time P < 0.05 and lower CK levels P < 0.01 in rats receiving ATV/GMF/Vit. C plus exercise compared with rats not taking Vit. C. LDH and aldolase did not decrease significantly. Conclusion. The results of this study showed that Vit. C can be effective in preventing myopathy caused by fat-lowering drugs.

Preferential uptake of intravenously administered hyaluronidase (Hyalosidase) by damaged rat myocardium

1985 ◽  
Vol 5 (4) ◽  
pp. 329-334
Author(s):  
Julia S. Earnshaw ◽  
Kheng H. Peh ◽  
Kenneth S. Dodgson ◽  
Anthony H. Olavesen ◽  
Peter Gacesa
Keyword(s):  
Myocardial Infarction ◽  
Creatine Kinase ◽  
Coronary Artery ◽  
Lactate Dehydrogenase ◽  
Plasma Levels ◽  
Heart Tissue ◽  
Model System ◽  
Rat Myocardium ◽  
Normal Heart ◽  
Preferential Uptake

The induction of myocardial infarction in rats by ligation of the left – anterior coronary artery was confirmed by measurement of increased plasma levels of creatine kinase, aspartate aminotransferase and lactate dehydrogenase. Using this model system it has been established that intravenous administration of 12SI-labelled hyaluronidase to rats resulted in a preferential uptake of the enzyme by damaged myocardium as compared to normal heart tissue.

99mTc-Aminohexylidendiphosphonate and 99mTc-Pyrophos phate in the Scintigraphic Diagnosis of Experimental Cardiomyopathy in Dogs

1987 ◽  
Vol 26 (05) ◽  
pp. 220-223 ◽  
Author(s):  
L. Hadaš ◽  
J. VižĎa ◽  
P. Kafka ◽  
Y. Mazurová ◽  
V. Palicka ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Plasma Levels ◽  
Maximum Accumulation ◽  
Kinase A ◽  
Good Agreement

Experimental cardiomyopathy was provoked in 24 dogs with high intravenous doses of adrenaline and theophylline. These lesions were studied by means of the new agent 99mTc-AHDP and 99mTc-PYP in comparison. Cardiomyopathy could be imaged as early as 4 h after the onset of involvement but not later than 7 days. A maximum accumulation occurred in lesions 24 h old. 99mTc uptake in the myocardium was graded scintigraphically. 99mTc-AHDP was accumulated in the altered’myocardium to a greater extent than 99mTc-PYP. Scintigraphic findings were in good agreement with plasma levels of creatine- kinase. A comparison with histology demonstrated that the maximum accumulation of radiopharmaceuticals occurred at the time when the development of myocardium involvement reached the stage of myocytolysis.

EFFECT OF DRAFT LOAD ON LACTATE DEHYDROGENASE AND CREATINE KINASE ACTIVITIES IN MULES.(Equusasinus x Equuscaballus)

2016 ◽  
Vol 12 (1) ◽  
Author(s):  
A. Moolchandani ◽  
M. Sareen
Keyword(s):  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Serum Creatine Kinase

This study was carried out to assess the effects of draft load on serum creatine kinase and lactated ehydorgenase activities in mule. Five adult mules of 5 to 6 years of age were subjected to loading exercise (i.e. 10% draft load for 1 to 5 days and 20% draft load from 6th to 10th day). A highly significant (P<0.01) increase in serum LDH activities in response to 10% and 20% draft load exercise was observed while significant (P<0.05) increase at 10% draft load and highly significant (P<0.01) increase at 20% draft load was observed in CK activities.

Production and certification of secondary enzyme reference materials (ERMs). Part 1: Preparation of the sera and some of their properties.

1986 ◽  
Vol 32 (10) ◽  
pp. 1901-1905 ◽  
Author(s):  
J C Koedam ◽  
G M Steentjes ◽  
S Buitenhuis ◽  
E Schmidt ◽  
R Klauke
Keyword(s):  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Reference Material ◽  
Human Serum ◽  
Dehydrogenase Activity ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Glutamate Dehydrogenase Activity ◽  
The Stability ◽  
Clinical Enzymology

Abstract We produced three batches of a human-serum-based enzyme reference material (ERM) enriched with human aspartate aminotransferase (EC 2.6.1.1), alanine aminotransferase (EC 2.6.1.2), creatine kinase (EC 2.7.3.2), and lactate dehydrogenase (EC 1.1.1.27). The added enzymes were not exhaustively purified; thus the final ERMs contained some enzymes as contaminants, of which only glutamate dehydrogenase activity might interfere. The stability during storage and after reconstitution was good. The commutability of the four enzymes in the three ERM batches was also good, except when German or Scandinavian methods for aminotransferases were involved. The temperature-conversion factors for the ERMs were equivalent to those for patients' sera. Reactivation after reconstitution was complete within 5 min and was independent of the temperature of the reconstitution fluid. We believe that these secondary ERMs will aid in the transfer of accuracy between well-defined reference methods and daily working methods so that clinical enzymology results will become more comparable from laboratory to laboratory.

scholarly journals Local myotoxicity of ketamine hydrochloride in the marmoset

1987 ◽  
Vol 21 (1) ◽  
pp. 60-67 ◽  
Author(s):  
C. W. Davy ◽  
P. N. Trennery ◽  
J. G. Edmunds ◽  
J. F. B. Altman ◽  
D. A. Eichler
Keyword(s):  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Physical Properties ◽  
Aspartate Aminotransferase ◽  
Solution Ph ◽  
Histopathological Findings ◽  
Plasma Enzyme ◽  
Routine Blood ◽  
Ketamine Hydrochloride ◽  
Injection Procedure

An investigation of raised plasma aspartate aminotransferase (AST) in marmosets after intramuscular ketamine injection suggested a local myotoxicity. This was confirmed by a range of histopathological findings from myofibrillar striation loss to necrosis. In addition to the elevations in AST levels, creatine kinase and the lactate dehydrogenase-5 isoenzyme levels were elevated. It was further demonstrated that, although the physical properties of the injectable solution (pH, osmolality) and to a lesser extent the injection procedure itself caused slight changes in plasma enzyme levels, the ketamine was predominantly responsible for the lesion. No hepatic interactions were seen. This effect should be taken into consideration when this anaesthetic is used in the marmoset if the primary objectives of the experiment entail routine blood analyses.

ASSOCIATION OF SERUM LACTATE LEVELS WITH CREATINE KINASE – MB AND LACTATE DEHYDROGENASE IN PATIENTS WITH MYOCARDIAL INFARCTION

2021 ◽  
pp. 73-75
Author(s):  
Mallaiyan Manonmani ◽  
Meiyappan Kavitha
Keyword(s):  
Myocardial Infarction ◽  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Serum Lactate ◽  
Serum Creatine Kinase ◽  
Hemodynamic Management ◽  
Diagnosis And Prognosis ◽  
Creatine Kinase Mb ◽  
Enzymatic Markers ◽  
Lactate Levels

Objectives: Myocardial infarction is the most common form of coronary heart disease, the commonest cause of worldwide mortality. The present biochemical markers take atleast 6 hours for elevation following an episode of myocardial infarction. There is a need for sensitive marker for early diagnosis and prognosis. Lactate, the end product of anaerobic glycolysis is found to be elevated in many critical illnesses. Thus the study was undertaken to assess the levels of serum lactate in patients with myocardial infarction and to correlate it with the frequently used enzymatic markers for the diagnosis of myocardial infarction, i.e creatine kinase – MB and lactate dehydrogenase Methods: Fifty age and sex matched controls and fty cases of myocardial infarction were included in the study. Serum creatine kinase – MB, lactate dehydrogenase and lactate were estimated in these subjects. Results:The serum lactate levels were signicantly higher among cases when compared to controls. The serum lactate levels positively correlated with serum creatine kinase – MB among cases but not with lactate dehydrogenase. Conclusions: We conclude that serum lactate is altered in patients with myocardial infarction and may be considered as a prognostic risk factor in these patients. Further studies are needed to nd the cut-off value of serum lactate for assistance in the hemodynamic management of these patients.

scholarly journals Creatine Kinase and Lactate Dehydrogenase Responses After Different Resistance and Aerobic Exercise Protocols

2017 ◽  
Vol 58 (1) ◽  
pp. 65-72 ◽  
Author(s):  
Gustavo A. Callegari ◽  
Jefferson S. Novaes ◽  
Gabriel R. Neto ◽  
Ingrid Dias ◽  
Nuno D. Garrido ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Resistance Exercise ◽  
Aerobic Exercise ◽  
Aerobic Training ◽  
Body Height ◽  
Blood Samples ◽  
Set Protocol ◽  
Experimental Protocols ◽  
Elevate Plasma

AbstractThe aim of this study was to investigate the responses of creatine kinase (CK) and lactate dehydrogenase (LDH) after performing different resistance and aerobic exercise protocols. Twelve recreationally trained men (age, 23.2 ± 5.6 years; body mass, 84.3 ± 9.3 kg; body height, 178.9 ± 4.5 cm; and BMI, 26.3 ± 2.3 kg·m2) volunteered to participate in this study. All subjects were randomly assigned to four experimental protocols (crossover): (a) aerobic training at 60% of VO2max, (b) aerobic training at 80% of VO2max, (c) a resistance exercise (RE) session with a bi-set protocol, and (d) an RE session with a multiple sets protocol. Blood samples were collected before, immediately after and 24 hours following the experimental protocols. After 24 hours, there was a significant increase in CK for the 80% of VO2max protocol vs. the bi-set RE session (p = 0.016). Immediately after the protocols, we observed a significant increase in LDH among certain groups compared to others, as follows: multiple sets RE session vs. 60% of VO2max, bi-set RE session vs. 60% of VO2max, multiple sets RE session vs. 80% of VO2max, and bi-set RE session vs. 80% of VO2max (p = 0.008, p = 0.013; p = 0.002, p = 0.004, respectively). In conclusion, aerobic exercise performed at 80% of VO2max appears to elevate plasma CK levels more than bi-set RE sessions. However, the bi-set and multiple sets RE sessions appeared to trigger greater levels of blood LDH compared to aerobic protocols performed at 60% and 80% of VO2max.

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