Role of ligand in oestrogen-receptor function

1991 ◽  
Vol 19 (4) ◽  
pp. 897-899 ◽  
Author(s):  
M. G. Parker ◽  
S. E. Fawell ◽  
P. Danielian ◽  
N. Arbuckle
Keyword(s):  
Oestrogen Receptor ◽  
Receptor Function

scholarly journals Oestrogen receptors and antioestrogen treatment of hormone-dependent tumours

2018 ◽  
Vol 49 (2) ◽  
pp. 91
Author(s):  
N. G. KOSTOMITSOPOULOS (Ν.Γ. ΚΩΣΤΟΜΗΤΣΟΠΟΥΛΟΣ)
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Dna Sequences ◽  
Human Breast Cancer ◽  
Oestrogen Receptor ◽  
Specific Gene ◽  
Oestrogen Receptors ◽  
Human Breast ◽  
Potential Use

The oestrogen receptor is a ligand-activated transcription factor that modulates specific gene expression by binding to short DNA sequences. The study of the role of oestrogen receptor on the expression of the mitogenic actionof oestrogens and oncogenesis lead biomedical research in new approaches of the treatment of oestrogen-dependent tumors by using antioestrogens. Main mechanism of action of antioestrogens is the prevention of oestrogen action by blocking the binding of oestradiol to the oestrogen receptor. Tamoxifen, the most wellknown antioestrogen, is widely used as adjuvant therapy in all stages of human breast cancer. Recently interest is focused on the potential use of "pure" antioestrogens. The use of antioestrogens in veterinary oncology is also under discussion.

scholarly journals The Role of CHK1 Varies with the Status of Oestrogen-receptor and Progesterone-receptor in the Targeted Therapy for Breast Cancer

2020 ◽  
Vol 16 (8) ◽  
pp. 1388-1402
Author(s):  
Wei Xu ◽  
Minghua Huang ◽  
Jia Guo ◽  
Huiting Zhang ◽  
Depeng Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Targeted Therapy ◽  
Progesterone Receptor ◽  
Oestrogen Receptor ◽  
The Status

Role of Calmodulin in Platelet Receptor Function

2005 ◽  
Vol 3 (4) ◽  
pp. 283-287 ◽  
Author(s):  
E. Gardiner ◽  
J. Arthur ◽  
M. Berndt ◽  
R. Andrews
Keyword(s):  
Receptor Function ◽  
Platelet Receptor
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