Comparison of purified D2-dopamine receptor from bovine brain and pituitary gland

1990 ◽  
Vol 18 (3) ◽  
pp. 432-432
Author(s):  
P. L. CHAZOT ◽  
P. G. STRANGE
Keyword(s):  
Pituitary Gland ◽  
Dopamine Receptor ◽  
Bovine Brain ◽  
D2 Dopamine Receptor

scholarly journals Importance of thiol groups in ligand binding to D2 dopamine receptors from brain and anterior pituitary gland

1992 ◽  
Vol 281 (2) ◽  
pp. 377-380 ◽  
Author(s):  
P L Chazot ◽  
P G Strange
Keyword(s):  
Ligand Binding ◽  
Pituitary Gland ◽  
Dopamine Receptors ◽  
Dopamine Receptor ◽  
Thiol Group ◽  
Brain Regions ◽  
Subsequent Treatment ◽  
D2 Dopamine Receptor ◽  
Receptor Binding Site ◽  
D2 Dopamine Receptors

The effects of the thiol group reagent 5,5′-dithiobis-(2-nitrobenzoic acid) (DTNB) on D2 dopamine receptors have been examined in three brain regions (caudate nucleus, putamen and olfactory tubercle), and in the anterior and neurointermediate lobes of the pituitary gland. Whereas the receptors in brain were insensitive to DTNB, a dose-dependent inhibition of [3H]spiperone binding to D2 receptors in both lobes of the pituitary gland was observed. The effects in the pituitary could be reversed by subsequent treatment with dithiothreitol and could be prevented by prior occupancy of the receptor binding site with a ligand. The effect of DTNB was to decrease the number of ligand-binding sites without altering the affinity of those remaining. The results show that modification of a thiol group of the D2 dopamine receptor in the two lobes of the pituitary gland tested here significantly affects ligand binding. There is therefore a difference between the D2 dopamine receptor populations in brain and pituitary in their sensitivity to modification by DTNB, and this may imply the existence of different receptor isoforms in the two issues.

Role of trace amine associated receptor 1 (TAAR1) in D2 dopamine receptor-related behavior and signaling

2012 ◽  
Author(s):  
S. Espinoza ◽  
F. Manago ◽  
M. Messa ◽  
T. D. Sotnikova ◽  
M. Caron ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
D2 Dopamine Receptor ◽  
Trace Amine

Role of Trace Amine Associated Receptor 1 (TAAR1) in D2 Dopamine receptor-related behavior and signaling

2012 ◽  
Author(s):  
S. Espinoza ◽  
F. Manago ◽  
M. Messa ◽  
T. D. Sotnikova ◽  
M. Caron ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
D2 Dopamine Receptor ◽  
Trace Amine

The effect of ionic environments on the affinity of D2-dopamine receptor radioligands

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S616-S616
Author(s):  
Christine A Parker ◽  
Julian C Matthews ◽  
John Brown ◽  
Antony D Gee ◽  
Eugenii A Rabiner
Keyword(s):  
Dopamine Receptor ◽  
D2 Dopamine Receptor

Effects of D2 dopamine receptor activation in the ventral pallidum on sensory gating and food-motivated learning in control and schizophrenia model (Wisket) rats

2021 ◽  
Vol 400 ◽  
pp. 113047
Author(s):  
László Péczely ◽  
Gabriella Kékesi ◽  
Veronika Kállai ◽  
Tamás Ollmann ◽  
Kristóf László ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Sensory Gating ◽  
Receptor Activation ◽  
Ventral Pallidum ◽  
D2 Dopamine Receptor

Uptake and distribution of fluorescein-labeled D2 dopamine receptor antisense oligodeoxynucleotide in mouse brain

1996 ◽  
Vol 7 (1) ◽  
pp. 13-28 ◽  
Author(s):  
Sui-Po Zhang ◽  
Long-Wu Zhou ◽  
Mark Morabito ◽  
Rick C. S. Lin ◽  
Benjamin Weiss
Keyword(s):  
Dopamine Receptor ◽  
Mouse Brain ◽  
Antisense Oligodeoxynucleotide ◽  
D2 Dopamine Receptor
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