Monoclonal antibody 1.4D1 detects a glycoprotein secreted by adult human skin fibroblasts

1990 ◽  
Vol 18 (2) ◽  
pp. 278-279
Author(s):  
W. H. IRWIN McLEAN ◽  
BRENDAN J. FOGARTY ◽  
NORMAN C. NEVIN
Keyword(s):  
Monoclonal Antibody ◽  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Adult Human ◽  
Adult Human Skin

The differential proliferative response of fetal and adult human skin fibroblasts to TGF-β is retained when cultured in the presence of fibronectin or collagen

2014 ◽  
Vol 1840 (8) ◽  
pp. 2635-2642 ◽  
Author(s):  
Andreas A. Armatas ◽  
Harris Pratsinis ◽  
Eleni Mavrogonatou ◽  
Maria T. Angelopoulou ◽  
Anastasios Kouroumalis ◽  
...  
Keyword(s):  
Human Skin ◽  
Proliferative Response ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Adult Human ◽  
Adult Human Skin

scholarly journals Hyaluronan uptake by adult human skin fibroblasts in vitro

10.4081/808 ◽  
2009 ◽  
Vol 47 (1) ◽  
pp. 63 ◽  
Author(s):  
MA Croce ◽  
F Boraldi ◽  
D Quaglino ◽  
R Tiozzo ◽  
I Pasquali-Ronchetti
Keyword(s):  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Adult Human ◽  
Adult Human Skin

scholarly journals Attenuation of PRRX2 and HEY2 enables efficient conversion of adult human skin fibroblasts to neurons

2019 ◽  
Vol 516 (3) ◽  
pp. 765-769 ◽  
Author(s):  
Hanqin Li ◽  
Houbo Jiang ◽  
Xinzhen Yin ◽  
Jonathan E. Bard ◽  
Baorong Zhang ◽  
...  
Keyword(s):  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Adult Human ◽  
Efficient Conversion ◽  
Adult Human Skin

Fetal and adult human skin fibroblasts display intrinsic differences in contractile capacity

2001 ◽  
Vol 188 (2) ◽  
pp. 211-222 ◽  
Author(s):  
V�ronique Moulin ◽  
Betty Y.Y. Tam ◽  
Gilbert Castilloux ◽  
Fran�ois A. Auger ◽  
Maureen D. O'Connor-McCourt ◽  
...  
Keyword(s):  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Adult Human ◽  
Adult Human Skin

scholarly journals Brief demethylation step allows the conversion of adult human skin fibroblasts into insulin-secreting cells

2013 ◽  
Vol 110 (22) ◽  
pp. 8948-8953 ◽  
Author(s):  
G. Pennarossa ◽  
S. Maffei ◽  
M. Campagnol ◽  
L. Tarantini ◽  
F. Gandolfi ◽  
...  
Keyword(s):  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Adult Human ◽  
Insulin Secreting Cells ◽  
Adult Human Skin

Comparative study of adult human skin fibroblasts and umbilical fibroblast-like cells

2006 ◽  
Vol 141 (1) ◽  
pp. 161-166 ◽  
Author(s):  
K. N. Yarygin ◽  
Yu. G. Suzdal’tseva ◽  
V. V. Burunova ◽  
A. V. Voronov ◽  
N. V. Petrakova ◽  
...  
Keyword(s):  
Comparative Study ◽  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Adult Human ◽  
Adult Human Skin

scholarly journals Aging-relevant human basal forebrain cholinergic neurons as a cell model for Alzheimer’s disease

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Shuaipeng Ma ◽  
Tong Zang ◽  
Meng-Lu Liu ◽  
Chun-Li Zhang
Keyword(s):  
Human Skin ◽  
Basal Forebrain ◽  
Cell Model ◽  
Cholinergic Neurons ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Adult Human ◽  
Basal Forebrain Cholinergic Neurons ◽  
Induced Neurons ◽  
Adult Human Skin

Abstract Background Alzheimer’s disease (AD) is an adult-onset mental disorder with aging as a major risk factor. Early and progressive degeneration of basal forebrain cholinergic neurons (BFCNs) contributes substantially to cognitive impairments of AD. An aging-relevant cell model of BFCNs will critically help understand AD and identify potential therapeutics. Recent studies demonstrate that induced neurons directly reprogrammed from adult human skin fibroblasts retain aging-associated features. However, human induced BFCNs (hiBFCNs) have yet to be achieved. Methods We examined a reprogramming procedure for the generation of aging-relevant hiBFCNs through virus-mediated expression of fate-determining transcription factors. Skin fibroblasts were obtained from healthy young persons, healthy adults and sporadic AD patients. Properties of the induced neurons were examined by immunocytochemistry, qRT-PCR, western blotting, and electrophysiology. Results We established a protocol for efficient generation of hiBFCNs from adult human skin fibroblasts. They show electrophysiological properties of mature neurons and express BFCN-specific markers, such as CHAT, p75NTR, ISL1, and VACHT. As a proof-of-concept, our preliminary results further reveal that hiBFCNs from sporadic AD patients exhibit time-dependent TAU hyperphosphorylation in the soma and dysfunctional nucleocytoplasmic transport activities. Conclusions Aging-relevant BFCNs can be directly reprogrammed from human skin fibroblasts of healthy adults and sporadic AD patients. They show promises as an aging-relevant cell model for understanding AD pathology and may be employed for therapeutics identification for AD.

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