Establishment and preliminary characterization of a new myeloma cell line, C23/11

1989 ◽  
Vol 17 (6) ◽  
pp. 1055-1056 ◽  
Author(s):  
ENA PROSSER ◽  
KENNETH CARROLL ◽  
RICHARD O'KENNEDY ◽  
KIERAN CLARK ◽  
LIAM GROGAN ◽  
...  
1986 ◽  
Vol 163 (1) ◽  
pp. 117-126 ◽  
Author(s):  
Jan-Kan Chen ◽  
Tetsuji Okamoto ◽  
J.Denry Sato ◽  
Gordon H. Sato ◽  
Don B. McClure

2010 ◽  
Author(s):  
Sun-Young Kong ◽  
Weihua Song ◽  
Xian-Feng Li ◽  
Sabikun Nahar ◽  
Paola Dal Cin ◽  
...  

1986 ◽  
Vol 23 (2) ◽  
pp. 159-167 ◽  
Author(s):  
Ikeyama Shuichi ◽  
Nakagawa Shizue ◽  
Arakawa Mutsushi ◽  
Sugino Hiromu ◽  
Kakinuma Atsushi

1992 ◽  
Vol 41 (3) ◽  
pp. 218-224 ◽  
Author(s):  
Kazuyoshi Ishii ◽  
Kenji Yamato ◽  
Ichiro Kubonishi ◽  
Hirokuni Taguchi ◽  
Yuji Ohtsuki ◽  
...  

Blood ◽  
1988 ◽  
Vol 72 (4) ◽  
pp. 1163-1167
Author(s):  
TJ Ernst ◽  
A Gazdar ◽  
J Ritz ◽  
MA Shipp

Multiple myeloma is a disease characterized by a long, slowly progressive phase and a final, more aggressive one. Little is known about the mechanism of transformation of myeloma cells, although the clinical characteristics of the disease suggest a multi-step process. Recently, a myeloma cell line, NCI-H929, was isolated from a patient with aggressive preterminal disease and found to have a rearranged myc allele. This myeloma cell line has been further characterized in a focus formation assay to determine whether its unusual growth characteristics were associated with a second activated transforming gene. We now report that the NCI-H929 myeloma cell line has an activated rasn allele in addition to a rearranged myc allele. This is the first identification of an activated transforming gene in a multiple myeloma cell line; furthermore, the characterization of two independently activated oncogenes in this B cell malignancy has implications for both the pathogenesis and evolution of the disease.


Blood ◽  
1988 ◽  
Vol 72 (4) ◽  
pp. 1163-1167 ◽  
Author(s):  
TJ Ernst ◽  
A Gazdar ◽  
J Ritz ◽  
MA Shipp

Abstract Multiple myeloma is a disease characterized by a long, slowly progressive phase and a final, more aggressive one. Little is known about the mechanism of transformation of myeloma cells, although the clinical characteristics of the disease suggest a multi-step process. Recently, a myeloma cell line, NCI-H929, was isolated from a patient with aggressive preterminal disease and found to have a rearranged myc allele. This myeloma cell line has been further characterized in a focus formation assay to determine whether its unusual growth characteristics were associated with a second activated transforming gene. We now report that the NCI-H929 myeloma cell line has an activated rasn allele in addition to a rearranged myc allele. This is the first identification of an activated transforming gene in a multiple myeloma cell line; furthermore, the characterization of two independently activated oncogenes in this B cell malignancy has implications for both the pathogenesis and evolution of the disease.


2016 ◽  
Vol 58 (8) ◽  
pp. 1931-1940 ◽  
Author(s):  
Linda B. Baughn ◽  
Zohar Sachs ◽  
Klara E. Noble-Orcutt ◽  
Amit Mitra ◽  
Brian G. Van Ness ◽  
...  

Leukemia ◽  
1997 ◽  
Vol 11 (2) ◽  
pp. 284-293 ◽  
Author(s):  
I Van Riet ◽  
C De Greef ◽  
F Aharchi ◽  
C Woischwill ◽  
M De Waele ◽  
...  

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