Interactions between HEP G2 human hepatoma cells, platelets and endothelial cells

1989 ◽  
Vol 17 (3) ◽  
pp. 508-509 ◽  
Author(s):  
VERNON O. SKINNER ◽  
K. RICHARD BRUCKDORFER
2013 ◽  
Vol 641-642 ◽  
pp. 744-747
Author(s):  
Shu Jing Wang ◽  
Fei Wang ◽  
Jia Liu ◽  
Shan Jiang ◽  
Ning Chen ◽  
...  

The direct anti-tumor T-7 peptide of tumstatin was obtained to study its effect on human hepatoma cells (HepG-2) and human umbilical vein endothelial cells (ECV304). T-7 peptide was synthesized and its purity was up to 98.5%. MTT assay, growth curve, transmission electron microscopy(TEM) were used to detect the proliferation inhibition and pro-apoptotic function. MTT experiments and growth curve experiments showed that the survival of human hepatoma cells (HepG-2) decreased in a time- and dose-dependent way with the concentration of T-7 peptide increased. T-7 peptide can induce apoptosis of HepG-2 significantly. Apoptosis features were observed by TEM. However, the inhibition of T-7 peptide on human umbilical vein endothelial cells (ECV304) was weaker. Experiments showed thatT-7 peptide can affect HepG-2 cells. It had a certain therapeutic effect on human hepatocellular carcinoma. T-7 peptide have little effect on ECV304 cells, which means it didn’t influence the formation of tumor angiogenesis and normal cells


2003 ◽  
Vol 95 (2) ◽  
pp. 139-154 ◽  
Author(s):  
Hikmet Hakan Aydin ◽  
Handan Ak Celik ◽  
Remziye Deveci ◽  
Ender Terzioglu ◽  
Sabire Karacali ◽  
...  

2000 ◽  
Vol 150 (2) ◽  
pp. 255-264 ◽  
Author(s):  
Sharon Arrol ◽  
Michael I Mackness ◽  
Paul N Durrington

2007 ◽  
Vol 171 (1-2) ◽  
pp. 19-28 ◽  
Author(s):  
Xiao-Zhong Hu ◽  
Ying Xu ◽  
De-Cong Hu ◽  
Yang Hui ◽  
Fang-Xing Yang

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