[3H]1-[1-(2-Thienyl)-cyclohexyl]piperidine binding to the N-methyl-d-aspartic acid receptor complex

1988 ◽  
Vol 16 (3) ◽  
pp. 300-301
Author(s):  
JANET M. STIRLING ◽  
ALAN J. CROSS ◽  
A. RICHARD GREEN
Keyword(s):  
Aspartic Acid ◽  
Receptor Complex ◽  
Acid Receptor

scholarly journals Interaction of theN-Methyl-d-Aspartic Acid Receptor NR2D Subunit with the c-Abl Tyrosine Kinase

2000 ◽  
Vol 275 (17) ◽  
pp. 12725-12729 ◽  
Author(s):  
Robert T. Glover ◽  
Maria Angiolieri ◽  
Steven Kelly ◽  
Daniel T. Monaghan ◽  
Jean Y. J. Wang ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Aspartic Acid ◽  
Acid Receptor ◽  
Abl Tyrosine Kinase

scholarly journals Effect of Ginkgo Biloba Extract on N-Methyl-D-Aspartic Acid Receptor Subunit 2B Expression in a Salicylate-Induced Ototoxicity Model

2019 ◽  
Vol 12 (2) ◽  
pp. 169-175
Author(s):  
Sang-Yeon Lee ◽  
Sang Yoon Han ◽  
Ye-Ji Shim ◽  
Jae-Joon Han ◽  
DeukTae Cho ◽  
...  
Keyword(s):  
Aspartic Acid ◽  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract ◽  
Receptor Subunit ◽  
Acid Receptor

Simultaneous Fluorescence Imaging Reveals N-Methyl-d-aspartic Acid Receptor Dependent Zn2+/H+ Flux in the Brains of Mice with Depression

2020 ◽  
Vol 92 (5) ◽  
pp. 4101-4107 ◽  
Author(s):  
Xin Wang ◽  
Xiaoyi Bai ◽  
Di Su ◽  
Yandi Zhang ◽  
Ping Li ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Aspartic Acid ◽  
Acid Receptor

scholarly journals Antinociceptive Effect of Rat D-Serine Racemase Inhibitors, L-Serine-O-Sulfate, and L-Erythro-3-Hydroxyaspartate in an Arthritic Pain Model

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Claudio Laurido ◽  
Alejandro Hernández ◽  
Teresa Pelissier ◽  
Luis Constandil
Keyword(s):  
Chronic Pain ◽  
Aspartic Acid ◽  
Antinociceptive Effect ◽  
Serine Racemase ◽  
Pain Model ◽  
Acid Receptor ◽  
Culture Cells ◽  
Antinociceptive Effects ◽  
Nmdar Activation

N-methyl-D-aspartic acid receptor (NMDAr) activation requires the presence of D-serine, synthesized from L-serine by a pyridoxal 5′-phosphate-dependent serine racemase (SR). D-serine levels can be lowered by inhibiting the racemization of L-serine. L-serine-O-sulfate (LSOS) and L-erythro-3-hydroxyaspartate (LEHA), among others, have proven to be effective in reducing the D-serine levels in culture cells. It is tempting then to try these compounds in their effectiveness to decrease nociceptive levels in rat arthritic pain. We measured the C-reflex paradigm and wind-up potentiation in the presence of intrathecally injected LSOS (100 μg/10 μL) and LEHA (100 μg/10 μL) in normal and monoarthritic rats. Both compounds decreased the wind-up activity in normal and monoarthritic rats. Accordingly, all the antinociceptive effects were abolished when 300 μg/10 μL of D-serine were injected intrathecally. Since noin vivoresults have been presented so far, this constitutes the first evidence that SR inhibitions lower the D-serine levels, thus decreasing the NMDAr activity and the consequent development and maintenance of chronic pain.

Synthesis of (R)-4-Oxo-5-phosphononorvaline, anN-Methyl-D-aspartic Acid Receptor Selective β-Keto Phosphonate

Synthesis ◽  
1994 ◽  
Vol 1994 (08) ◽  
pp. 851-854 ◽  
Author(s):  
Duane E. Rudisill ◽  
Jeffrey P. Whitten
Keyword(s):  
Aspartic Acid ◽  
Acid Receptor

Modulation of noise-potentiated acoustic startle via the benzodiazepine-!g-aminobutyric acid receptor complex.

1991 ◽  
Vol 105 (5) ◽  
pp. 640-646 ◽  
Author(s):  
Carol K. Kellogg ◽  
A. T. Sullivan ◽  
Daniel Bitran ◽  
J. R. Ison
Keyword(s):  
Acoustic Startle ◽  
Aminobutyric Acid ◽  
Receptor Complex ◽  
Acid Receptor
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