Pig adipose tissue stearoyl-CoA desaturase activity: regulation and relationship to depot fatty acid composition

1986 ◽  
Vol 14 (3) ◽  
pp. 637-638 ◽  
Author(s):  
JENNIFER L. ROBERTS ◽  
FRANCES WHITTINGTON ◽  
MICHAEL ENSER
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Desaturase Activity ◽  
Activity Regulation ◽  
Stearoyl Coa Desaturase

Vitamin A regulation of stearoyl-CoA desaturase mRNA levels and fatty acid composition in sheep tissues

2004 ◽  
Vol 78 (2) ◽  
pp. 237-243 ◽  
Author(s):  
Z.C.T.R. Daniel ◽  
A.M. Salter ◽  
P.J. Buttery
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Oleic Acid ◽  
Retinoic Acid ◽  
Fatty Acid ◽  
Vitamin A ◽  
Acid Composition ◽  
Mrna Levels ◽  
Stearoyl Coa Desaturase

AbstractThe effect of vitamin A (retinol) on ovine stearoyl-CoA desaturase (SCD) mRNA levels and fatty acid composition was investigated. Sheep adipose tissue explants were maintained in culture for 24 h in the presence of all-trans retinoic acid (RA). Tissue SCD mRNA levels were increased with 25 μmol/l RA but the levels of SCD mRNA in tissue treated with 100 μmol/l RA were not different from control. The effect of vitamin A supplement on SCD mRNA levels in vivo was then characterized: growing lambs were given a concentrate diet (2 kg/day) containing 0, 0.225, 1.125 and 3.375 mg vitamin A per kg diet for 21 days. Treatment resulted in a concentration-dependent increase in adipose tissue and liver SCD mRNA levels, although the greatest effect was seen in the liver. SCD mRNA levels were highest in tissue from animals given 0.225 mg vitamin A per kg diet and further increases in vitamin A supplementation were not accompanied by corresponding increases in SCD gene expression. Fatty acid composition was also determined. Overall, tissue from animals given vitamin A had greater levels of both palmitoleic and oleic acid relative to their precursors. These data clearly show that SCD gene expression in adipose tissue and liver is regulated by retinoic acid and the liver appears to be most responsive. However, although significant, the change in the proportion of oleic acid was only small indicating that dietary manipulation with vitamin A is not a suitable method for increasing the unsaturated fat content of sheep meat.

Platelet Aggregation in Finnish Men and Its Relation to Fatty Acids in Platelets, Plasma and Adipose Tissue

1985 ◽  
Vol 54 (03) ◽  
pp. 563-569 ◽  
Author(s):  
M K Salo ◽  
E Vartiainen ◽  
P Puska ◽  
T Nikkari
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Platelet Aggregation ◽  
Acid Composition ◽  
Saturated Fatty Acids ◽  
Free Living ◽  
Ω3 Fatty Acids ◽  
Induced Aggregation

SummaryPlatelet aggregation and its relation to fatty acid composition of platelets, plasma and adipose tissue was determined in 196 randomly selected, free-living, 40-49-year-old men in two regions of Finland (east and southwest) with a nearly twofold difference in the IHD rate.There were no significant east-southwest differences in platelet aggregation induced with ADP, thrombin or epinephrine. ADP-induced platelet secondary aggregation showed significant negative associations with all C20-C22 ω3-fatty acids in platelets (r = -0.26 - -0.40) and with the platelet 20: 5ω3/20: 4ω 6 and ω3/ ω6 ratios, but significant positive correlations with the contents of 18:2 in adipose tissue (r = 0.20) and plasma triglycerides (TG) (r = 0.29). Epinephrine-induced aggregation correlated negatively with 20: 5ω 3 in plasma cholesteryl esters (CE) (r = -0.23) and TG (r = -0.29), and positively with the total percentage of saturated fatty acids in platelets (r = 0.33), but had no significant correlations with any of the ω6-fatty acids. Thrombin-induced aggregation correlated negatively with the ω3/6ω ratio in adipose tissue (r = -0.25) and the 20: 3ω6/20: 4ω 6 ratio in plasma CE (r = -0.27) and free fatty acids (FFA) (r = -0.23), and positively with adipose tissue 18:2 (r = 0.23) and 20:4ω6 (r = 0.22) in plasma phospholipids (PL).The percentages of prostanoid precursors in platelet lipids, i. e. 20: 3ω 6, 20: 4ω 6 and 20 :5ω 3, correlated best with the same fatty acids in plasma CE (r = 0.32 - 0.77) and PL (r = 0.28 - 0.74). Platelet 20: 5ω 3 had highly significant negative correlations with the percentage of 18:2 in adipose tissue and all plasma lipid fractions (r = -0.35 - -0.44).These results suggest that, among a free-living population, relatively small changes in the fatty acid composition of plasma and platelets may be reflected in significant differences in platelet aggregation, and that an increase in linoleate-rich vegetable fat in the diet may not affect platelet function favourably unless it is accompanied by an adequate supply of ω3 fatty acids.

Adipose tissue fatty acid composition and colon cancer: a case–control study

2013 ◽  
Vol 53 (4) ◽  
pp. 1029-1037 ◽  
Author(s):  
A. Giuliani ◽  
F. Ferrara ◽  
M. Scimò ◽  
F. Angelico ◽  
L. Olivieri ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Case Control Study ◽  
Case Control ◽  
Tissue Fatty Acid Composition ◽  
Adipose Tissue Fatty Acid ◽  
Control Study

Fatty Acid Composition of Subcutaneous Adipose Tissue in Mother-Infant Pairs

1987 ◽  
Vol 76 (1) ◽  
pp. 87-90 ◽  
Author(s):  
G. E. ANDERSEN ◽  
N. C. CHRISTENSEN ◽  
M. B. V. PETERSEN ◽  
K. B. JOHANSEN
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Subcutaneous Adipose Tissue ◽  
Subcutaneous Adipose
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