Effects of vasopressin and angiotensin II on fatty acid oxidation in isolated rat hepatocytes: increased 14CO2 production from [1-14C]oleate and [1-14C]butyrate

1983 ◽  
Vol 11 (2) ◽  
pp. 198-198 ◽  
Author(s):  
DAVID I. WATTS ◽  
MARY C. SUGDEN
Keyword(s):  
Fatty Acid ◽  
Angiotensin Ii ◽  
Fatty Acid Oxidation ◽  
Rat Hepatocytes ◽  
Acid Oxidation ◽  
Isolated Rat Hepatocytes ◽  
14Co2 Production ◽  
Isolated Rat

CYTOKINES INHIBIT FATTY ACID OXIDATION IN ISOLATED RAT HEPATOCYTES

Shock ◽  
1994 ◽  
Vol 1 (2) ◽  
pp. 123-129 ◽  
Author(s):  
V. Nachiappan ◽  
D. Curtiss ◽  
B. E. Corkey ◽  
L. Kilpatrick
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Rat Hepatocytes ◽  
Acid Oxidation ◽  
Isolated Rat Hepatocytes ◽  
Isolated Rat

scholarly journals Effect of starvation and diabetes on the sensitivity of carnitine palmitoyltransferase I to inhibition by 4-hydroxyphenylglyoxylate

1987 ◽  
Vol 243 (2) ◽  
pp. 405-412 ◽  
Author(s):  
T W Stephens ◽  
R A Harris
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Rat Hepatocytes ◽  
Isolated Hepatocytes ◽  
Carnitine Palmitoyltransferase ◽  
Time Dependent ◽  
Acid Oxidation ◽  
Moderate Increase ◽  
Dependent Manner ◽  
Carnitine Palmitoyltransferase I

The sensitivity of carnitine palmitoyltransferase I to inhibition by 4-hydroxyphenylglyoxylate was decreased markedly in liver mitochondria isolated from either 48 h-starved or streptozotocin-diabetic rats. These treatments of the rat also decreased the sensitivity of fatty acid oxidation by isolated hepatocytes to inhibition by this compound. Furthermore, incubation of hepatocytes prepared from fed rats with N6O2′-dibutyryl cyclic AMP also decreased the sensitivity, whereas incubation of hepatocytes prepared from starved rats with lactate plus pyruvate had the opposite effect on 4-hydroxyphenylglyoxylate inhibition of fatty acid oxidation. The sensitivity of carnitine palmitoyltransferase I of mitochondria to 4-hydroxyphenylglyoxylate increased in a time-dependent manner, as previously reported for malonyl-CoA. Likewise, oleoyl-CoA activated carnitine palmitoyltransferase I in a time-dependent manner and prevented the sensitization by 4-hydroxyphenylglyoxylate. Increased exogenous carnitine caused a moderate increase in fatty acid oxidation by hepatocytes under some conditions and a decreased 4-hydroxyphenylglyoxylate inhibition of fatty acid oxidation at low oleate concentration, without decreasing the difference in 4-hydroxyphenylglyoxylate inhibition between fed- and starved-rat hepatocytes. Time-dependent changes in the conformation of carnitine palmitoyltransferase I or the membrane environment may be involved in differences among nutritional states in 4-hydroxyphenylglyoxylate-sensitivity of carnitine palmitoyltransferase I.

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