Muscarinic receptor binding sites in the synaptosomal and microsomal fractions of bovine caudate nucleus

1981 ◽  
Vol 9 (5) ◽  
pp. 416-417 ◽  
Author(s):  
MARTYN R. GREGG ◽  
SHEILA SPANNER ◽  
G. BRIAN ANSELL
1985 ◽  
Vol 146 (5) ◽  
pp. 507-509 ◽  
Author(s):  
F. Owen ◽  
R. C. Bourne ◽  
M. Poulter ◽  
T. J. Crow ◽  
S. J. Paterson ◽  
...  

SummaryOpioid receptor binding sites were assessed in membrane preparations of caudate nucleus from post-mortem brains of controls and of patients with schizophrenia. There was no difference between the two groups in the total specific binding of 3H-etorphine or in its ‘μ’ and (‘δ+χ’) components. Similarly, the binding of 3H-naloxone did not differ between patients and controls. It is concluded that a previous report of reduced opioid receptors in caudate of schizophrenics is unlikely to prove a consistent finding and that the results of the present study offer no support to the claim that there is a general disturbance in opiate mechanisms in schizophrenia.


1998 ◽  
Vol 83 (5) ◽  
pp. 200-207 ◽  
Author(s):  
Jean L. Chelala ◽  
Ahmad Kilani ◽  
Martha J. Miller ◽  
Richard J. Martin ◽  
Paul Ernsberger

Receptors ◽  
1979 ◽  
pp. 73-80 ◽  
Author(s):  
N.J.M. Birdsall ◽  
A.S.V. Burgen ◽  
E.C. Hulme

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