Dietary manipulation of ornithine decarboxylase activity in mammary gland and liver of lactating rats

1981 ◽  
Vol 9 (5) ◽  
pp. 393-394
Author(s):  
MARGARET E. BROSNAN ◽  
DERMOT H. WILLIAMSON
Keyword(s):  
Mammary Gland ◽  
Ornithine Decarboxylase ◽  
Decarboxylase Activity ◽  
Dietary Manipulation ◽  
Ornithine Decarboxylase Activity

scholarly journals Effect of starvation and refeeding on polyamine concentrations and ornithine decarboxylase antizyme in mammary gland of lactating rats

1983 ◽  
Vol 212 (1) ◽  
pp. 149-153 ◽  
Author(s):  
M E Brosnan ◽  
R Farrell ◽  
H Wilansky ◽  
D H Williamson
Keyword(s):  
Mammary Gland ◽  
Nucleic Acid ◽  
Ornithine Decarboxylase ◽  
Acid Content ◽  
Marked Decrease ◽  
Mammary Glands ◽  
Nucleic Acid Content ◽  
Decarboxylase Activity ◽  
Ornithine Decarboxylase Activity ◽  
Polyamine Content

Starvation caused a marked increase in putrescine content in mammary gland of lactating rats, together with a marked decrease in activity of ornithine decarboxylase and appearance of measurable ornithine decarboxylase antizyme. 2. Refeeding for 5 h caused disappearance of free antizyme and ornithine decarboxylase activity returned to the value in fed animals. Putrescine concentration remained elevated. 3. There was no significant change in nucleic acid content of mammary gland from starved rats, but spermidine and spermine contents increased significantly. 4. Refeeding for 5 h returned the spermidine content of mammary glands to ‘fed’ values, and significantly decreased the content of spermine, although it did not reach control values. Thus changes in polyamine content of mammary gland in starved rats are clearly dissociated from changes in either RNA content or activities of polyamine-synthetic decarboxylases. 5. Starvation caused a fall in the content of spermidine in liver, with no change in spermine content. Refeeding for 5 h returned the spermidine content to ‘fed’ values.

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