Control of amino acid uptake by the lactating mammary gland of the rat

1981 ◽  
Vol 9 (5) ◽  
pp. 392-392 ◽  
Author(s):  
JUAN R. VIÑA ◽  
JUAN B. MONTORO ◽  
INMACULADA R. PUERTES ◽  
JOSE VIÑA
Keyword(s):  
Mammary Gland ◽  
Amino Acid ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Lactating Mammary Gland

Blood flow and net amino acid uptake by the lactating mammary gland: effect of starvation

1985 ◽  
Vol 13 (5) ◽  
pp. 876-877 ◽  
Author(s):  
JUAN R. VIÑA ◽  
ARGIMIRO RODRIGUEZ ◽  
JUAN B. MONTORO ◽  
ANTONIO IRADI ◽  
INMACULADA R. PUERTES ◽  
...  
Keyword(s):  
Blood Flow ◽  
Mammary Gland ◽  
Amino Acid ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Lactating Mammary Gland

Are the γ-glutamyl-amino acids signals for the amino acid uptake by lactating mammary gland?

1986 ◽  
Vol 14 (2) ◽  
pp. 311-312 ◽  
Author(s):  
JUAN R. VIÑA ◽  
INMACULADA R. PUERTES ◽  
JUAN B. MONTORO ◽  
ARGIMIRO RODRIGUEZ ◽  
JOSÉ VIÑA
Keyword(s):  
Amino Acids ◽  
Mammary Gland ◽  
Amino Acid ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Lactating Mammary Gland

scholarly journals Role of prolactin in amino acid uptake by the lactating mammary gland of the rat

FEBS Letters ◽  
1981 ◽  
Vol 126 (2) ◽  
pp. 250-252 ◽  
Author(s):  
José Viña ◽  
Inmaculada R. Puertes ◽  
Guillermo T. Saez ◽  
Juan R. Viña
Keyword(s):  
Mammary Gland ◽  
Amino Acid ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Lactating Mammary Gland

scholarly journals Effect of premature weaning on amino acid uptake by the mammary gland of lactating rats

1981 ◽  
Vol 200 (3) ◽  
pp. 705-708 ◽  
Author(s):  
J R Viña ◽  
I R Puertes ◽  
J Viña
Keyword(s):  
Amino Acids ◽  
Mammary Gland ◽  
Amino Acid ◽  
Amino Acid Uptake ◽  
Mammary Glands ◽  
Acid Uptake ◽  
Gamma Glutamyltransferase ◽  
Gamma Glutamyl ◽  
Lactating Mammary Gland

1. Arteriovenous differences of amino acids across the lactating mammary gland were measured in normal rats and weaned for 4, 5 and 24h. 2. Uptake of amino acids by mammary glands of rats weaned for 5h or more was significantly lower than that of controls. This was not reversed by injection of prolactin. 3. By using ‘unilaterally weaned’ rats we showed that milk accumulation plays an important role in amino acid uptake by mammary gland. 4. gamma-Glutamyltransferase activity was significantly lower in ‘weaned’ glands than in ‘normal’ glands. This provides further support for the hypothesis of the function of the gamma-glutamyl cycle in the mammary gland in vivo.

scholarly journals Involvement of γ-glutamyltransferase in amino-acid uptake by the lactating mammary gland of the rat

1981 ◽  
Vol 194 (1) ◽  
pp. 99-102 ◽  
Author(s):  
J Viña ◽  
I R Puertes ◽  
J M Estrela ◽  
J R Viña ◽  
J L Galbis
Keyword(s):  
Amino Acids ◽  
Mammary Gland ◽  
Amino Acid ◽  
Reduced Glutathione ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Gamma Glutamyltransferase ◽  
Lactating Mammary Gland ◽  
High Concentrations

1. Arteriovenous differences of amino acids across the lactating mammary gland have been measured in normal rats and in rats injected with serine–borate (an inhibitor of gamma-glutamyltransferase). 2. Comparison of the arteriovenous differences show that gamma-glutamyltransferase is involved in amino-acid uptake by the gland. 3. Reduced-glutathione content of isolated acini incubated with high concentrations of amino acids was lower than that of the controls. 4. High concentrations of amino acids had no effect on reduced-glutathione content of isolated acini when serine–borate was added to the incubation medium. 5. The findings provide evidence for the functioning of the gamma-glutamyl cycle in the lactating mammary gland in vivo.

Gamma-Glutamyl-Amino Acids as Signals for the Hormonal Regulation of Amino Acid Uptake by the Mammary Gland of the Lactating Rat

Neonatology ◽  
1985 ◽  
Vol 48 (4) ◽  
pp. 250-256 ◽  
Author(s):  
Juan R. Viña ◽  
Inmaculada R. Puertes ◽  
Juan B. Montoro ◽  
Guillermo T. Saez ◽  
José Viña
Keyword(s):  
Amino Acids ◽  
Mammary Gland ◽  
Amino Acid ◽  
Hormonal Regulation ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Gamma Glutamyl

Plasma amino acid uptake by the mammary gland of the lactating sow.

1997 ◽  
Vol 75 (5) ◽  
pp. 1266 ◽  
Author(s):  
N L Trottier ◽  
C F Shipley ◽  
R A Easter
Keyword(s):  
Mammary Gland ◽  
Amino Acid ◽  
Amino Acid Uptake ◽  
Plasma Amino Acid ◽  
Acid Uptake ◽  
Lactating Sow

scholarly journals Effects of hormones on protein and amino acid metabolism in mammary-gland explants of mice

1976 ◽  
Vol 158 (2) ◽  
pp. 355-359 ◽  
Author(s):  
L D Anderson ◽  
J A Rillema
Keyword(s):  
Mammary Gland ◽  
Amino Acid ◽  
Protein Biosynthesis ◽  
Insulin Response ◽  
Exposure Period ◽  
Amino Acid Uptake ◽  
Isobutyric Acid ◽  
Leucine Incorporation ◽  
Acid Uptake ◽  
Pregnant Mice

The effects of insulin, cortisol and prolactin on amino acid uptake and protein biosynthesis were determined in mammary-gland explants from mid-pregnant mice. Insulin stimulated [3H]leucine incorporation into protein within 15 min of adding insulin to the incubation medium. Insulin also had a rapid stimulatory effect on the rate of aminoiso[14C]butyric acid uptake, but it had no effect on the intracellular accumulation of [3H]leucine. Cortisol inhibited the rate of [3H]leucine incorporation into protein during the initial 4h of incubation, but it had no effect at subsequent times. [3H]Leucine uptake was unaffected by cortisol, but amino[14C]isobutyric acid uptake was inhibited after a 4h exposure period to this hormone. Prolactin stimulated the rate of [3H]leucine incorporation into protein when tissues were exposed to this hormone for 4h or more; up to 4h, however, no effect of prolactin was detected. At all times tested, prolactin had no effect on the uptake of either amino[14C]isobutyric acid or [3H]leucine. Incubation with actinomycin D abolished the prolactin stimulation of protein biosynthesis, but this antibiotic did not affect the insulin response. A distinct difference in the mechanism of action of these hormones on protein biosynthesis in the mammary gland is thus apparent.

Sign in / Sign up

Export Citation Format

Share Document