The Formation of Pyruvate from Citric Acid-Cycle Intermediates in Kidney Cortex

1979 ◽  
Vol 7 (4) ◽  
pp. 753-755 ◽  
Author(s):  
MALCOLM WATFORD ◽  
PATRICK VINAY ◽  
GUY LEMIEUX ◽  
ANDRÉ GOUGOUX
Keyword(s):  
Citric Acid ◽  
Citric Acid Cycle ◽  
Kidney Cortex ◽  
Acid Cycle

scholarly journals The regulation of glucose and pyruvate formation from glutamine and citric-acid-cycle intermediates in the kidney cortex of rats, dogs, rabbits and guinea pigs

1980 ◽  
Vol 188 (3) ◽  
pp. 741-748 ◽  
Author(s):  
M Watford ◽  
P Vinay ◽  
G Lemieux ◽  
A Gougoux
Keyword(s):  
Citric Acid ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Malic Enzyme ◽  
Citric Acid Cycle ◽  
Alternative Pathway ◽  
Lactate Production ◽  
Kidney Cortex ◽  
Acid Cycle ◽  
Pig Kidney

The suppression by 3-mercaptopicolinate of gluconeogenesis from glutamine or 2-oxoglutarate in rat or dog kidney tubules did not affect the amount of these substrates undergoing complete oxidation. Furthermore, 3-mercaptopicolinate caused an accumulation of lactate in dog tubules. 3-Mercaptopicolinate abolished both gluconeogenesis and substrate oxidation in tubules from rabbit and guinea-pig kidney. These results imply the presence of an alternative pathway to phosphoenolpyruvate carboxykinase/pyruvate kinase for the production of pyruvate from citric-acid-cycle intermediates in the kidney cortex of rats and dogs but not in that of rabbits or guinea pigs. Oxaloacetate decarboxylase (present in the kidney cortex of all four species) or ‘malic’ enzyme (present in rat and dog but absent in rabbit and guinea-pig kidney cortex) could function in this role. Our observations indicate that ‘malic’ enzyme is probably implicated in this phenomenon. The lactate production observed in dog tubules in the presence of 3-mercaptopicolinate can be suppressed when aspartate formation is inhibited by 2-amino-4-methoxy-trans-but-3-enoic acid. This suggests that the provision of cytosolic NADH from citric-acid-cycle intermediates is facilitated by accumulation of aspartate acting as a ‘sink’ for cytosolic oxaloacetate.

EFFECT OF SERUM GONADOTROPHIN ON DEHYDROGENASES OF THE CITRIC ACID CYCLE IN THE OVARY OF THE RAT

1963 ◽  
Vol 42 (4) ◽  
pp. 480-484 ◽  
Author(s):  
B. Eckstein ◽  
R. Landsberg
Keyword(s):  
Citric Acid ◽  
Citric Acid Cycle ◽  
Age Groups ◽  
Succinic Dehydrogenase ◽  
Immature Rat ◽  
Acid Cycle ◽  
Immature Rats ◽  
Rat Ovary

ABSTRACT The succinic, malic and isocitric dehydrogenases in the ovary of immature and mature, normal and serum gonadotrophin injected rats were examined. The Qo2 of these enzymes were markedly enhanced in the gonadotrophin injected rats of both age groups, except in the case of succinic dehydrogenase in the ovary of the immature rats, where a slight non-significant decrease was noted. It is concluded that in the mature rat ovary, gonadotrophin administration stimulates the activity of all the examined dehydrogenases of the citric acid cycle, whereas in the immature rat ovary, at least the isocitric- and malic dehydrogenases are thus stimulated.

scholarly journals CHROMATOGRAPHIC DETERMINATION OF THE ACIDS OF THE CITRIC ACID CYCLE IN TISSUES

1951 ◽  
Vol 193 (1) ◽  
pp. 277-283 ◽  
Author(s):  
CharlesE. Frohman ◽  
JamesM. Orten ◽  
ArthurH. Smith
Keyword(s):  
Citric Acid ◽  
Citric Acid Cycle ◽  
Chromatographic Determination ◽  
Acid Cycle

Clustering of sequential enzymes in the glycolytic pathway and the citric acid cycle

1990 ◽  
Vol 43 (4) ◽  
pp. 297-306 ◽  
Author(s):  
Sonia Beeckmans ◽  
Edilbert Van Driessche ◽  
Louis Kanarek
Keyword(s):  
Citric Acid ◽  
Citric Acid Cycle ◽  
Glycolytic Pathway ◽  
Acid Cycle
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