Insulin Regulates the Translation of Rat Skeletal-Muscle Messenger Ribonucleic Acid

1978 ◽  
Vol 6 (4) ◽  
pp. 751-751 ◽  
Author(s):  
LAILA H. FAHMY ◽  
DAVID P. LEADER
Keyword(s):  
Skeletal Muscle ◽  
Ribonucleic Acid ◽  
Rat Skeletal Muscle ◽  
Messenger Ribonucleic Acid

scholarly journals Overexpression of Staufen1 in DM1 mouse skeletal muscle exacerbates dystrophic and atrophic features

2020 ◽  
Vol 29 (13) ◽  
pp. 2185-2199
Author(s):  
Tara E Crawford Parks ◽  
Kristen A Marcellus ◽  
Christine Péladeau ◽  
Bernard J Jasmin ◽  
Aymeric Ravel-Chapuis
Keyword(s):  
Skeletal Muscle ◽  
Protein Kinase ◽  
Mouse Model ◽  
Ribonucleic Acid ◽  
Lower Sensitivity ◽  
Mouse Muscle ◽  
Messenger Ribonucleic Acid ◽  
Tensin Homolog ◽  
Mature Mouse ◽  
Dystrophia Myotonica Protein Kinase

Abstract In myotonic dystrophy type 1 (DM1), the CUG expansion (CUGexp) in the 3′ untranslated region of the dystrophia myotonica protein kinase messenger ribonucleic acid affects the homeostasis of ribonucleic acid-binding proteins, causing the multiple symptoms of DM1. We have previously reported that Staufen1 is increased in skeletal muscles from DM1 mice and patients and that sustained Staufen1 expression in mature mouse muscle causes a progressive myopathy. Here, we hypothesized that the elevated levels of Staufen1 contributes to the myopathic features of the disease. Interestingly, the classic DM1 mouse model human skeletal actin long repeat (HSALR) lacks overt atrophy while expressing CUGexp transcripts and elevated levels of endogenous Staufen1, suggesting a lower sensitivity to atrophic signaling in this model. We report that further overexpression of Staufen1 in the DM1 mouse model HSALR causes a myopathy via inhibition of protein kinase B signaling through an increase in phosphatase tensin homolog, leading to the expression of atrogenes. Interestingly, we also show that Staufen1 regulates the expression of muscleblind-like splicing regulator 1 and CUG-binding protein elav-like family member 1 in wild-type and DM1 skeletal muscle. Together, data obtained from these new DM1 mouse models provide evidence for the role of Staufen1 as an atrophy-associated gene that impacts progressive muscle wasting in DM1. Accordingly, our findings highlight the potential of Staufen1 as a therapeutic target and biomarker.

Sign in / Sign up

Export Citation Format

Share Document