Inhibition of Capping of Surface Immunoglobulins at Femtomolar Concentrations of Adriamycin, Compound ICRF-159 and Tetrodotoxin

1978 ◽  
Vol 6 (3) ◽  
pp. 659-661 ◽  
Author(s):  
MARIO GOSÁLVEZ ◽  
LUIS PEZZI ◽  
CARMEN VIVERO
Keyword(s):  
Surface Immunoglobulins

scholarly journals Surface Immunoglobulins of Circulating Lymphocytes in Mouse Plasmacytoma. II. The Influence of Plasmacytoma RNA on Surface Immunoglobulins of Lymphocytes

Blood ◽  
1972 ◽  
Vol 39 (4) ◽  
pp. 465-471 ◽  
Author(s):  
Nirmala Bhoopalam ◽  
Vincent Yakulis ◽  
Nicolas Costea ◽  
Paul Heller
Keyword(s):  
Immune System ◽  
Functional Impairment ◽  
Surface Structures ◽  
Normal Surface ◽  
Surface Receptors ◽  
Phenol Extraction ◽  
Surface Immunoglobulins ◽  
Circulating Lymphocytes

Abstract Circulating lymphocytes of plasmacytoma-carrying BALB/c mice were found to lose their normal surface immunoglobulins; in their place surface structures characteristic of the specific plasmacytoma globulin were demonstrated by the immunocytoadhesion technique. These changes were experimentally reproduced by the incubation of normal BALB/c lymphocytes with an RNA preparation obtained by hot phenol extraction from the excised plasmacytomas. RNA treated by RNAse was inactive, while DNAse or trypsin had no inactivating effect. Lymphocytes, killed with heat or KCN, underwent no alteration of surface receptors following incubation with the tumor RNA. Plasmacytoma RNA, injected intraperitoneally into normal mice, also altered the reactivity of circulating lymphocytes. These observations suggest the possibility that this effect contributes to the functional impairment of the immune system in this disease.

scholarly journals Acute lymphoblastic leukemia with pre-B-cell characteristics

Blood ◽  
1979 ◽  
Vol 54 (1) ◽  
pp. 269-273 ◽  
Author(s):  
JC Brouet ◽  
JL Preud'homme ◽  
C Penit ◽  
F Valensi ◽  
P Rouget ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cells ◽  
B Cell ◽  
Lymphoblastic Leukemia ◽  
Prognostic Significance ◽  
Light Chains ◽  
Surface Immunoglobulins ◽  
Blast Cells ◽  
B Cell Precursors

Abstract Blast cells from 6 of 50 patients with acute lymphoblastic leukemia (ALL) displayed intracytoplasmic mu chains in the absence of detectable light chains and surface immunoglobulins. These cells also expressed lalike and common ALL antigens. Terminal deoxynucleotidyltransferase was detectable in 2 of 5 cases tested. These blast cells are probably related to early B-cell precursors (pre-B cells). In 4 of 6 cases the disease had a tumoral presentation; the prognostic significance of this new subgroup, which accounts for 20% of patients with non-T non-B ALL, remains to be established.

scholarly journals Antigen-induced co-capping of IgM and IgD-like receptors on murine B cells.

1976 ◽  
Vol 144 (3) ◽  
pp. 852-857 ◽  
Author(s):  
J W Goding ◽  
J E Layton
Keyword(s):  
B Cells ◽  
Spleen Cells ◽  
Fluorescence Studies ◽  
Heavy Chains ◽  
Neonatal Mice ◽  
Specific Antisera ◽  
Surface Immunoglobulins ◽  
Old Mice

Double fluorescence studies indicated that most mature lymphocytes of 11-52-wk-old mice possess both IgM and IgD-like surface immunoglobulins, while spleen cells from neonatal mice possess surface IgM only. These molecules cap independently with class-specific antisera, but co-cap when capping is induced by antigen. It is proposed that the two heavy chains on individual lymphocytes possess similar or identical antigen-combining sites.

Increased Numbers of Lymphocytes with Single Class Surface Immunoglobulins in Reactive Hyperplasia of Lymphoid Tissue

1982 ◽  
Vol 78 (3) ◽  
pp. 316-323 ◽  
Author(s):  
Margarita Palutke ◽  
Bertram Schnitzer ◽  
Ila Mirchandani ◽  
Pamela M. Tabaczka ◽  
Roman Franklin ◽  
...  
Keyword(s):  
Lymphoid Tissue ◽  
Single Class ◽  
Surface Immunoglobulins ◽  
Reactive Hyperplasia
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