Effects of Carbon Tetrachloride on Isolated Rat Liver Cells: Stimulation of Lipid Peroxidation and Inhibitory Action of Free-Radical Scavengers

1978 ◽  
Vol 6 (3) ◽  
pp. 589-591 ◽  
Author(s):  
GIUSEPPE POLI ◽  
MARIA POLI CHIONO ◽  
TREVOR F. SLATER ◽  
MARIO U. DIANZANI ◽  
ENRICO GRAVELA
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Carbon Tetrachloride ◽  
Inhibitory Action ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Isolated Rat Liver ◽  
Rat Liver Cells ◽  
Isolated Rat ◽  
Stimulation Of

scholarly journals Effects of carbon tetrachloride on isolated rat hepatocytes. Inhibition of protein and lipoprotein secretion

1979 ◽  
Vol 178 (2) ◽  
pp. 509-512 ◽  
Author(s):  
E Gravela ◽  
E Albano ◽  
M U Dianzani ◽  
G Poli ◽  
T F Slater
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Carbon Tetrachloride ◽  
Inhibitory Action ◽  
Rat Hepatocytes ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Isolated Rat Hepatocytes ◽  
Lipoprotein Secretion ◽  
Isolated Rat

The effects of carbon tetrachloride on protein and lipoprotein secretion, and on lipid peroxidation, have been investigated in isolated rat hepatocytes. It was found that although the free-radical scavenger promethazine completely suppressed the increased peroxidation produced by carbon tetrachloride, it had no effect on the inhibitory action of carbon tetrachloride on lipoprotein secretion. In consequence, the latter effect of carbon tetrachloride does not appear to be mediated through a peroxidative stage.

scholarly journals The stimulatory effects of carbon tetrachloride on peroxidative reactions in rat liver fractions in vitro. Inhibitory effects of free-radical scavengers and other agents

1971 ◽  
Vol 123 (5) ◽  
pp. 823-828 ◽  
Author(s):  
T. F. Slater ◽  
B. C. Sawyer
Keyword(s):  
Free Radical ◽  
Vitamin E ◽  
Carbon Tetrachloride ◽  
Rat Liver ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Inhibitory Effects ◽  
Low Concentrations ◽  
Stimulation Of

1. The effects of a number of free-radical scavengers and other agents on the stimulation of malonaldehyde production due to low concentrations of carbon tetrachloride have been studied in rat liver microsome suspensions. 2. Promethazine, propyl gallate and NN′-diphenyl-p-phenylenediamine were extremely active in inhibiting the stimulation of malonaldehyde production due to carbon tetrachloride; inhibitory effects were demonstrable with these agents at 0.1μm. 3. Low concentrations (1–100nm) of vitamin E–polyethylene glycol 1000–succinate increased the stimulation of malonaldehyde production due to carbon tetrachloride, but higher concentrations of the vitamin E preparation decreased both the stimulation due to carbon tetrachloride and the endogenous peroxidation that occurs in the absence of carbon tetrachloride. 4. Other agents tested that were effective in the range 1–20μm in decreasing the stimulation of malonaldehyde production due to carbon tetrachloride were inosine, desferrioxamine and EDTA. Agents tested that were not effective, except at very high concentrations (100μm or greater), were Nupercaine, Cetab and sodium phenobarbitone. 5. The results are discussed in terms of the mechanisms responsible for the observed inhibitions of malonaldehyde production, and of the relevance of the in vitro system to the liver damage produced by carbon tetrachloride in vivo.

Changes in lipid peroxidation and free radical scavengers in the brain of hyper- and hypothyroid aged rats

1995 ◽  
Vol 147 (2) ◽  
pp. 361-365 ◽  
Author(s):  
T Mano ◽  
R Sinohara ◽  
Y Sawai ◽  
N Oda ◽  
Y Nishida ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Lipid Peroxide ◽  
Lipid Peroxides ◽  
Thiobarbituric Acid ◽  
Free Radical Scavengers ◽  
Aged Rats ◽  
Radical Scavengers ◽  
Old Rats ◽  
The Brain

Abstract To determine how lipid peroxides and free radical scavengers are changed in the brain of hyper- or hypothyroid rats, we examined the behavior of lipid peroxide and free radical scavengers in the cerebral cortex of aged (1·5 years old) rats that had been made hyper- or hypothyroid by the administration of thyroxine or methimazol for 4 weeks. Concentrations of catalase, Mn-superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) were increased in hyperthyroid rats compared with euthyroid rats. Concentrations of total SOD, Cu,Zn-SOD and GSH-PX were increased but that of Mn-SOD was decreased in hypothyroid animals. There were no differences among hyperthyroid, hypothyroid and euthyroid rats in the levels of coenzymes 9 or 10. The concentration of lipid peroxides, determined indirectly by the measurement of thiobarbituric acid reactants, was decreased in hyperthyroid rats but not in hypothyroid rats when compared with euthyroid animals. These findings suggest that free radicals and lipid peroxides are scavenged to compensate for the changes induced by hyper- or hypothyroidism. Journal of Endocrinology (1995) 147, 361–365

FREE RADICAL SCAVENGING ACTIVITY OF ACACIA NILOTICA PODS

INDIAN DRUGS ◽  
2014 ◽  
Vol 51 (07) ◽  
pp. 14-22
Author(s):  
T. A Khan ◽  
◽  
A. Gohel
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Radical Scavenging Activity ◽  
Folk Medicine ◽  
Radical Scavenging ◽  
Acacia Nilotica ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Radical Production ◽  
Medicinal Value

Biomolecules can be oxidized by free radicals. This oxidative damage has an important etiological role in aging and the development of diseases like cancer, atherosclerosis, and other inflammatory disorders. Synthetic antioxidants, such as butylated hydroxyl anisole, are good free radical scavengers; however, they can be carcinogenic. Therefore, there is an increasing interest in searching for antioxidants of natural origin. Acacia nilotica has a versatile medicinal value as folk medicine. The present study aims at screening the methanol and aqueous extracts of the pods of Acacia nilotica for antioxidant activity. The effect of these extracts on inhibition of 1, 1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide radicals and of lipid peroxidation was studied. The results indicated that both the extracts exhibited a significant reduction in the DPPH and NO radical production along with a significant reduction in lipid peroxidation. The results indicate the pods of Acacia nilotica to be a cheap and easily available source of antioxidants

scholarly journals The Effects of Hyperthyroidism on Lipid Peroxidation, Erythrocyte Glutathione and Glutathione Peroxidase

2011 ◽  
Vol 30 (1) ◽  
pp. 11-14 ◽  
Author(s):  
Abdellah Ali ◽  
Phalisteen Sultan
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Glutathione Peroxidase ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Hyperthyroid Patients

The Effects of Hyperthyroidism on Lipid Peroxidation, Erythrocyte Glutathione and Glutathione PeroxidaseThe aim of this study was to determine if lipid peroxidation, glutathione, and glutathione peroxidase levels can be effected by hyperthyroidism. Twenty-three subjects with hyperthyroidism (18 females/5 males), and 19 euthyroid subjects (11 females/8 males) were examined in this study. Plasma and erythrocytes malondialdehyde (MDA), erythrocytes glutathione (GSH) and glutathione peroxidase (GSH-PX) were measured. Results show that an increase in lipid peroxidation was observed in the hyperthyroid patients (p < 0.001). This was accompanied by a decrease in glutathione and glutathione peroxidase in the same subjects (p < 0.001). The results suggest that hyperthyroidism has some effects on lipid peroxidation and free radical scavengers.

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