The Effect of Some Foreign Compounds on Hepatic Xenobiotic Metabolism and on the Urinary Excretion of d-Glucuronic Acid Metabolites in the Rat

1977 ◽  
Vol 5 (1) ◽  
pp. 308-309 ◽  
Author(s):  
BRIAN G. LAKE ◽  
RONALD C. LONGLAND ◽  
ROSALYN A. HODGSON ◽  
BRIAN J. SEVERN ◽  
SHARAT D. GANGOLLI
Keyword(s):  
Urinary Excretion ◽  
Glucuronic Acid ◽  
Xenobiotic Metabolism ◽  
Acid Metabolites

The Effect of some Inducers of Hepatic Xenobiotic-Metabolizing Enzymes on the Urinary Excretion of d-Glucuronic Acid Metabolites in the Rat

1975 ◽  
Vol 3 (1) ◽  
pp. 188-191
Author(s):  
BRIAN G. LAKE ◽  
RONALD C. LONGLAND ◽  
ROSALYN A. HODGSON ◽  
BRIAN J. SEVERN ◽  
SHARAT D. GANGOLLI ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Glucuronic Acid ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes ◽  
Acid Metabolites

The effect of prolonged sodium phenobarbitone treatment on hepatic xenobiotic metabolism and the urinary excretion of metabolites of the d-glucuronic acid pathway in the rat

1978 ◽  
Vol 27 (19) ◽  
pp. 2357-2361 ◽  
Author(s):  
Brian G. Lake ◽  
Ronald C. Longland ◽  
Rosalyn A. Harris ◽  
Brian J. Severn ◽  
Sharat D. Gangolli
Keyword(s):  
Urinary Excretion ◽  
Glucuronic Acid ◽  
Xenobiotic Metabolism ◽  
Acid Pathway

The Effect of 4-Hydroxybiphenyl and 2-Naphthol on Hepatic Xenobiotic Metabolism and the Urinary Excretion of Metabolites of the d-Glucuronic Acid Pathway in the Rat

1978 ◽  
Vol 6 (6) ◽  
pp. 1246-1248 ◽  
Author(s):  
BRIAN G. LAKE ◽  
RONALD C. LONGLAND ◽  
IRENE A. HEROD ◽  
MICHAEL A. COLLINS ◽  
SHARAT D. GANGOLLI
Keyword(s):  
Urinary Excretion ◽  
Glucuronic Acid ◽  
Xenobiotic Metabolism ◽  
Acid Pathway

Comparative Study of Glucose and Fructose Metabolism in Infants with Reference to Utilization and to the Accumulation of Glycolytic Intermediates

PEDIATRICS ◽  
1958 ◽  
Vol 22 (4) ◽  
pp. 773-773
Keyword(s):  
Urinary Excretion ◽  
Urine Excretion ◽  
Acid Base ◽  
Rapid Infusion ◽  
Acid Base Equilibrium ◽  
Glycolytic Intermediates ◽  
Acid Metabolites ◽  
Lactate And Pyruvate ◽  
Maintenance Requirements ◽  
Sodium And Potassium

Recently considerable interest has been directed at the comparative rates of utilization of glucose and fructose, administered intravenously. The present study was designed to carry out such a comparison using intakes of the carbohydrates which would provide sufficient calories to meet the maintenance requirements. The observations included a comparison of the extent of accumulation of certain acid metabolites and disturbances of the acid-base equilibrium which result from the rapid infusion of glucose and fructose. It was found that infusions of glucose and fructose in solution with electrolytes at 1 gm/kg/hr enabled both sugars to be utilized completely, without significant differences in the excretion of water, sodium and potassium. When the sugars were infused at a rate of 2 gm/kg/hr, 20% of the glucose and 9.9% of the fructose were excreted in the urine. Excretion of sodium in the urine with infusions of glucose led to loss of 79% of the intake, while for fructose the urinary excretion was 127% of intake, although no significant differences in excretion of water and potassium were noted. Infusions of fructose were accompanied by much greater increases of lactate and pyruvate in the blood than were caused by infusions of glucose. The urinary excretion of lactic acid was also greater with fructose than with glucose. It is stated that the superior utilization of fructose at rapid rates of infusion is not entirely advantageous because of the accompanying acidosis, which is of sufficient severity to make limitation of the rate of its infusion advisable.

URINARY EXCRETION OF FREE AND CONJUGATED GLUCURONIC ACID IN JAUNDICED NEWBORN

1971 ◽  
Vol 60 (4) ◽  
pp. 437-440 ◽  
Author(s):  
A. GOTLIEB ◽  
I. NIR ◽  
J. PESACH
Keyword(s):  
Urinary Excretion ◽  
Glucuronic Acid
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