Fatty Acid Elongation by Preparations from Pisum sativum

1977 ◽  
Vol 5 (1) ◽  
pp. 287-289 ◽  
Author(s):  
JOHN L. HARWOOD ◽  
PAUL BOLTON
Keyword(s):  
Fatty Acid ◽  
Pisum Sativum ◽  
Fatty Acid Elongation

MYB96 stimulates C18 fatty acid elongation in Arabidopsis seeds

2015 ◽  
Vol 9 (3) ◽  
pp. 161-166 ◽  
Author(s):  
Hong Gil Lee ◽  
Bo-Yeon Park ◽  
Hyun Uk Kim ◽  
Pil Joon Seo
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Elongation

scholarly journals Circadian Control of Fatty Acid Elongation by SIRT1 Protein-mediated Deacetylation of Acetyl-coenzyme A Synthetase 1

2014 ◽  
Vol 289 (9) ◽  
pp. 6091-6097 ◽  
Author(s):  
Saurabh Sahar ◽  
Satoru Masubuchi ◽  
Kristin Eckel-Mahan ◽  
Simone Vollmer ◽  
Luisa Galla ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Coenzyme A ◽  
Fatty Acid Elongation ◽  
Acetyl Coenzyme A ◽  
Acetyl Coenzyme ◽  
Circadian Control

Naphthalic anhydride prevents inhibition of fatty acid elongation by thiocarbamates

1998 ◽  
Vol 49 (7) ◽  
pp. 1897-1903 ◽  
Author(s):  
Philippa B Barrett ◽  
John L Harwood
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Elongation ◽  
Naphthalic Anhydride

scholarly journals Plasmalogen Deficiency and Overactive Fatty Acid Elongation Biomarkers in Serum of Breast Cancer Patients Pre- and Post-Surgery—New Insights on Diagnosis, Risk Assessment, and Disease Mechanisms

Cancers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 4170
Author(s):  
Satomi Tomida ◽  
Dayan B. Goodenowe ◽  
Teruhide Koyama ◽  
Etsuko Ozaki ◽  
Nagato Kuriyama ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acid ◽  
Surgical Removal ◽  
Fatty Acid Elongation ◽  
Breast Cancer Patients ◽  
Case Control Studies ◽  
Post Surgery ◽  
Lipid Species ◽  
Ethanolamine Plasmalogen ◽  
Accurate Mass Spectrometry

The polyunsaturated fatty acid (PUFA) elongase, ELOVL5, is upregulated in breast cancer (BC) vs. adjacent normal tissue. We performed a comprehensive lipid metabolomic analysis of serum using high-resolution accurate mass spectrometry from two case-control studies that included non-BC, BC subjects pre-surgery, and BC subjects one-month post-surgery to determine if the metabolic signatures of over-active fatty acid elongation and other lipid changes could be detected in BC vs. non-BC subjects: study 1 (n = 48: non-BC, n = 69: pre-surgery BC); study 2 (blinded validation: n = 121: non-BC, n = 62: pre-surgery BC, n = 31: one month post-surgery). The ratio of the ELOVL5 precursor, linoleic acid (18:2) to a non-ELOVL5 precursor, oleic acid (18:1) was evaluated in multiple lipid pools (phosphatidylethanolamine (PtdEtn), phosphatidylcholine (PtdCho), lyso-PtdCho, and free fatty acids). This ratio was lower in pre-surgery BC subjects in all pools in both studies (p < 0.001). At one-month post-surgery, the 18:2/18:1 ratios increased vs. pre-surgery and were no longer different from non-BC subjects (p > 0.05 expect for lyso-PtdCho). In contrast to the elongation biomarkers, docosahexaenoic acid (22:6n-3) containing ethanolamine plasmalogen (EtnPls) species were observed to be further decreased in BC subjects one-month post-surgery vs. pre-surgery levels (p < 0.001). These results are consistent with the hypothesis that ELOVL5 is upregulated in BC tissue, which would result in the selective depletion of 18:2 vs. 18:1 containing lipid species. Surgical removal of the tumor removes the overactive ELOVL5 effect on serum lipids. In contrast, the low EtnPls levels do not appear to be caused by BC tumor activity and may be pre-existent and a possible risk factor for BC. These results indicate that it may be possible to screen for both breast cancer risk and breast cancer activity using a simple blood test.

scholarly journals Investigation of Fatty Acid Elongation and Desaturation Steps inFusarium lateritiumby Quantitative Two-dimensional Deuterium NMR Spectroscopy in Chiral Oriented Media

2009 ◽  
Vol 284 (16) ◽  
pp. 10783-10792 ◽  
Author(s):  
Vincent Baillif ◽  
Richard J. Robins ◽  
Steven Le Feunteun ◽  
Philippe Lesot ◽  
Isabelle Billault
Keyword(s):  
Fatty Acid ◽  
Nmr Spectroscopy ◽  
Deuterium Nmr ◽  
Fatty Acid Elongation ◽  
Two Dimensional
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