Stabilization of the Free-Radical Product of Phenazine Methosulphate in Bile and Formation of the Free-Radical Product in vitro by Reaction with Bilirubin

1973 ◽  
Vol 1 (4) ◽  
pp. 926-928 ◽  
Author(s):  
KENNETH A. K. LOTT ◽  
T. F. SLATER
Keyword(s):  
Free Radical ◽  
Radical Product ◽  
Phenazine Methosulphate ◽  
Free Radical Product

The alkoxy radical, RCH2Ȯ, as a free radical product in x-irradiated single crystals of nucleosides and nucleotides

1977 ◽  
Vol 67 (3) ◽  
pp. 1211 ◽  
Author(s):  
William A. Bernhard ◽  
David M. Close ◽  
Jürgen Hüttermann ◽  
Herbert Zehner
Keyword(s):  
Free Radical ◽  
Single Crystals ◽  
Alkoxy Radical ◽  
Radical Product ◽  
Free Radical Product

Metabolic Activation of Carbon Tetrachloride to a Free-Radical Product: Studies using a Spin Trap

1978 ◽  
Vol 6 (5) ◽  
pp. 962-964 ◽  
Author(s):  
A. INGALL ◽  
K. A. K. LOTT ◽  
T. F. SLATER ◽  
S. FINCH ◽  
A. STIER
Keyword(s):  
Free Radical ◽  
Carbon Tetrachloride ◽  
Spin Trap ◽  
Metabolic Activation ◽  
Radical Product ◽  
Free Radical Product

Radical reactions of nitric oxide synthases

2004 ◽  
Vol 71 ◽  
pp. 39-49 ◽  
Author(s):  
Dennis J. Stuehr ◽  
Chin-Chuan Wei ◽  
Jerome Santolini ◽  
Zhi- Qiang Wang ◽  
Mika Aoyagi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Electron Transfer ◽  
Free Radical ◽  
Structural Features ◽  
Nitric Oxide Synthases ◽  
Radical Reactions ◽  
Radical Product ◽  
O2 Activation ◽  
Health And Disease ◽  
Free Radical Product

NOSs (nitric oxide synthases) are flavohaem enzymes that function broadly in human health and disease. We are combining mutagenesis, crystallographic and rapid kinetic methods to understand their mechanism and regulation. The NOSs create a transient tetrahydrobiopterin radical within the enzyme to generate their free radical product (NO). Recent work is revealing how critically important this process is at all levels of catalysis. This article will synthesize four seemingly disparate but related aspects of NOS tetrahydrobiopterin radical formation: (i) how it enables productive O2 activation by providing an electron to the enzyme haem, (ii) what structural features help to regulate this electron transfer, (iii) how it enables NOS to synthesize NO from its diamagnetic substrate and (iv) how it allows NOS to release NO after each catalytic cycle instead of other nitorgen oxide-containing products.

FREE RADICAL PRODUCT FORMED BY THE REACTION OF DEHYDROASCORBIC ACID WITH AMINO ACIDS

1974 ◽  
Vol 3 (2) ◽  
pp. 125-128 ◽  
Author(s):  
Mitsuo Namiki ◽  
Midori Yano ◽  
Tateki Hayashi
Keyword(s):  
Amino Acids ◽  
Free Radical ◽  
Dehydroascorbic Acid ◽  
Radical Product ◽  
Free Radical Product

1120: Citrate and Vitamin E Blunt the SWL-Induced Free Radical Surge in an In-Vitro MDCK Cell Culture Model

2004 ◽  
Vol 171 (4S) ◽  
pp. 295-295
Author(s):  
Fernando C. Delvecchio ◽  
Ricardo M. Brizuela ◽  
Karen J. Byer ◽  
W. Patrick Springhart ◽  
Saeed R. Khan ◽  
...  
Keyword(s):  
Cell Culture ◽  
Free Radical ◽  
Vitamin E ◽  
Mdck Cell ◽  
Cell Culture Model ◽  
Culture Model

Acetylcholinesterase Inhibitory Potential and Antioxidant Activities of Five Cultivars of Rosa Damascena Mill. From Isparta, Turkey

2020 ◽  
Vol 18 (4) ◽  
pp. 354-359
Author(s):  
Shirin Tarbiat ◽  
Azize Simay Türütoğlu ◽  
Merve Ekingen
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Free Radical ◽  
Neurodegenerative Disorder ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Acetylcholinesterase Activity ◽  
Rosa Damascena ◽  
Free Radical Damage

Alzheimer's disease is a neurodegenerative disorder characterized by memory loss and impairment of language. Alzheimer's disease is strongly associated with oxidative stress and impairment in the cholinergic pathway, which results in decreased levels of acetylcholine in certain areas of the brain. Hence, inhibition of acetylcholinesterase activity has been recognized as an acceptable treatment against Alzheimer's disease. Nature provides an array of bioactive compounds, which may protect against free radical damage and inhibit acetylcholinesterase activity. This study compares the in vitro antioxidant and anticholinesterase activities of hydroalcoholic extracts of five cultivars of Rosa Damascena Mill. petals (R. damascena 'Bulgarica', R. damascena 'Faik', R. damascena 'Iranica', R. damascena 'Complex-635' and R. damascena 'Complex-637') from Isparta, Turkey. The antioxidant activities of the hydroalcoholic extracts were tested for ferric ion reduction and DPPH radical scavenging activities. The anti-acetylcholinesterase activity was also evaluated. All rose cultivars showed a high potency for scavenging free radical and inhibiting acetylcholinesterase activity. There was a significant correlation between antioxidant and acetylcholinesterase inhibitory activity. Among cultivars, Complex-635 showed the highest inhibitory effect with an IC50 value of 3.92 µg/mL. Our results suggest that all these extracts may have the potential to treat Alzheimer's disease with Complex-635 showing more promise.

Protective Activity of Fucoidan and Alginic Acid against Free Radical-Induced Oxidative Stress under in Vitro and Cellular System

2007 ◽  
Vol 12 (4) ◽  
pp. 191-196 ◽  
Author(s):  
Mi-Jung So ◽  
Boh-Kyung Kim ◽  
Mi-Jin Choi ◽  
Kun-Young Park ◽  
Sook-Hee Rhee ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Alginic Acid ◽  
Cellular System ◽  
Protective Activity

scholarly journals Microwave-Assisted Synthesis, Characterization, Antimicrobial and Antioxidant Activity of Some New Isatin Derivatives

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
G. Kiran ◽  
T. Maneshwar ◽  
Y. Rajeshwar ◽  
M. Sarangapani
Keyword(s):  
Antioxidant Activity ◽  
Free Radical ◽  
Radical Scavenging ◽  
Microwave Assisted Synthesis ◽  
Stable Free Radical ◽  
Ft Ir ◽  
Antimicrobial And Antioxidant Activity ◽  
New Compounds ◽  
Isatin Derivatives

A series of β-Isatin aldehyde-N,N′-thiocarbohydrazone derivatives were synthesized and assayed for theirin vitroantimicrobial and antioxidant activity. The new compounds were characterized based on spectral (FT-IR, NMR, MS) analyses. All the test compounds possessed a broad spectrum of activity having MIC values rangeing from 12.5 to 400 μg/ml against the tested microorganisms. Among the compounds3e,3jand3nshow highest significant antimicrobial activity. The free radical scavenging effects of the test compounds against stable free radical DPPH (α,α-diphenyl-β-picryl hydrazyl) and H2O2were measured spectrophotometrically. Compounds3j,3n,3l, and3e, respectively, had the most effective antioxidant activity against DPPH and H2O2scavenging activity.

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