An Alternative Pathway for the Enzymic Degradation of [35S]Heparin by Flavobacterium heparinum

1973 ◽  
Vol 1 (1) ◽  
pp. 271-274 ◽  
Author(s):  
GRAHAM EMBERY ◽  
JOSEPHINE M. DAY
Keyword(s):  
Alternative Pathway ◽  
Flavobacterium Heparinum

Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease

2002 ◽  
Vol 38 ◽  
pp. 37-49 ◽  
Author(s):  
Janelle Nunan ◽  
David H Small
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Alternative Pathway ◽  
Protein A ◽  
Proteolytic Processing ◽  
Gamma Secretase ◽  
Amyloid Beta Protein ◽  
Protein Precursor ◽  
Amyloid Beta Protein Precursor

The proteolytic processing of the amyloid-beta protein precursor plays a key role in the development of Alzheimer's disease. Cleavage of the amyloid-beta protein precursor may occur via two pathways, both of which involve the action of proteases called secretases. One pathway, involving beta- and gamma-secretase, liberates amyloid-beta protein, a protein associated with the neurodegeneration seen in Alzheimer's disease. The alternative pathway, involving alpha-secretase, precludes amyloid-beta protein formation. In this review, we describe the progress that has been made in identifying the secretases and their potential as therapeutic targets in the treatment or prevention of Alzheimer's disease.

Respiratory Rates and Alternative Pathway Capacity during Early Germination of Soybean

Crop Science ◽  
1989 ◽  
Vol 29 (4) ◽  
pp. 976-980 ◽  
Author(s):  
R. M. Ismail ◽  
R. E. Mullen ◽  
C. R. Stewart ◽  
A. D. Knapp
Keyword(s):  
Alternative Pathway ◽  
Early Germination
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