Inositol trisphosphate and calcium oscillations

2007 ◽  
Vol 74 (1) ◽  
pp. 1 ◽  
Author(s):  
Michael J. Berridge
Keyword(s):  
Inositol Trisphosphate ◽  
Calcium Oscillations

Cytosolic Calcium Oscillations in Smooth Muscle Cells

Physiology ◽  
2000 ◽  
Vol 15 (1) ◽  
pp. 50-55 ◽  
Author(s):  
Jean-Pierre Savineau ◽  
Roger Marthan
Keyword(s):  
Smooth Muscle ◽  
Membrane Potential ◽  
Cell Membrane ◽  
Smooth Muscle Cells ◽  
Inositol Trisphosphate ◽  
Muscle Cells ◽  
Cytosolic Calcium ◽  
Calcium Oscillations ◽  
Membrane Receptors ◽  
Cell Membrane Potential

In a variety of smooth muscle cells, agonists activating membrane receptors induce oscillations in the cytoplasmic Ca2+ concentration via an inositol trisphosphate-activated mechanism. Ca2+ oscillations participate in the control of cell membrane potential and the tone of smooth muscle. There is evidence that alterations in Ca2+ oscillations modulate smooth muscle responsiveness.

scholarly journals A method for determining the dependence of calcium oscillations on inositol trisphosphate oscillations

2006 ◽  
Vol 103 (6) ◽  
pp. 1675-1680 ◽  
Author(s):  
J. Sneyd ◽  
K. Tsaneva-Atanasova ◽  
V. Reznikov ◽  
Y. Bai ◽  
M. J. Sanderson ◽  
...  
Keyword(s):  
Inositol Trisphosphate ◽  
Calcium Oscillations

scholarly journals Inositol Trisphosphate-Induced Calcium Release in the Generation of Calcium Oscillations in Bovine Eggs

1995 ◽  
Vol 53 (4) ◽  
pp. 766-774 ◽  
Author(s):  
Rafael A. Fissore ◽  
Clara Pinto-Correia ◽  
James M. Robl
Keyword(s):  
Calcium Release ◽  
Inositol Trisphosphate ◽  
Calcium Oscillations

scholarly journals On the dynamical structure of calcium oscillations

2017 ◽  
Vol 114 (7) ◽  
pp. 1456-1461 ◽  
Author(s):  
James Sneyd ◽  
Jung Min Han ◽  
Liwei Wang ◽  
Jun Chen ◽  
Xueshan Yang ◽  
...  
Keyword(s):  
Inositol Trisphosphate ◽  
Dynamical Behavior ◽  
Cell Types ◽  
Oscillation Period ◽  
Calcium Oscillations ◽  
Canonical Model ◽  
Dynamical Structure ◽  
Order Of Magnitude ◽  
Slow Variables ◽  
Speed Of Evolution

Oscillations in the concentration of free cytosolic Ca2+ are an important and ubiquitous control mechanism in many cell types. It is thus correspondingly important to understand the mechanisms that underlie the control of these oscillations and how their period is determined. We show that Class I Ca2+ oscillations (i.e., oscillations that can occur at a constant concentration of inositol trisphosphate) have a common dynamical structure, irrespective of the oscillation period. This commonality allows the construction of a simple canonical model that incorporates this underlying dynamical behavior. Predictions from the model are tested, and confirmed, in three different cell types, with oscillation periods ranging over an order of magnitude. The model also predicts that Ca2+ oscillation period can be controlled by modulation of the rate of activation by Ca2+ of the inositol trisphosphate receptor. Preliminary experimental evidence consistent with this hypothesis is presented. Our canonical model has a structure similar to, but not identical to, the classic FitzHugh–Nagumo model. The characterization of variables by speed of evolution, as either fast or slow variables, changes over the course of a typical oscillation, leading to a model without globally defined fast and slow variables.

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