scholarly journals Protective effect of dexmedetomidine on kidney injury of parturients with preeclampsia undergoing cesarean section: a randomized controlled study

2019 ◽  
Vol 39 (5) ◽  
Author(s):  
Qing-lin Zhang ◽  
Lei Wang ◽  
Ming-jun Xu ◽  
Tian-long Wang
Keyword(s):  
Blood Pressure ◽  
Cesarean Section ◽  
Intervention Group ◽  
Kidney Injury ◽  
Visual Analogue Score ◽  
Inflammatory Factors ◽  
Controlled Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Protective Effects

AbstractThe present study aimed to elucidate the effects of dexmedetomidine on kidney injury of parturients with preeclampsia (PE) undergoing cesarean section. Total 134 cesarean delivery women with PE were randomly divided into intervention group (IG) and control group (CG). Both groups underwent combined spinal and epidural anesthesia (CSEA), the IG was treated with 0.4 μg/(kg·min) dexmedetomidine for 10 min before surgery. The CG was treated with equivalent saline. Heart rate (HR), blood pressure, oxygen saturation (SpO2) of the two groups were measured at different time point after administration. Level of inflammatory factors were detected by enzyme-linked immunosorbent assay (ELISA). Visual analogue score (VAS), Ramsay sedation score (RSS), and kidney injury related indexes were evaluated at different time points. The plasma-drug concentration of patients was determined by High Performance Liquid Chromatography (HPLC) method. Compared with CG, HR, PE, and diastolic blood pressure (DBP) showed lower level while SpO2 showed higher level in IG. Furthermore, expression of tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), and IL-10 in IG was decreased after drug administration, the contents of β2-MG, KIM-1 and urine protein were also decreased in contrast to the CG (all P<0.05). Besides, VAS score was decreased but Ramsay score was increased in the IG (both P<0.05). The results of HPLC showed that the half life of dexmedetomidine was about 20 min and it is speculated that the drug can be quickly metabolized within 24 h. Dexmedetomidine exerted protective effects on kidney injury of parturients with PE undergoing cesarean section.

scholarly journals Effects of Music Intervention during Cesarean Section on the Level of the Mother’s Anxiety: A Randomized Controlled Study

2021 ◽  
Author(s):  
Jule Eriç Horasanlı ◽  
NUR DEMIRBAS
Keyword(s):  
Blood Pressure ◽  
Cesarean Section ◽  
Randomized Study ◽  
Intervention Group ◽  
Anxiety Score ◽  
Controlled Study ◽  
Control Group ◽  
Music Intervention ◽  
Significant Difference ◽  
Anxiety Levels

Background: Anxiety is commonly experienced during the delivery process and has been shown to have adverse effects on maternal and infant health outcomes. Music interventions tend to mitigate the effects of anxiety in a variety of populations, are low-cost and easily accessible, and have high acceptability. The aim of this study is to evaluate the effectiveness of music intervention on expectant mothers’ vital signs and anxiety levels during cesarean section. Methods: This study is a single-center, controlled, randomized study. The women in the intervention group listened to music via earpieces during the operation. The control group received standard treatment without music. Cesarean section was performed under regional anesthesia. The State-Trait Anxiety Inventory (STAI) was administered to the patients before and after the operation. Results: There was no significant difference between the pre- and postoperative systolic blood pressure, diastolic blood pressure, heart rate, respiratory rate, or O2 saturation parameters of the music group and the control group (p>0.05). The pre-operative STAI anxiety score was similar in the music (45.58±4.60) and control (43.82±4.33) groups (p=0.183). After the operation, the anxiety score of the music group (35.88±5.39) was found to be statistically significantly lower than the anxiety score of the control group (42.14±3.75) (p<0.001). Conclusion: This study supports the hypothesis that slow, rhythmic Sufi music during cesarean section can reduce patients’ anxiety. It is possible to distract the patient from negative thoughts and reduce stress. The results show that patients who listened to music during surgery had significantly lower anxiety levels than patients who did not listen to music.

scholarly journals Protective Effects and Mechanisms of Rosuvastatin on Acute Kidney Injury Induced by Contrast Media in Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Zehui Jiang ◽  
Jun Zhang ◽  
Yuanan Lu
Keyword(s):  
Protective Effect ◽  
Contrast Medium ◽  
Renal Injury ◽  
Intervention Group ◽  
Inflammatory Factors ◽  
Control Group ◽  
Renal Tubules ◽  
Protective Effects ◽  
Sod Activity ◽  
Biochemical Indicators

Objective. To explore the protective effect and mechanism of rosuvastatin on acute renal injury induced by a nonionic hypotonic contrast medium in rats. Methods. Forty-eight healthy adult SD rats were randomly divided into three groups: normal control group (NC); contrast medium control group (CM); and rosuvastatin intervention group (RI). The RI group was intragastrically administered with a 10 mg/kg of rosuvastatin 12 h prior to the contrast exposure. All rats in CM and RI groups were inoculated with 10 mL/kg of chemical (IV) while the same volume of saline for the NC group. At 24 h and 72 h posttreatments, pathomorphological changes of renal tubules were documented, respectively, and several biochemical indicators were tested to assess renal injury of experimental rats. Results. Compared with the CM group, rats in the RI group showed significantly reduced injury of kidneys and decreased levels of biochemical indicators such as blood Scr, blood Cys-C, urine NAG, urine α1-MG, and urine mALB. The serum Hs-CRP in the CM group increased significantly from 24 h to 72 h (p<0.05), but this was not observed in the rats of the RI group. In addition, SOD activity in the RI group was significantly increased (p<0.01) while SOD activity in renal tissue decreased significantly with time in the CM group (p<0.05). Conclusion. Short-term intervention with rosuvastatin can lead to reduced kidney damage associated with the contrast agent by reducing the levels of inflammatory factors and oxidative stress. Thus, rosuvastatin intervention has a protective effect on rats from contrast-induced nephropathy.

Anti-inflammatory and antioxidant effect of ginger in tuberculosis

2016 ◽  
Vol 13 (2) ◽  
Author(s):  
Rashmi Anant Kulkarni ◽  
Ajit Ramesh Deshpande
Keyword(s):  
Intervention Group ◽  
Radical Scavenging ◽  
Antioxidant Effect ◽  
Controlled Study ◽  
Tnf Alpha ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Pulmonary Tb ◽  
Antitubercular Treatment ◽  
Anti Inflammatory

Abstract: Tuberculosis (TB) has reemerged to become the world’s leading cause of death from a single infectious agent. Inflammatory cytokines play an important role during the course of the disease and may be responsible for tissue damage by lipid peroxidation. The study was aimed to explore the anti-inflammatory and antioxidant effect of ginger in pulmonary TB patients.: A total of 69 pulmonary TB patients participated in a randomized and placebo-controlled study. The intervention group received 3 g of ginger extract daily for 1 month and placebo group was supplemented with starch capsule. Participants of both groups were taking standard antitubercular treatment during the study. The concentrations of tumor necrosis factor (TNF) alpha, ferritin and malondialdehyde (MDA) in blood samples were analyzed before and after the intervention by using enzyme-linked immunosorbent assay for TNF alpha and ferritin and spectrophotometry for MDA.: Ginger supplementation significantly reduced the levels of TNF alpha, ferritin and MDA in ginger supplemented group in comparison to baseline. Ginger supplementation with antitubercular treatment significantly lowered TNF alpha, ferritin and MDA concentrations in comparison to control group.: Ginger was found to be effective as an anti-inflammatory and antioxidant supplement along with anti-TB therapy as it possesses strong free radical scavenging property.

scholarly journals Clinical Effects of Integrated Traditional Chinese and Western Medicine in Treating Severe Preeclampsia and Its Influence on Maternal and Infant Outcomes after Cesarean Section under Combined Lumbar and Epidural Anesthesia

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Xiaolu Wang ◽  
Wenpeng Wei ◽  
Yanyan Qi ◽  
Lihua Dong ◽  
Yun Zhang
Keyword(s):  
Blood Pressure ◽  
Cesarean Section ◽  
Epidural Anesthesia ◽  
Western Medicine ◽  
Inflammatory Factors ◽  
Control Group ◽  
Clinical Effects ◽  
Infant Outcomes ◽  
Maternal And Infant Outcomes ◽  
Experimental Group

Objective. This study is aimed to observe the clinical effects of integrated traditional Chinese and Western medicine in treating severe preeclampsia (SPE) and its effects on maternal and infant outcomes after cesarean section under combined lumbar and epidural anesthesia. Method. One hundred and sixty-six pregnant women with SPE were randomly divided into an experimental group and control group, with 83 cases in each group. The control group was given conventional treatments such as magnesium sulfate, and the experimental group received self-made traditional Chinese medicine decoction for oral administration. Results. The total clinical effective rate of treatment in the experimental group was significantly higher than that in the control group. After treatment, the systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and 24 h proteinuria (24 h PRO) levels of the experimental group were significantly lower than those of the control group. After cesarean section (c-section) under combined lumbar and epidural anesthesia, there were statistically significant differences in placental abruption, uterine weakness, fetal intrauterine distress, and neonatal asphyxia in the experimental group, while there were no significant differences in oligohydramnios. After treatment, the contents of inflammatory factors in both groups decreased, and the decrease was more prominent in the experimental group. After treatment, the levels of blood urea nitrogen (BUN), serum creatinine (Scr), and albumin (Alb) and β2 microglobulin (β2-MG) of the two groups of patients decreased, and the levels of them in the experimental group decreased. After treatment, the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the two groups increased. However, the levels of malondialdehyde (MDA), lipid peroxide (LPO), and advanced oxidation protein products (AOPP) all reduced, and the increase or decrease in the experimental group was more prominent. Conclusion. The combination of traditional Chinese and Western medicine can reduce the blood pressure of a patient with SPE. After the combined spinal-epidural anesthesia and cesarean section, it can significantly improve the maternal and infant outcomes and renal function, reduce inflammatory factors levels and body oxidative stress, and increase the activities of antioxidant enzymes.

Differential effects of Bach's Orchestral Suite No. 3 on blood pressure and heart rate - a prospective controlled study

2018 ◽  
Vol 10 (1) ◽  
pp. 7
Author(s):  
Hans-Joachim Trappe ◽  
Irini Maria Breker
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Clinical Trials ◽  
Intervention Group ◽  
Controlled Study ◽  
Control Group ◽  
Sound Exposure ◽  
Group Methods ◽  
Prospective Controlled Study ◽  
Different Parts

Background There is little known whether music of different styles can directly alter blood pressure (BP) and heart rate (HR) in humans. We studied the potential effects of Bach’s orchestral Suite No. 3 in comparison to silence (S [“controls CO]) on BP and HR.Objective To analyse the effect of different music styles (intervention group) on BP, HR and C compared to S (control group).Methods 120 volunteers aged 25-75 years were randomly assigned in the intervention group (n=60) or to a control group (n=60). Interventional music styles were the different parts of Bach’s Suite No. 3, BWV 1068 [Ouverture, Air, Gavotte, Bourrée, Gigue]). Sixty healthy volunteers served as “control group” (CO): they underwent an identical study protocol but without music application.Results In studied volunteers, systolic, diastolic BP (mm Hg) and HR (min-1) decreased when Bach was played compared to CO (p<0.001). Prior to the study BPsyst was 128.3+11.3 mm Hg, BPdiast was 81.9+7.9 Hg and HR was 75.3+12.0 bpm. After sound exposure or in CO the following results were observed (table). *p<0.001, ap=0.01, bp=0.08                        BPsyst (mm Hg)                  BPdiast (mm Hg)                 HR (min-1)Ouverture        120.9+12.4*               76.9+8.8*                   69.8+11.2*Air                  121.1+12.4*               77.1+7.9*                   68.4+9.4*Gavotte           120.9+12.6*               77.0+8.9*                   68.5+9.8*Bourrée           120.6+13.7*               76.5+9.4*                   66.4+8.4*Gigue              120.4+15.2*               78.5+11.1*                 68.1+9.2*Controls          120.6+8.7a                  75.4+5.5b                    78.8+11.9*Conclusions The results provide clear evidence for the potential of Bach’ music styles to influence cardiovascular parameters. All parts of the Suite No. 3 lead to decreased values of BP and HR. In the control group we could not observe similar findings.Trial registration German Clinical Trials Register (DRKS00009835)Funding: None 

scholarly journals N-Acetylcysteine Attenuates Cisplatin-Induced Acute Kidney Injury by Inhibiting the C5a Receptor

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Shuai Huang ◽  
Jian You ◽  
Kun Wang ◽  
Yueqiang Li ◽  
Ying Zhang ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Antioxidant Properties ◽  
Kidney Injury ◽  
Nutritional Supplement ◽  
Treated Group ◽  
Inflammatory Factors ◽  
Control Group ◽  
Protective Effects ◽  
C5a Receptor ◽  
C5ar Expression

N-acetylcysteine has been widely used as a nutritional supplement and drug in humans for its antioxidant properties. The complement activation fragment C5a is a strong proinflammatory molecule that mediates cell adhesion, chemotaxis, and the complex biological functions. However, the effect of NAC on the C5a, and the relationship of those two with cisplatin-induced acute kidney injury are unknown. In cisplatin induced AKI mouse model, mice with NAC administration had a marked improvement in renal function (BUN and Cr), decreased pathological damage, reduced inflammation, and alleviated renal oxidative stress. Furthermore, C5a and C5aR expression in the cisplatin-treated group was notably increased compared with the control group, and this increase could be significantly inhibited by NAC. In addition, neutrophils coexpressed distinctly with C5aR, and the number of infiltrating neutrophils (MPO+ly6G+) and inflammatory factors decreased with NAC treatment in the cisplatin-treated group. Overall, these data demonstrate that NAC could ameliorate cisplatin-induced nephrotoxicity in mice and the protective effects may be conducted by inhibiting the activation of kidney inflammation and the complement system.

Investigation of the Effect of Operating Room Environment and Cesarean Section Orientation on Physiological Parameters (BP, heart rate, respiration) in Mothers of Candidate for Cesarean Section in Shiraz, a Clinical Trial Study

2021 ◽  
Vol 17 ◽  
Author(s):  
Jamshid Eslami ◽  
Neda Hatami ◽  
Aazadeh Amiri ◽  
Marzieh Akbarzadeh
Keyword(s):  
Blood Pressure ◽  
Clinical Trial ◽  
Heart Rate ◽  
Cesarean Section ◽  
Pregnant Women ◽  
Operating Room ◽  
Intervention Group ◽  
Physiological Parameters ◽  
Control Group ◽  
The Mean

Background: : Changes in physiological parameters in pregnant women are important factors in mothers who are candidates for cesarean section. Objective:: The aim of present study was to investigate the effect of operating room and cesarean section orientation on the physiological parameters (BP, heart rate, respiration) of pregnant women undergoing cesarean section. Materials and Methods:: This clinical trial study was performed on 80 pregnant women referring to cesarean section in hospitals affiliated to Shiraz University of Medical Sciences in 2019. The samples were randomly divided into two control (n = 40) and intervention groups (n = 40). The intervention group participated in 4 sessions of training classes. The control group used routine hospital trainings. The parameters were measured before and after the intervention in two groups. Data were analyzed using SPSS software (version 21), independent t-test and analysis of covariance. Results: The mean of post-training blood pressure in the intervention group 82.78(7.86) and in the control group 84.08 (7.44) was not statistically significant (p < .487). After intervention, the mean of heart rate in the intervention group 82.15 (8.10) and in the control group 83.43 (8.54) was statistically significant (p <0.0001). After intervention, the mean of respiratory rate in the intervention group was 94.28 (0.96) and in the control group was 75.96 (1.08) (P <0.0001). Conclusions: Although the patient's operating room and cesarean section orientation did not affect mothers' mean blood pressure; it reduced the mean of their heart rate and respiratory rate. It is important for medical staff to play an important role in identifying important strategies in managing the anxiety of pregnant women in order to improve their physiological indicators.

A Randomized Controlled Study of the Effectiveness of Electrophysiological Monitoring of Dexmedetomidine in Patients with Brain Damage of Various Origins

2020 ◽  
Vol 75 (5) ◽  
pp. 490-499
Author(s):  
Yuri Y. Kiryachkov ◽  
Marina V. Petrova ◽  
Bagautdin G. Muslimov ◽  
Sergey A. Bosenko ◽  
Mikhail M. Gorlachev
Keyword(s):  
Intervention Group ◽  
Clinical Effectiveness ◽  
Protective Role ◽  
Digital Data ◽  
Controlled Study ◽  
Control Group ◽  
Average Dose ◽  
Autonomic Nervous System Dysfunction ◽  
Sympathetic Hyperactivity ◽  
Starting Dose

Background.At the same time, the main effect of the use of this drug is the elimination of the autonomic nervous system dysfunction and sympatholysis. It seems important to search for a method of indications and selection of a dose of dexmedetomidine in intensive care.Aims to improve the clinical effectiveness of the electrophysiological navigation of the prolonged use of dexmedetomidine in patients with brain pathology of various origins.Methods.The study included 83 patients 2050 days after the traumatic brain injury, anoxic damage; consequences of acute disorders of cerebral. 37 patients comprised the 1st intervention group with a clinical course of dexmedetomidine (male 28; female 9; average age 49.62.3 years) and 46 patients comprised the 2nd control group without pharmacological correction with dexmedetomidine (male 23; female 23, average age 512.5 years). Criteria for the inclusion of prolonged infusion of the drug dexmedetomidine (Orion Pharma, Finland) are based on heart rate variability (HRV) indicators characteristic of sympathetic hyperactivity, the target task of titration of doses of dexmedetomidine served as the parameters for achieving normal HRV indicators, the appearance of parasympathetic hyperactivity served as the basis for reducing the dosage of the drug or stopping it of application. HRV parameters were recorded before dexmetomedine infusion-initially, on 13; 45; 910; 1520 days of drug administration.Results.The starting dose of dexmedetomidine with sympathetic hyperactivity in patients was 0.12 to 0.24 g.kg1.hr1(average dose 0.160.01; total 200 mg/day). According to digital data from HRV, the effective dose of dexmedetomidine ED50 was 0.260.03 g.kg1.hr1(total daily 353.835.1 g) and was achieved on day 910 using dexmedetomidine.Conclusions.The protective role of dexmedetomidine with correction of sympathetic hyperactivity based on electrophysiological navigation according to the HRV is reliable in the following indicators: The improvement of consciousness; a significant decrease in the incidence of distress lung syndrome; septic shock; mortality.

Effect of Dietary Education on Cardiovascular risk Factors in Rheumatoid Arthritis Patients

2020 ◽  
Vol 16 ◽  
Author(s):  
Rahil Taheri ◽  
Shahram Molavynejad ◽  
Parvin Abedi ◽  
Elham Rajaei ◽  
Mohammad Hosein Haghighizadeh
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Statistical Tests ◽  
Intervention Group ◽  
Serum Levels ◽  
Control Group ◽  
Dietary Education

Aim: The aim of this study was to investigate the effect of dietary education on cardiovascular risk factors in patients with rheumatoid arthritis. Method: In this randomized clinical trial, 112 patients with rheumatoid arthritis were randomly assigned into two groups, intervention and control. Dietary education was provided for the intervention group in 4 sessions; anthropometric measurements, serum levels of RF, triglycerides, cholesterol, HDL, LDL, and fasting blood sugar were measured before and three months after intervention. Data was analyzed using SPSS software and appropriate statistical tests. Results: The mean of total cholesterol (p <0.001), triglycerides (p = 0.004), LDL (p <0.001), systolic blood pressure (p = 0.001), diastolic blood pressure (p = 0.003), FBS and BMI (p <0.001) were decreased significantly in the intervention group after education compared the control group. Conclusion: Traditional care for rheumatoid arthritis patients is not enough. Patients need more education in order to improve their situation.

Effectiveness of Medication Review Services on Diabetes Self-Care in Primary Care Patients (Preprint)

2020 ◽  
Author(s):  
Tay Siew Cheng Sarah ◽  
Lim Jit Fan Christina ◽  
Tan Soo Chieng Daphne ◽  
Tan Seok Yee Maureen ◽  
Chen Jieying Cordelia ◽  
...  
Keyword(s):  
Physical Activity ◽  
Primary Healthcare ◽  
Medication Review ◽  
Intervention Group ◽  
Self Care ◽  
Effective Intervention ◽  
Controlled Study ◽  
Control Group ◽  
Dietary Control ◽  
Glucose Management

BACKGROUND Diabetes is one of the most common medical conditions referred to medication review service run by pharmacists, OBJECTIVE This study aims to determine whether pharmacist-run MRS can be an effective intervention tool to improve patients’ participation in self-care of diabetes. METHODS This randomised controlled study was conducted in five public primary healthcare centres from December 2014 to October 2016. Participants were 40 to 80 years of age and had been diagnosed with type 2 diabetes. These participants were prescribed with five or more chronic medications, of which at least one was an antidiabetic medication, by the primary healthcare centres’ doctors. The participants were randomly recruited into the intervention or control arm. A self-developed questionnaire which incorporated the validated Diabetes Self-Management Questionnaire (DSMQ) was administered face-to-face by the study team to the participants prior to and after MRS. MRS was not administered to participants in the control group. RESULTS A total of 221 participants completed the follow up. There were 105 participants in the control arm and 116 in the intervention arm. The DSMQ Sum Scale score of the control group improved by 0.16 ± 1.11 (p= 0.136) while the intervention group improved by 0.40 ± 0.99 (p=0.000). Participants in the intervention group reported a better improvement in their self-care of diabetes, specifically in glucose management (0.38± 1.35, p=0.003), dietary control (0.26±1.66, p=0.096) and physical activity (0.67±2.36, p=0.003). CONCLUSIONS Pharmacist-run MRS is an effective intervention tool to improve participants’ self-care of diabetes, particularly in glucose management, dietary control and physical activity.

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