scholarly journals Non-coding RNA in drug resistance of hepatocellular carcinoma

2018 ◽  
Vol 38 (5) ◽  
Author(s):  
Bisha Ding ◽  
Weiyang Lou ◽  
Liang Xu ◽  
Weimin Fan
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Resistance ◽  
Clinical Application ◽  
Circular Rna ◽  
Potential Clinical Application ◽  
Cancer Occurrence ◽  
Non Coding Rna ◽  
The Future ◽  
Non Coding Rnas

Hepatocellular carcinoma (HCC) has been one of the most highly lethal cancers. The acquisition of drug resistance accounts for the majority of poor effects of chemotherapy in HCC. Non-coding RNAs (ncRNAs) including miRNAs, long ncRNAs (lncRNAs), and circular RNA (circRNA) have been well-documented to participate in cancer occurrence and progression. Recently, multiple studies have highlighted the key roles of ncRNAs in chemoresistance of HCC. In addition, accumulating evidence has demonstrated that they can serve as biomarkers in diagnosis, treatment, and prognosis of HCC. In this review, we first overviewed up-to-date findings regarding miRNA and lncRNA in drug resistance of HCC, then summarized specific mechanisms that they modulate chemoresistance of HCC, and finally discussed their potential clinical application in overcoming the obstacle of HCC chemoresistance in the future.

scholarly journals The Latest Overview of circRNA in the Progression, Diagnosis, Prognosis, Treatment, and Drug Resistance of Hepatocellular Carcinoma

2021 ◽  
Vol 10 ◽  
Author(s):  
Dandan Xiong ◽  
Rongquan He ◽  
Yiwu Dang ◽  
Huayu Wu ◽  
Zhenbo Feng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Resistance ◽  
Early Stage ◽  
Circular Rna ◽  
Biological Behavior ◽  
Prognostic Indicators ◽  
Treatment Result ◽  
Diagnosis And Prognosis ◽  
Non Coding Rna ◽  
Long Time

Hepatocellular carcinoma (HCC) is one of the main causes of tumor-related deaths worldwide. Due to the lack of obvious early symptoms and the lack of sensitive screening indicators in the early stage of HCC, the vast majority of patients are diagnosed with advanced or metastatic HCC, resulting in dissatisfactory treatment result. Therefore, it is urgent to determine effective and sensitive diagnostic and prognostic indicators and to determine new therapeutic targets. Circular RNA (circRNA) is a type of non-coding RNA that has been neglected for a long time. In recent years, it has been proved to play an important role in the development of many human diseases. Increasing evidence shows that change in circRNA expression has an extensive effect on the biological behavior of HCC. In this study, we comprehensively tracked the latest progress of circRNA in the pathogenesis of HCC, and reviewed its role as a biomarker for diagnosis and prognosis prediction in patients with HCC. In addition, we also summarized the potential of circRNA as therapeutic target in HCC and its relationship with HCC drug resistance, providing clues for the clinical development of circRNA-based therapeutic strategies.

Whole Transcriptome Analysis: Implication to Estrous Cycle Regulation

2021 ◽  
Author(s):  
Xiaopeng An ◽  
Yue Zhang ◽  
Fu Li ◽  
Zhanhang Wang ◽  
Shaohua Yang ◽  
...  
Keyword(s):  
Estrous Cycle ◽  
Transcriptome Analysis ◽  
Circular Rna ◽  
Differentially Expressed ◽  
Non Coding Rna ◽  
Non Coding Rnas ◽  
Whole Transcriptome Analysis ◽  
Cycle Regulation ◽  
Whole Transcriptome ◽  
Goat Ovary

Abstract BackgroundEstrous cycle is one of female characteristics after sexual maturity, including estrus (ES) and diestrus (DS) stages. Estrous cycle is important in female physiology and its disorder may lead to diseases. In the latest years, effects of non-coding RNAs and mRNA on estrous cycle start to arouse much concern, however, a whole transcriptome analysis among non-coding RNAs and mRNA has not been reported.ResultsHere we report a whole transcriptome analysis of goat ovary in estrus and diestrus periods. Estrus synchronization was conducted to induce the estrus phase and on day 32, the goats naturally shifted into diestrus stage. The ovary RNA of estrus and diestrus stages was respectively collected to perform RNA-sequencing. Then the circular RNA; microRNA; long non-coding RNA; mRNA databases of goat ovary were acquired, and the differentially expressions between estrus and diestrus stages were screened to construct circRNA-miRNA-mRNA/lncRNA and lncRNA-miRNA/mRNA networks, thus providing potential pathways that involved in the regulation of estrous cycle. Differentially expressed mRNAs, such as MMP9, TIMP1, 3BHSD and PTGIS, and differentially expressed microRNAs, such as miR-21-3p，miR-202-3p and miR-223-3p, which play key roles in estrous cycle regulation were extracted from the network.ConclusionsOur data provided the miRNA, circRNA, lncRNA and mRNA databases of goat ovary and each differentially expressed profile between ES and DS. Networks among differentially expressed miRNAs, circRNAs, lncRNAs and mRNAs were constructed to provide valuable resources for the study of estrous cycle and related diseases.

scholarly journals The emerging role of microRNAs and long noncoding RNAs in drug resistance of hepatocellular carcinoma

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Ling Wei ◽  
Xingwu Wang ◽  
Liyan Lv ◽  
Jibing Liu ◽  
Huaixin Xing ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Resistance ◽  
Human Cancer ◽  
Noncoding Rnas ◽  
Circular Rna ◽  
Long Noncoding Rnas ◽  
Protein Coding ◽  
Multiple Tumor ◽  
Nucleolar Rnas

Abstract Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and the second most lethal human cancer. A portion of patients with advanced HCC can significantly benefit from treatments with sorafenib, adriamycin, 5-fluorouracil and platinum drugs. However, most HCC patients eventually develop drug resistance, resulting in a poor prognosis. The mechanisms involved in HCC drug resistance are complex and inconclusive. Human transcripts without protein-coding potential are known as noncoding RNAs (ncRNAs), including microRNAs (miRNAs), small nucleolar RNAs (snoRNAs), long noncoding RNAs (lncRNAs) and circular RNA (circRNA). Accumulated evidences demonstrate that several deregulated miRNAs and lncRNAs are important regulators in the development of HCC drug resistance which elucidates their potential clinical implications. In this review, we summarized the detailed mechanisms by which miRNAs and lncRNAs affect HCC drug resistance. Multiple tumor-specific miRNAs and lncRNAs may serve as novel therapeutic targets and prognostic biomarkers for HCC.

scholarly journals Long Non-Coding RNA Linc-USP16 Functions As a Tumour Suppressor in Hepatocellular Carcinoma by Regulating PTEN Expression

2017 ◽  
Vol 44 (3) ◽  
pp. 1188-1198 ◽  
Author(s):  
Jidong Sui ◽  
Xuejun Yang ◽  
Wenjing Qi ◽  
Kun Guo ◽  
Zhenming Gao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Lines ◽  
Tumour Suppressor ◽  
Pten Expression ◽  
The Novel ◽  
Aberrant Expression ◽  
Non Coding Rna ◽  
Non Coding Rnas ◽  
And Migration ◽  
Long Non Coding Rna

Background/Aims: Recent evidence has indicated the crucial regulatory roles of long non-coding RNAs (lncRNAs) in tumour biology. In hepatocellular carcinoma (HCC), aberrant expression of lncRNAs plays an essential role in HCC tumourigenesis. However, the potential roles and regulatory mechanisms of the novel human lncRNA, Linc-USP16, in HCC are unclear. Methods: To investigate the function of Linc-USP16 in HCC, we first analysed the expression levels of Linc-USP16 in HCC patient tissues and cell lines via q-RT-PCR and established overexpressed or knockdown HCC cell lines. Results: Here, we found that Linc-USP16 expression was significantly down-regulated in HCC patient tissues and cell lines. Further functional experiments suggested that Linc-USP16 could directly increase PTEN expression by acting as a competing endogenous RNA (ceRNA) for miR-21 and miR-590-5p. These interactions led to repression of AKT pathway and inhibition of HCC cell proliferation and migration. Conclusion: Thus, our data showed that Linc-USP16, as a tumour suppressor, plays an important role in HCC pathogenesis and provides a new therapeutic strategy for HCC treatment.

scholarly journals Circular RNA-Centered Regulatory Networks in the Physiopathology of Cardiovascular Diseases

2020 ◽  
Vol 21 (2) ◽  
pp. 456 ◽  
Author(s):  
André F. Gabriel ◽  
Marina C. Costa ◽  
Francisco J. Enguita
Keyword(s):  
Cardiovascular Diseases ◽  
Cell Biology ◽  
Regulatory Networks ◽  
Current Knowledge ◽  
Circular Rna ◽  
Non Coding Rna ◽  
Non Coding Rnas ◽  
Regulatory Rnas ◽  
Eukaryotic Genomes

Non-coding regulatory RNAs are generated as a core output of the eukaryotic genomes, being essential players in cell biology. At the organism level, they are key functional actors in those tissues and organs with limited proliferation capabilities such as the heart. The role of regulatory networks mediated by non-coding RNAs in the pathophysiology of cardiovascular conditions is starting to be unveiled. However, a deeper knowledge of the functional interactions among the diverse non-coding RNA families and their phenotypic consequences is required. This review presents the current knowledge about the functional crosstalk between circRNAs and other biomolecules in the framework of the cardiovascular diseases.

scholarly journals CIRCULAR RNA – miRNA MEDIATED INTERACTION IN MYOCARDIAL INFARCTION

2021 ◽  
Vol 27 (2) ◽  
pp. 3793-3798
Author(s):  
Yordanka Doneva ◽  
◽  
Veselin Valkov ◽  
Yavor Kashlov ◽  
Galya Mihaylova ◽  
...  
Keyword(s):  
Gene Expression ◽  
Myocardial Infarction ◽  
Circular Rna ◽  
Biological Functions ◽  
Non Coding Rna ◽  
Circular Structure ◽  
Wide Range ◽  
Non Coding Rnas ◽  
Long Non Coding Rna

Circular RNA (circRNAs) belong to the long non-coding RNA family, but unlike the linear RNA in circular RNA, the 3’ and 5’ end in the RNA molecule are joined together, forming their circular structure. Until recently, circRNAs have been believed to be a side product of splicing, but now it is known that they have a wide range of biological functions, from regulators of gene expression to regulators of other non-coding RNAs - microRNAs (miRNAs). CircRNAs have the potential of being therapeutic targets and biomarkers for diseases. There are little data and only several investigations about this type of RNAs in myocardial infarction in humans. This review summarizes the role of some new circRNA – miRNA interactions in the development of Myocardial Infarction.

scholarly journals Non-coding RNA in cancer

2021 ◽  
Author(s):  
Huiwen Yan ◽  
Pengcheng Bu
Keyword(s):  
Human Genome ◽  
Regulatory Mechanism ◽  
Therapeutic Potential ◽  
Circular Rna ◽  
Non Coding Rna ◽  
Non Coding Rnas

Abstract Majority of the human genome is transcribed to RNAs that do not encode proteins. These non-coding RNAs (ncRNAs) play crucial roles in regulating the initiation and progression of various cancers. Given the importance of the ncRNAs, the roles of ncRNAs in cancers have been reviewed elsewhere. Thus, in this review, we mainly focus on the recent studies of the function, regulatory mechanism and therapeutic potential of the ncRNAs including microRNA (miRNA), long ncRNA (lncRNA), circular RNA (circRNA) and PIWI interacting RNA (piRNA), in different type of cancers.

Advances in biomarkers for HCC

2018 ◽  
Vol 1 (2) ◽  
pp. 29-32 ◽  
Author(s):  
Taya Kitiyakara
Keyword(s):  
Hepatocellular Carcinoma ◽  
Treatment Outcomes ◽  
Alpha Fetoprotein ◽  
Blood Tests ◽  
Common Cancer ◽  
Non Coding Rna ◽  
Non Coding Rnas ◽  
New Biomarkers ◽  
Long Non Coding Rna ◽  
Late Stages

Hepatocellular carcinoma is a common cancer worldwide and has a high mortality. Many patientspresent in the late stages and the outcome of treatment for these patients is poor. Biomarkerscould theoretically help to detect the disease at an earlier stage before symptoms occurand improve the treatment outcomes. The first biomarker found was alpha-fetoprotein (AFP) and it iscurrently used as part of the HCC surveillance recommended in many countries. However AFP isnot very accurate and 30-40% of HCCs may be missed. Currently there are other biomarkers underinvestigation. Most of the more common biomarkers studied are serum/blood tests and include AFP-L3,PIVKA-II, Glypican-2, VEGF and the non-coding RNAs, such as long non-coding RNA and microRNA,and metabolomics tests. Tests involving urine or patient breaths are still relatively uncommonbut are being investigated. The limitation on the use of these new biomarkers is from the availabilityand costs of the tests. Only AFP-L3 and PIVKA-II are currently commercially available.   Keywords: Biomarker, hepatocellular carcinoma, alpha-fetoprotein, microRNA, screening

scholarly journals Exosomes in hepatocellular carcinoma microenvironment and their potential clinical application value

2021 ◽  
Vol 138 ◽  
pp. 111529
Author(s):  
Risheng He ◽  
Zhongrui Wang ◽  
Wenguang Shi ◽  
Liang Yu ◽  
Haoming Xia ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Application ◽  
Potential Clinical Application

scholarly journals The Relationship Between the Network of Non-coding RNAs-Molecular Targets and N6-Methyladenosine Modification in Colorectal Cancer

2021 ◽  
Vol 9 ◽  
Author(s):  
Senxu Lu ◽  
Xiangyu Ding ◽  
Yuanhe Wang ◽  
Xiaoyun Hu ◽  
Tong Sun ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Circular Rna ◽  
Data Driven ◽  
Non Coding Rna ◽  
Regulation Network ◽  
Data Driven Approach ◽  
Non Coding Rnas ◽  
Clinical Potential ◽  
The Relationship ◽  
Long Non Coding Rna

Recent accumulating researches implicate that non-coding RNAs (ncRNAs) including microRNA (miRNA), circular RNA (circRNA), and long non-coding RNA (lncRNAs) play crucial roles in colorectal cancer (CRC) initiation and development. Notably, N6-methyladenosine (m6A) methylation, the critical posttranscriptional modulators, exerts various functions in ncRNA metabolism such as stability and degradation. However, the interaction regulation network among ncRNAs and the interplay with m6A-related regulators has not been well documented, particularly in CRC. Here, we summarize the interaction networks and sub-networks of ncRNAs in CRC based on a data-driven approach from the publications (IF > 6) in the last quinquennium (2016–2021). Further, we extend the regulatory pattern between the core m6A regulators and m6A-related ncRNAs in the context of CRC metastasis and progression. Thus, our review will highlight the clinical potential of ncRNAs and m6A modifiers as promising biomarkers and therapeutic targets for improving the diagnostic precision and treatment of CRC.

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