scholarly journals The first EGF domain of coagulation factor IX attenuates cell adhesion and induces apoptosis

2016 ◽  
Vol 36 (3) ◽  
Author(s):  
Tomomi Ishikawa ◽  
Hisataka Kitano ◽  
Atsushi Mamiya ◽  
Shinichiro Kokubun ◽  
Chiaki Hidai
Keyword(s):  
Extracellular Matrix ◽  
Cell Adhesion ◽  
Growth Factor ◽  
Caspase 3 ◽  
Coagulation Factor ◽  
Factor Ix ◽  
Coagulation Factor Ix ◽  
Epidermal Growth ◽  
Egf Domain ◽  
Induced Apoptosis

Activated coagulation factor IX (FIX) attenuated cell adhesion to the extracellular matrix (ECM) and induced apoptosis. This activity was localized to the first epidermal growth factor (EGF) domain, EGF-F9. Experiments with caspase-3 inhibitors revealed that attenuation of adhesion and apoptosis by EGF-F9 were dependent on caspase-3.

scholarly journals The N-terminal Epidermal Growth Factor-like Domain of Coagulation Factor IX

2002 ◽  
Vol 277 (38) ◽  
pp. 35616-35624 ◽  
Author(s):  
Kristina E. M. Persson ◽  
Bruno O. Villoutreix ◽  
Ann-Marie Thämlitz ◽  
Karin E. Knobe ◽  
Johan Stenflo
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Coagulation Factor ◽  
Factor Ix ◽  
Coagulation Factor Ix ◽  
Epidermal Growth

scholarly journals The Connecting Segment between Both Epidermal Growth Factor-like Domains in Blood Coagulation Factor IX Contributes to Stimulation by Factor VIIIa and Its Isolated A2 Domain

2002 ◽  
Vol 277 (23) ◽  
pp. 20214-20220 ◽  
Author(s):  
Patrick H. N. Celie ◽  
Gunny van Stempvoort ◽  
Caroline Fribourg ◽  
Leon J. Schurgers ◽  
Peter J. Lenting ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Blood Coagulation ◽  
Coagulation Factor ◽  
Factor Ix ◽  
Coagulation Factor Ix ◽  
Factor Viiia ◽  
Epidermal Growth ◽  
A2 Domain
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