scholarly journals Human fallopian tube proteome shows high coverage of mesenchymal stem cells associated proteins

2016 ◽  
Vol 36 (1) ◽  
Author(s):  
Chenyuan Wang ◽  
Yang Liu ◽  
Cheng Chang ◽  
Songfeng Wu ◽  
Jie Gao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Fallopian Tube ◽  
High Abundance ◽  
High Coverage ◽  
Human Fallopian Tube ◽  
Associated Proteins

We report the largest scale MS based proteome of human fallopian tube (hFT). Ribosome, cytoskeleton, and vesicle associated proteins showed high abundance in hFT. Extraordinary high coverage of MSCs associated proteins in the hFT proteome.

scholarly journals Human fallopian tube: a new source of multipotent adult mesenchymal stem cells discarded in surgical procedures

2009 ◽  
Vol 7 (1) ◽  
pp. 46 ◽  
Author(s):  
Tatiana Jazedje ◽  
Paulo M Perin ◽  
Carlos E Czeresnia ◽  
Mariangela Maluf ◽  
Silvio Halpern ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Fallopian Tube ◽  
Surgical Procedures ◽  
Human Fallopian Tube ◽  
Adult Mesenchymal Stem Cells

In vivo osteogenic regenerative potential of human fallopian tube mesenchymal stem cells

2011 ◽  
Vol 96 (3) ◽  
pp. S104
Author(s):  
T. Jazedje ◽  
C.E. Czeresnia ◽  
L.P. Evangelista ◽  
M. Maluf ◽  
P.M. Perin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Fallopian Tube ◽  
Human Fallopian Tube

Mesenchymal stem cells in infantile haemangioma

2011 ◽  
Vol 64 (3) ◽  
pp. 232-236 ◽  
Author(s):  
Tinte Itinteang ◽  
Anasuya Vishvanath ◽  
Darren J Day ◽  
Swee T Tan
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Neural Crest ◽  
Capillary Endothelium ◽  
Fatty Tissue ◽  
Rt Pcr ◽  
Functional Potential ◽  
Infantile Haemangioma ◽  
Mesenchymal Differentiation ◽  
Associated Proteins

BackgroundFibro-fatty deposition commonly occurs during involution of infantile haemangioma (IH). Mesenchymal stem cells have been identified in this tumour and have been proposed to be recruited from the bone marrow and/or adjacent niches, and then give rise to the fibro-fatty tissue. The authors have recently demonstrated that the capillary endothelium of proliferating IH co-expresses primitive mesodermal, mesenchymal and neural crest markers and proposed that this same endothelium has the ability to give rise to cells of mesenchymal lineage that constitute the fibro-fatty deposition.MethodsImmunohistochemistry and real-time RT-PCR were used to further characterise proliferating IHs and haemangioma explant-derived cells (HaemEDCs).ResultsThe authors have further confirmed expression of the mesenchymal-associated proteins including preadipocyte factor-1, a mesenchymal differentiation inhibition-associated cytokine. The HaemEDCs could be differentiated into osteoblasts and adipocytes, indicating their functional potential for terminal differentiation.DiscussionThe collective expression of neural crest, mesenchymal and mesenchymal differentiation inhibition-associated proteins on the endothelium of proliferating IH suggests that the cells in the capillary endothelium within the lesion possess the ability to undergo terminal mesenchymal differentiation during the proliferating phase, but are inhibited from doing so.

scholarly journals Mesenchymal Stem Cells Overexpressing ACE2 Favorably Ameliorate LPS-Induced Inflammatory Injury in Mammary Epithelial Cells

2022 ◽  
Vol 12 ◽  
Author(s):  
Shuping Yan ◽  
Pingsheng Ye ◽  
Muhammad Tahir Aleem ◽  
Xi Chen ◽  
Nana Xie ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Inos Mrna ◽  
Inflammatory Injury ◽  
Expression Levels ◽  
Associated Proteins ◽  
Anti Inflammatory

Mesenchymal stem cells (MSCs) are capable of homing injury sites to exert anti-inflammatory as well as anti-damage effects and can be used as a vehicle for gene therapy. Angiotensin-converting enzyme 2 (ACE2) plays an important role in numerous inflammatory diseases, but fewer studies have been reported in animal mastitis. We hypothesized that MSCs overexpressing ACE2 is more effective in ameliorating lipopolysaccharide (LPS)-induced inflammatory injury in mammary epithelial cells compared to MSCs alone. The results showed that MSC-ACE2 inhibited the LPS induction by upregulation of TNF-α, IL-Iβ, IL-6, and iNOS mRNA expression levels in EpH4-Ev cells compared with MSCs. Furthermore, results showed that both MSC and MSC-ACE2 were significantly activated IL-10/STAT3/SOCS3 signaling pathway as well as inhibited TLR4/NF-κB and MAPK signaling pathways, but MSC-ACE2 had more significant effects. Meanwhile, MSC-ACE2 promoted the expression of proliferation-associated proteins and inhibited the expression of the apoptosis-associated proteins in EpH4-Ev cells. In addition, MSC and MSC-ACE2 reversed the LPS-induced downregulation expression levels of the tight junction proteins in mammary epithelial cells, indicating that both MSC as well as MSC-ACE2 could promote blood-milk barrier repair, and MSC-ACE2 was more effective. These results suggested that MSCs overexpressing ACE2 were more anti-inflammatory as well as anti-injurious action into LPS-induced inflammatory injury in the EpH4-Ev cells. Thus, MSCs overexpressing ACE2 is expected to serve as a potential strategy for mastitis treatment.

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