scholarly journals Lentivirus-mediated knockdown of eukaryotic translation initiation factor 3 subunit D inhibits proliferation of HCT116 colon cancer cells

2014 ◽  
Vol 34 (6) ◽  
Author(s):  
Xiaojun Yu ◽  
Bo’an Zheng ◽  
Rui Chai
Keyword(s):  
Colon Cancer ◽  
Translation Initiation ◽  
Colon Cancer Cell ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Colon Cancer Cells ◽  
Cancer Cell Growth ◽  
Eukaryotic Translation ◽  
Eukaryotic Translation Initiation ◽  
Translation Initiation Factor 3

eIF3D is essential for colon cancer cell growth, and knockdown of eIF3D resulted in a significant reduction in cell proliferation probably due to activation of AMPKα, Bad, PRAS40, SAPK/JNK and GSK3β, as well as cleavage of PARP.

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