scholarly journals Modulation of intrahepatic cholesterol trafficking: evidence by in vivo antisense treatment for the involvement of sterol carrier protein-2 in newly synthesized cholesterol transport into rat bile

1998 ◽  
Vol 331 (3) ◽  
pp. 975-975
Author(s):  
L. PUGLIELLI ◽  
A. RIGOTTI ◽  
L. AMIGO ◽  
L. NUÑEZ ◽  
A. V. GRECO ◽  
...  
Keyword(s):  
Cholesterol Transport ◽  
Carrier Protein ◽  
Sterol Carrier Protein ◽  
Cholesterol Trafficking ◽  
Sterol Carrier Protein 2 ◽  
Rat Bile

Cholesterol transport mediated by sterol carrier protein 2 (SCP2)

1994 ◽  
Vol 109 (1-2) ◽  
pp. 174
Author(s):  
U. Seedorf ◽  
P. Brysch ◽  
T. Engel ◽  
S. Scheek ◽  
M. Raabe ◽  
...  
Keyword(s):  
Cholesterol Transport ◽  
Carrier Protein ◽  
Sterol Carrier Protein ◽  
Sterol Carrier Protein 2

scholarly journals In Vivo Functional Genomic Studies of Sterol Carrier Protein-2 Gene in the Yellow Fever Mosquito

PLoS ONE ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. e18030 ◽  
Author(s):  
Rong Peng ◽  
Vilena I. Maklokova ◽  
Jayadevi H. Chandrashekhar ◽  
Que Lan
Keyword(s):  
Yellow Fever ◽  
Carrier Protein ◽  
Functional Genomic ◽  
Sterol Carrier Protein ◽  
Yellow Fever Mosquito ◽  
Genomic Studies ◽  
Sterol Carrier Protein 2

scholarly journals Modulation of intrahepatic cholesterol trafficking: evidence by in vivo antisense treatment for the involvement of sterol carrier protein-2 in newly synthesized cholesterol transport into rat bile

1996 ◽  
Vol 317 (3) ◽  
pp. 681-687 ◽  
Author(s):  
Luigi PUGLIELLI ◽  
Attilio RIGOTTI ◽  
Ludwig AMIGO ◽  
Liliana NUÑEZ ◽  
Aldo V. GRECO ◽  
...  
Keyword(s):  
Time Course ◽  
Molecular Mechanisms ◽  
Cholesterol Gallstone ◽  
The Body ◽  
Biliary Secretion ◽  
Carrier Protein ◽  
Sterol Carrier Protein ◽  
Biliary Cholesterol ◽  
Sterol Carrier Protein 2

Biliary cholesterol represents one of the two major excretory pathways for sterol elimination from the body and plays a central role in cholesterol gallstone formation. Biliary cholesterol originates from a precursor pool of preformed and newly synthesized free cholesterol. Although it has been suggested that newly synthesized and preformed biliary cholesterol are secreted by independent pathways, the specific cellular and molecular mechanisms are unknown. We used male Wistar rats to study the time-course of the appearance of newly synthesized cholesterol, phosphatidylcholine and protein into bile. The specific role of sterol carrier protein-2 (SCP-2) in the transport of newly synthesized biliary cholesterol was evaluated by an in vivo antisense oligonucleotide approach. In contrast to [14C]phosphatidylcholine and [35S]proteins, the time-course of [14C]cholesterol appearance into bile was rapid, and microtubule- and Golgi-independent. In vivo SCP-2 antisense treatment reduced and delayed the appearance of biliary [14C]cholesterol. Furthermore, hepatic SCP-2 expression increased more than 3-fold over control values in rats that had been treated with diosgenin to increase biliary secretion of newly synthesized cholesterol. These results suggest that SCP-2 is necessary for the rapid transport of newly synthesized cholesterol into bile and that hepatocytes can induce SCP-2 expression according to the rate of biliary secretion of newly synthesized cholesterol.

scholarly journals Sterol Carrier Protein-2 Directly Interacts with Caveolin-1 in Vitro and in Vivo†

Biochemistry ◽  
2004 ◽  
Vol 43 (23) ◽  
pp. 7288-7306 ◽  
Author(s):  
Minglong Zhou ◽  
Rebecca D. Parr ◽  
Anca D. Petrescu ◽  
H. Ross Payne ◽  
Barbara P. Atshaves ◽  
...  
Keyword(s):  
Carrier Protein ◽  
Sterol Carrier Protein ◽  
Caveolin 1 ◽  
Sterol Carrier Protein 2
Sign in / Sign up

Export Citation Format

Share Document