scholarly journals Determination of the structure of an N-substituted protoporphyrin isolated from the livers of griseofulvin-fed mice

1995 ◽  
Vol 307 (2) ◽  
pp. 505-512 ◽  
Author(s):  
R M A Bellingham ◽  
A H Gibbs ◽  
F de Matteis ◽  
L Y Lian ◽  
G C K Roberts
Keyword(s):  
Zinc Complex ◽  
Pyrrole Ring ◽  
Protoporphyrin Ix ◽  
Free Base ◽  
Mechanism Of Formation ◽  
Ring Nitrogen ◽  
Green Pigments ◽  
Anti Fungal ◽  
Pyrrole Nitrogen

Feeding mice with griseofulvin, a widely used anti-fungal agent which induces protoporphyria as a side-effect, leads to the formation in the liver of two green pigments which have been shown to be porphyrin adducts. In this work, the major porphyrin adduct isolated from the livers of griseofulvin-fed mice has been characterized structurally using one- and two-dimensional NMR spectroscopy. The adduct was shown to be an N-alkylated protoporphyrin IX in which the whole of griseofulvin (less a hydrogen atom) is attached to a pyrrole ring nitrogen of the porphyrin. It was shown that the drug-to-porphyrin linkage is an an -O-CH2-Npyrrole = linkage, to either the 4- or 6-position of ring a of griseofulvin. In an attempt to identify which pyrrole nitrogen is involved in this linkage, the 1H spectra of the free base and zinc complex of the adduct were compared with the corresponding spectra of the four regioisomers of N-methylprotoporphyrin. These comparisons indicated that the adduct isolated from the livers of griseofulvin-fed mice is either the NC or the ND regioisomer, although a clear distinction between these two could not be made on the available evidence. The mechanism of formation of the adduct and its relation to griseofulvin-induced protoporphyria are discussed.

Controlled Growth and Characterization Ag/ZnO Nanotetrapods for Humidity Sensing

2018 ◽  
Vol 21 (7) ◽  
pp. 462-467
Author(s):  
Babak Sadeghi
Keyword(s):  
Room Temperature ◽  
Zinc Complex ◽  
Water Solution ◽  
Particle Morphology ◽  
Quick Response ◽  
Separation System ◽  
Humidity Sensing ◽  
Sensor Material ◽  
Highly Sensitive

Aim and Objective: Ultrafine Ag/ZnO nanotetrapods (AZNTP) have been prepared successfully using silver (I)–bis (oxalato) zinc complex and 1, 3-diaminopropane (DAP) with a phase separation system, and have been injected into a diethyl/water solution. Materials and Methods: This crystal structure and lattice constant of the AZNTP obtained were investigated by means of a SEM, XRD, TEM and UV-vis spectrum. Results: The results of the present study demonstrated the growth and characterization AZNTP for humidity sensing and DAP plays a key role in the determination of particle morphology. AZNTP films with 23 nm in arm diameter have shown highly sensitive, quick response sensor material that works at room temperature.

Determination of the minimum suppressive concentration of photosensitizers of the second generation in relation to sanitaryindicative microorganisms

2021 ◽  
Vol 1 (11) ◽  
pp. 42-46
Author(s):  
Vadim Yu. Shlenskiy ◽  
◽  
Tatiana I. Pashnik ◽  
Svetlana Yu. Pigina ◽  
◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Salmonella Enteritidis ◽  
Second Generation ◽  
Research Work ◽  
Protoporphyrin Ix ◽  
Bactericidal Effect ◽  
Disodium Salt ◽  
Bacterial Cultures

In the studies described in the article, the presence of antimicrobial activity in photosensitizers in experiments on bacterial cultures was confirmed. In the experiments, photosensitizers of the second generation were used: «Photoditazine», the active substance of which is dimeglumin chloride E6, and «Dimegin», which includes a derivative of protoporphyrin IX-2,4-di(1-methoxyethyl)- deuteroporphyrin IX disodium salt. In the described research work, the minimum concentrations of the studied drugs were determined by the method of sequential tenfold dilutions to obtain a bactericidal effect on strains of sanitary-indicative microorganisms Enterococcus faecalis, Staphylococcus aureus, Salmonella enteritidis.

Free-base corroles: determination of deprotonation constants in non-aqueous media

2007 ◽  
Vol 11 (04) ◽  
pp. 269-276 ◽  
Author(s):  
Jing Shen ◽  
Zhongping Ou ◽  
Jianguo Shao ◽  
Michał Gałęzowski ◽  
Daniel T. Gryko ◽  
...  
Keyword(s):  
Equilibrium Constants ◽  
Aqueous Media ◽  
Free Base ◽  
Organic Base ◽  
Experimental Conditions ◽  
Spectral Changes ◽  
Base Analysis ◽  
Uv Visible ◽  
The Given

A series of free-base corroles with different electron-donating or electron-withdrawing substituents were reacted with piperidine, 4-aminopyridine, 2-methylimidazole, 2-aminopyridine or pyridine in PhCN and the UV-visible spectral changes monitored during conversion of ( Cor ) H 3 to [( Cor ) H 2]- as a function of the concentration and strength of the added organic base. Analysis of the UV-visible spectral changes as a function of the added base concentration enabled calculation of equilibrium constants ( logK ) for deprotonation of each corrole under the given experimental conditions. Relationships are examined between the experimentally measured logK values and previously published spectroscopic and structural properties of the compounds.

Electron capture by some molecules of biological significance and the determination of absolute electron affinities

1968 ◽  
Vol 21 (12) ◽  
pp. 2853 ◽  
Author(s):  
A Fulton ◽  
LE Lyons ◽  
GC Morris
Keyword(s):  
Electron Capture ◽  
Protoporphyrin Ix ◽  
Biological Significance ◽  
Molecular Orbitals ◽  
Electron Affinities ◽  
Metal Free ◽  
Capture Method

The electron capture method was applied to protoporphyrin IX and meso- porphyrin IX dimethyl esters, metal-free phthalocyanine, chlorophyll, riboflavine, nicotinamide, tetracene, and pentacene. The energy quantities obtained correlated with calculated energies of the lowest empty molecular orbitals of these molecules.

scholarly journals STRUCTURAL AND MOLECULAR DETERMINATION OF A ZINC COMPLEX WITH SCHIFF BASE

2015 ◽  
Author(s):  
S. F. F. Santos ◽  
C. A. Wegermann ◽  
M. S. Monsalve ◽  
C. A. Simone ◽  
A. M. C. Ferreira ◽  
...  
Keyword(s):  
Schiff Base ◽  
Zinc Complex ◽  
Molecular Determination

Colorimetric assay for the rapid determination of free-base nicotine in e-liquid

2020 ◽  
Vol 12 (2) ◽  
pp. 193-199
Author(s):  
Yan-Jun Huang ◽  
Qi-Xin Deng ◽  
Hong-Qiao Lan ◽  
Zheng-Zhong Fang ◽  
Hui Chen ◽  
...  
Keyword(s):  
Rapid Determination ◽  
Colorimetric Assay ◽  
Water Soluble ◽  
Free Base ◽  
Base Form

Nicotine exists in e-liquids primarily as the monoprotonated form and free-base form. The free-base form could be evaluated by use of a water-soluble indicator.

scholarly journals Investigations on Natural Surfactant obtained from Soap-Nuts through Spectrophotometric Interactions with Congo Red and Comparison with Commercial Surfactants

2019 ◽  
Vol 31 (4) ◽  
pp. 907-916
Author(s):  
M.C. Somasekhara Reddy ◽  
S.M. Sarvar Jahan ◽  
K. Sridevi ◽  
G.V. Subba Reddy
Keyword(s):  
Congo Red ◽  
Sodium Dodecyl ◽  
Mechanism Of Formation ◽  
Surfactant Micelles ◽  
Natural Surfactant ◽  
Fruit Pericarp ◽  
Direct Dye ◽  
The Stability ◽  
Triton X

A natural surfactant (NS) of plant-base was obtained from the fruit pericarp of soapnuts by using a simple and economical method. The interaction of this natural surfactant with direct dye, anionic dye, Congo red (CR) was studied spectrophotometrically in sub-micellar and micelle concentration range in aqueous solution. These interactions (CR-NS) were compared with that of CR-CTAB (cationic surfactant-cetyl trimethylammonium bromide, CTAB), CR-SDS (anionic surfactant-sodium dodecyl sulphate, SDS) and CR-TX 100 (neutral surfactant - Triton X-100, TX 100) and were useful to understand the nature of natural surfactant. The mechanism of formation of complex due to interactions between Congo red and natural surfactant was suggested. This spectrophotometric method was used for the determination of critical micelle concentration (CMC), at which the formation of micelles was started. The CMC values obtained spectrophotometrically for the natural surfactant was coincided with the experimental value available in the literature. A definite change in the absorbance maxima of Congo red in the presence of natural surfactant (micelles of natural surfactant) was also observed. The change in maxima was also interpreted in terms of pH and CMC. The equilibrium constant of interaction between Congo red and natural surfactant was calculated on the theoretical model. The stability of the complexes of Congo red with different surfactants like CTAB, SDS, TX 100 and natural surfactant may be written in increasing order as: CR-TX 100 > CR-CTAB > CR-NS > CR-SDS. The biodegradable, non-toxic, inexpensive, environmental friendly, renewable natural surfactant was suggested in place of synthetic surfactants.

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