scholarly journals Analysis of algebraic weighted least-squares estimators for enzyme parameters

1992 ◽  
Vol 288 (2) ◽  
pp. 533-538 ◽  
Author(s):  
M E Jones
Keyword(s):  
Least Squares ◽  
Coefficient Of Variation ◽  
Constant Coefficient ◽  
Weighted Least Squares ◽  
Simulated Data ◽  
Standard Errors ◽  
Parameter Estimates ◽  
Spreadsheet Program ◽  
Least Squares Estimators ◽  
Constant Coefficient Of Variation

An algorithm for the least-squares estimation of enzyme parameters Km and Vmax. is proposed and its performance analysed. The problem is non-linear, but the algorithm is algebraic and does not require initial parameter estimates. On a spreadsheet program such as MINITAB, it may be coded in as few as ten instructions. The algorithm derives an intermediate estimate of Km and Vmax. appropriate to data with a constant coefficient of variation and then applies a single reweighting. Its performance using simulated data with a variety of error structures is compared with that of the classical reciprocal transforms and to both appropriately and inappropriately weighted direct least-squares estimators. Three approaches to estimating the standard errors of the parameter estimates are discussed, and one suitable for spreadsheet implementation is illustrated.

scholarly journals A New Inverted Topp-Leone Distribution: Applications to the COVID-19 Mortality Rate in Two Different Countries

Axioms ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 25 ◽  
Author(s):  
Ehab Almetwally ◽  
Randa Alharbi ◽  
Dalia Alnagar ◽  
Eslam Hafez
Keyword(s):  
Statistical Model ◽  
Least Squares ◽  
Weighted Least Squares ◽  
Likelihood Estimation ◽  
Linear Representation ◽  
Rate Function ◽  
Estimation Methods ◽  
Unknown Parameters ◽  
Least Squares Estimators ◽  
New Distribution

This paper aims to find a statistical model for the COVID-19 spread in the United Kingdom and Canada. We used an efficient and superior model for fitting the COVID 19 mortality rates in these countries by specifying an optimal statistical model. A new lifetime distribution with two-parameter is introduced by a combination of inverted Topp-Leone distribution and modified Kies family to produce the modified Kies inverted Topp-Leone (MKITL) distribution, which covers a lot of application that both the traditional inverted Topp-Leone and the modified Kies provide poor fitting for them. This new distribution has many valuable properties as simple linear representation, hazard rate function, and moment function. We made several methods of estimations as maximum likelihood estimation, least squares estimators, weighted least-squares estimators, maximum product spacing, Crame´r-von Mises estimators, and Anderson-Darling estimators methods are applied to estimate the unknown parameters of MKITL distribution. A numerical result of the Monte Carlo simulation is obtained to assess the use of estimation methods. also, we applied different data sets to the new distribution to assess its performance in modeling data.

Understanding change in hydrometeorological extremes with statistical models - the importance of model parametrization

2021 ◽  
Author(s):  
Ilaria Prosdocimi ◽  
Thomas Kjeldsen
Keyword(s):  
Coefficient Of Variation ◽  
Constant Coefficient ◽  
River Flow ◽  
Extreme Value ◽  
Flow Measurements ◽  
Scaling Properties ◽  
Distribution Parameters ◽  
Quantile Estimates ◽  
Constant Coefficient Of Variation ◽  
The Impact

<p>The potential for changes in hydrometeorological extremes is routinely investigated by fitting change-permitting extreme value models to long-term observations, allowing one or more distribution parameters to change as a function of time or some physically-motivated covariate. In most practical extreme value analyses, the main quantity of interest though is the upper quantiles of the distribution, rather than the parameters' values. This study focuses on the changes in quantile estimates under different change-permitting models. First, metrics which measure the impact of changes in parameters on changes in quantiles are introduced. The mathematical structure of these change metrics is investigated for several models based on the Generalised Extreme Value (GEV) distribution. It is shown that for the most commonly used models, the predicted changes in the quantiles are a non-intuitive function of the distribution parameters, leading to results which are difficult to interpret. Next, it is posited that commonly used change-permitting GEV models do not preserve a constant coefficient of variation, a property that is typically assumed to hold and that is related to the scaling properties of extremes. To address these shortcomings a new (parsimonious) model is proposed: the model assumes a constant coefficient of variation, allowing the location and scale parameters to change simultaneously. The proposed model results in more interpretable changes in the quantile function. The consequences of the different modelling choices on quantile estimates are exemplified using a dataset of extreme peak river flow measurements.</p>

scholarly journals Multivariate approximation of functions on irregular domains by weighted least-squares methods

2020 ◽  
Author(s):  
Giovanni Migliorati
Keyword(s):  
Least Squares ◽  
Orthonormal Basis ◽  
Weighted Least Squares ◽  
Computational Cost ◽  
Numerical Algorithms ◽  
Analytic Form ◽  
Multivariate Approximation ◽  
Irregular Domain ◽  
Least Squares Estimators ◽  
Dimensional Approximation

Abstract We propose and analyse numerical algorithms based on weighted least squares for the approximation of a bounded real-valued function on a general bounded domain $\varOmega \subset \mathbb{R}^d$. Given any $n$-dimensional approximation space $V_n \subset L^2(\varOmega )$, the analysis in Cohen and Migliorati (2017, Optimal weighted least-squares methods. SMAI J. Comput. Math., 3, 181–203) shows the existence of stable and optimally converging weighted least-squares estimators, using a number of function evaluations $m$ of the order $n \ln n$. When an $L^2(\varOmega )$-orthonormal basis of $V_n$ is available in analytic form, such estimators can be constructed using the algorithms described in Cohen and Migliorati (2017, Optimal weighted least-squares methods. SMAI J. Comput. Math., 3, 181–203, Section 5). If the basis also has product form, then these algorithms have computational complexity linear in $d$ and $m$. In this paper we show that when $\varOmega $ is an irregular domain such that the analytic form of an $L^2(\varOmega )$-orthonormal basis is not available, stable and quasi-optimally weighted least-squares estimators can still be constructed from $V_n$, again with $m$ of the order $n \ln n$, but using a suitable surrogate basis of $V_n$ orthonormal in a discrete sense. The computational cost for the calculation of the surrogate basis depends on the Christoffel function of $\varOmega $ and $V_n$. Numerical results validating our analysis are presented.

scholarly journals Parametrisation of change-permitting extreme value models and its impact on the description of change

2020 ◽  
Author(s):  
Ilaria Prosdocimi ◽  
Thomas Kjeldsen
Keyword(s):  
Coefficient Of Variation ◽  
Constant Coefficient ◽  
River Flow ◽  
Extreme Value ◽  
Flow Measurements ◽  
Environmental Extremes ◽  
Distribution Parameters ◽  
Quantile Estimates ◽  
Constant Coefficient Of Variation ◽  
The Impact

AbstractThe potential for changes in environmental extremes is routinely investigated by fitting change-permitting extreme value models to long-term observations, allowing one or more distribution parameters to change as a function of time or some other covariate. In most extreme value analyses, the main quantity of interest is typically the upper quantiles of the distribution, which are often needed for practical applications such as engineering design. This study focuses on the changes in quantile estimates under different change-permitting models. First, metrics which measure the impact of changes in parameters on changes in quantiles are introduced. The mathematical structure of these change metrics is investigated for several change-permitting models based on the Generalised Extreme Value (GEV) distribution. It is shown that for the most commonly used models, the predicted changes in the quantiles are a non-intuitive function of the distribution parameters, leading to results which are difficult to interpret. Next, it is posited that commonly used change-permitting GEV models do not preserve a constant coefficient of variation, a property that is typically assumed to hold for environmental extremes. To address these shortcomings a new (parsimonious) model is proposed: the model assumes a constant coefficient of variation, allowing the location and scale parameters to change simultaneously. The proposed model results in changes in the quantile function that are easier to interpret. Finally, the consequences of the different modelling choices on quantile estimates are exemplified using a dataset of extreme peak river flow measurements in Massachusetts, USA. It is argued that the decision on which model structure to adopt to describe change in extremes should also take into consideration any requirements on the behaviour of the quantiles of interest.

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