scholarly journals Chain-length dependency of interactions of medium-chain fatty acids with glucose metabolism in acini isolated from lactating rat mammary glands. A putative feed-back to control milk lipid synthesis from glucose

1992 ◽  
Vol 281 (1) ◽  
pp. 273-278 ◽  
Author(s):  
K J Heesom ◽  
P F A Souza ◽  
V Ilic ◽  
D H Williamson
Keyword(s):  
Fatty Acids ◽  
Glucose Metabolism ◽  
Glucose Utilization ◽  
Lipid Synthesis ◽  
Mammary Glands ◽  
Milk Lipid ◽  
Medium Chain ◽  
Medium Chain Fatty Acids ◽  
Control Milk ◽  
Chain Fatty Acids

The effects of a series of medium-chain fatty acids (C6-C12) on glucose metabolism in isolated acini from lactating rat mammary glands have been studied. Hexanoate (C6) octanoate (C8) and decanoate (C10), but not laurate (C12), decreased [1-14C]glucose conversion into [14C]lipid and the production of 14CO2 (an index of the pentose phosphate pathway). With hexanoate and octanoate, glucose utilization was decreased, whereas decanoate had a slight stimulatory effect on glucose utilization, but there was a large accumulation of lactate. Addition of dichloroacetate (an inhibitor of pyruvate dehydrogenase kinase) decreased this accumulation of lactate and stimulated the conversion of [1-14C]glucose into [14C]lipid and 14CO2. Insulin had no effect on the rate of glucose utilization in the presence of hexanoate. It stimulated the rate in the presence of octanoate and laurate and increased the conversion of [1-14C]glucose into [14C]lipid in the presence of octanoate, decanoate or laurate. The major fate of 1-14C-labelled medium-chain fatty acids (C6, C8 and C12) was conversion into [14C]lipid. The proportion converted into 14CO2 decreased with increasing chain length, whereas the rate of [14C]lipid formation increased. It is concluded that the interactions between medium-chain fatty acids and glucose metabolism represent a feed-back mechanism to control milk lipid synthesis, and this may be important when milk accumulates in the gland.

scholarly journals Biosynthesis of medium-chain fatty acids by mammary epithelial cells from virgin rats

1983 ◽  
Vol 212 (1) ◽  
pp. 155-159 ◽  
Author(s):  
S Smith ◽  
D Pasco ◽  
S Nandi
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Fatty Acid Synthetase ◽  
Mammary Glands ◽  
Mammary Epithelial ◽  
Medium Chain ◽  
Medium Chain Fatty Acids ◽  
Chain Fatty Acids

Epithelial cells were isolated from the undifferentiated mammary glands of mature virgin female rats, and their lipogenic characteristics were studied. These cells synthesized predominantly medium-chain fatty acids, albeit at a low rate. In contrast, whole tissue from mammary glands of virgin rats synthesized predominantly long-chain fatty acids at a relatively higher rate, indicating that the lipogenic activity is dominated by the adipocyte component of the gland. Enzyme assays revealed that thioesterase II, the enzyme which regulates production of medium-chain fatty acids by the fatty acid synthetase, was present at a high activity in the undifferentiated mammary epithelial cells of virgin rats. Immunohistochemical studies confirmed this observation and showed that the regulatory enzyme was present exclusively in the epithelial cells lining the alveolar and ductal elements of the undifferentiated gland. This study demonstrates that the potential to elaborate tissue-specific medium-chain fatty acids is already expressed in the undifferentiated tissue of virgin rats and is not acquired as a result of the differentiation associated with the lactogenic phase of development. In this species mammary epithelial cells apparently synthesize predominantly medium-chain fatty acids at all stages of development, and only the overall rate of synthesis is increased on induction of the fatty acid synthetase during lactogenesis.

Enhanced Bioavailability of Curcumin Nanoemulsions Stabilized with Phosphatidylcholine Modified with Medium Chain Fatty Acids

2017 ◽  
Vol 14 (3) ◽  
pp. 377-385 ◽  
Author(s):  
Angelica A. Ochoa-Flores ◽  
Josafat A. Hernández-Becerra ◽  
Adriana Cavazos-Garduño ◽  
Ida Soto-Rodríguez ◽  
Maria Guadalupe Sanchez-Otero ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Medium Chain ◽  
Medium Chain Fatty Acids ◽  
Chain Fatty Acids

scholarly journals Effects of ketogenic diet containing medium-chain fatty acids on serum inflammatory factor and mTOR signaling pathway in rats

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Huan Liu ◽  
Jingwei Huang ◽  
Hui Liu ◽  
Feng Li ◽  
Quansheng Peng ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Caloric Restriction ◽  
Ketogenic Diet ◽  
Mtor Pathway ◽  
Inflammatory Factor ◽  
Medium Chain ◽  
Medium Chain Fatty Acids ◽  
Sd Rats ◽  
Anti Inflammatory ◽  
Chain Fatty Acids

Abstract Background The ketogenic diet (KD) can promote the anti-inflammatory metabolic state and increase ketone body level in rats. This study was to explore the effects and differences of KD with or without medium-chain fatty acids (MCFAs) on serum inflammatory factors and mTOR pathway in Sprague–Dawley (SD) rats. Results Male SD rats were assigned to five groups: control diet (C), 20% caloric restriction diet (LC), 20% caloric restriction ketogenic diet (containing MCFAs) (LCKD1), 20% caloric restriction ketogenic diet (LCKD2) and 20% caloric restriction foreign ketogenic diet (LCKD3), and fed for 30 d. LC and KD could significantly reduce the body weight of rats; LC and KD containing MCFAs showed anti-inflammatory effects; KD without MCFAs decreased the concentration of mTOR1, while KD containing MCFAs decreased the expression of AMPK, mtor1 and P70sk. Conclusions KD containing MCFAs showed better effects on the mTOR pathway and anti-inflammation than that without MCFAs.

Determination of free medium-chain fatty acids in beer by stir bar sorptive extraction

2008 ◽  
Vol 1196-1197 ◽  
pp. 96-99 ◽  
Author(s):  
Tomáš Horák ◽  
Jiří Čulík ◽  
Marie Jurková ◽  
Pavel Čejka ◽  
Vladimír Kellner
Keyword(s):  
Fatty Acids ◽  
Stir Bar Sorptive Extraction ◽  
Free Medium ◽  
Medium Chain ◽  
Medium Chain Fatty Acids ◽  
Sorptive Extraction ◽  
Chain Fatty Acids

Recovery of volatile fatty acids from water using medium-chain fatty acids and a cosolvent

2017 ◽  
Vol 165 ◽  
pp. 74-80 ◽  
Author(s):  
Marisa A.A. Rocha ◽  
Sona Raeissi ◽  
Patrick Hage ◽  
Wilko M.A. Weggemans ◽  
Jaap van Spronsen ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Volatile Fatty Acids ◽  
Medium Chain ◽  
Medium Chain Fatty Acids ◽  
Chain Fatty Acids
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