scholarly journals Lack of V1 vasopressin receptors in rabbit hepatocytes

1989 ◽  
Vol 259 (2) ◽  
pp. 609-611 ◽  
Author(s):  
A Vandekerckhove ◽  
F Miot ◽  
S Keppens ◽  
H De Wulf
Keyword(s):  
Plasma Membranes ◽  
Rat Hepatocytes ◽  
Rabbit Liver ◽  
Binding Studies ◽  
Liver Plasma Membranes ◽  
Vasopressor Agent ◽  
Vasopressin Receptors

Vasopressin does not induce glycogenolysis in rabbit hepatocytes; glucagon, angiotensin, phenylephrine and ATP are as potent as with rat hepatocytes, whereas isoprenaline is nearly 10000 times more potent in the rabbit. Binding studies of [3H]vasopressin reveal the complete absence of specific vasopressin receptors on rabbit liver plasma membranes. We verified that vasopressin acts as an antidiuretic and vasopressor agent in the rabbit. We conclude that there is a selective lack of V1 vasopressin receptors in rabbit liver.

Phenobarbital Induction of Cytochrome P-450 and UDPGlucuronosyltransferase in Rabbit Liver Plasma Membranes

Enzyme ◽  
1982 ◽  
Vol 28 (1) ◽  
pp. 41-47 ◽  
Author(s):  
Jacques Magdalou ◽  
Bénédicte Antoine ◽  
Damrong Ratanasavanh ◽  
Gérard Siest
Keyword(s):  
Plasma Membranes ◽  
Rabbit Liver ◽  
Liver Plasma Membranes ◽  
Cytochrome P 450 ◽  
Phenobarbital Induction

Growth Hormone and Prolactin Binding to Rabbit Liver Plasma Membranes

1981 ◽  
Vol 13 (09) ◽  
pp. 510-515 ◽  
Author(s):  
J. Fix ◽  
Paula Leppert ◽  
W. Moore
Keyword(s):  
Growth Hormone ◽  
Plasma Membranes ◽  
Rabbit Liver ◽  
Liver Plasma Membranes

scholarly journals Lack of vasopressin receptors in liver, but not in kidney, of ob/ob mice

1983 ◽  
Vol 216 (2) ◽  
pp. 475-480 ◽  
Author(s):  
F Assimacopoulos-Jeannet ◽  
B Cantau ◽  
G van de Werve ◽  
S Jard ◽  
B Jeanrenaud
Keyword(s):  
Plasma Membrane ◽  
Adenylate Cyclase ◽  
Plasma Membranes ◽  
Metabolic Response ◽  
Isolated Hepatocytes ◽  
The Other ◽  
Kidney Medulla ◽  
Liver Plasma Membrane ◽  
Liver Plasma Membranes ◽  
Vasopressin Receptors

The activity of phosphorylase a was measured in isolated hepatocytes from fed lean and ob/ob mice after addition of vasopressin, angiotensin, phenylephrine and glucagon. The binding of these hormones to purified liver plasma membranes was also determined. In hepatocytes of ob/ob mice, no increase in phosphorylase a was measured after addition of vasopressin, whereas the other hormones promoted an increase in the activity of the enzyme. No specific vasopressin receptors could be measured on purified liver plasma membrane of ob/ob mice. A decrease in the number of receptors for angiotensin and glucagon, without modification of the affinity, was also observed. No restoration of the number of vasopressin receptors was observed in liver of ob/ob mice starved for 3 days or in younger (5-6 weeks) animals. Vasopressin receptors and vasopressin-stimulated adenylate cyclase, measured on purified kidney medulla membranes, were similar in both lean and ob/ob mice. The data indicate a selective lack of vasopressin receptors and metabolic response in liver of the ob/ob mouse.

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