scholarly journals Effects of diet on the function of sarcoplasmic reticulum

1987 ◽  
Vol 245 (3) ◽  
pp. 751-755 ◽  
Author(s):  
G W Gould ◽  
J M McWhirter ◽  
J M East ◽  
A G Lee
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Acyl Chain ◽  
Phospholipid Composition ◽  
Fatty Acyl ◽  
Fatty Acyl Chain ◽  
Rabbit Muscle ◽  
Phospholipid Classes ◽  
Chain Composition ◽  
Acyl Chain Composition ◽  
Uptake And Release

We have examined the effect of diet on the phospholipid composition of the sarcoplasmic reticulum of rabbit muscle. Enriching the diet with corn or fish oil results in significant changes in the fatty acyl chain composition of the various phospholipid classes, with relatively little change in the relative contents of the phospholipids. These alterations in composition have no significant effect on the ATPase activity of vesicles of sarcoplasmic reticulum or on the pattern of Ca2+ uptake and release.

scholarly journals Phospholipid (diacyl, alkylacyl, alkenylacyl) and fatty acyl chain composition in murine mastocytoma cells.

1985 ◽  
Vol 26 (9) ◽  
pp. 1134-1141 ◽  
Author(s):  
S Yoshioka ◽  
S Nakashima ◽  
Y Okano ◽  
H Hasegawa ◽  
A Ichiyama ◽  
...  
Keyword(s):  
Acyl Chain ◽  
Fatty Acyl ◽  
Fatty Acyl Chain ◽  
Chain Composition ◽  
Acyl Chain Composition ◽  
Mastocytoma Cells

Body size related adaptations of the avian myocardial phospholipid fatty acyl chain composition

2006 ◽  
Vol 144 (4) ◽  
pp. 496-502 ◽  
Author(s):  
András Szabó ◽  
Hedvig Fébel ◽  
Miklós Mézes ◽  
Krisztián Balogh ◽  
Péter Horn ◽  
...  
Keyword(s):  
Body Size ◽  
Acyl Chain ◽  
Fatty Acyl ◽  
Fatty Acyl Chain ◽  
Chain Composition ◽  
Acyl Chain Composition

scholarly journals Phospholipid Remodeling in Physiology and Disease

2019 ◽  
Vol 81 (1) ◽  
pp. 165-188 ◽  
Author(s):  
Bo Wang ◽  
Peter Tontonoz
Keyword(s):  
Viral Infections ◽  
De Novo ◽  
Acyl Chain ◽  
Phospholipid Composition ◽  
Fatty Acyl ◽  
De Novo Lipogenesis ◽  
Lipid Absorption ◽  
Fatty Acyl Chain ◽  
Nonalcoholic Fatty Liver ◽  
Acyl Chains

Phospholipids are major constituents of biological membranes. The fatty acyl chain composition of phospholipids determines the biophysical properties of membranes and thereby affects their impact on biological processes. The composition of fatty acyl chains is also actively regulated through a deacylation and reacylation pathway called Lands’ cycle. Recent studies of mouse genetic models have demonstrated that lysophosphatidylcholine acyltransferases (LPCATs), which catalyze the incorporation of fatty acyl chains into the sn-2 site of phosphatidylcholine, play important roles in pathophysiology. Two LPCAT family members, LPCAT1 and LPCAT3, have been particularly well studied. LPCAT1 is crucial for proper lung function due to its role in pulmonary surfactant biosynthesis. LPCAT3 maintains systemic lipid homeostasis by regulating lipid absorption in intestine, lipoprotein secretion, and de novo lipogenesis in liver. Mounting evidence also suggests that changes in LPCAT activity may be potentially involved in pathological conditions, including nonalcoholic fatty liver disease, atherosclerosis, viral infections, and cancer. Pharmacological manipulation of LPCAT activity and membrane phospholipid composition may provide new therapeutic options for these conditions.

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