scholarly journals The effect of excess mevalonic acid on ubiquinone and tetrahymanol biosynthesis in Tetrahymena pyriformis

1985 ◽  
Vol 229 (2) ◽  
pp. 551-553 ◽  
Author(s):  
D C Wilton
Keyword(s):  
Mevalonic Acid ◽  
Tetrahymena Pyriformis ◽  
Major Product ◽  
Mevalonic Acid Pathway ◽  
Acid Pathway

When T. pyriformis is grown in the presence of 10(-2)M-mevalonic acid, the uptake exceeds the cell's requirement for this biosynthetic intermediate. The majority of the excess mevalonic acid is diverted into ubiquinone-8 biosynthesis whereas the biosynthesis of tetrahymanol, the major product of the mevalonic acid pathway, is unchanged. In the presence of excess external mevalonic acid, the biosynthesis of mevalonic acid by the cell is inhibited. It is proposed that ubiquinone biosynthesis is normally regulated by mevalonic acid availability, whereas tetrahymanol biosynthesis is regulated primarily at a later point in the pathway.

scholarly journals Microbial biotransformation as a tool for drug development based on natural products from mevalonic acid pathway: A review

2015 ◽  
Vol 6 (1) ◽  
pp. 17-33 ◽  
Author(s):  
Mohamed-Elamir F. Hegazy ◽  
Tarik A. Mohamed ◽  
Abdelsamed I. ElShamy ◽  
Abou-El-Hamd H. Mohamed ◽  
Usama A. Mahalel ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Development ◽  
Mevalonic Acid ◽  
Mevalonic Acid Pathway ◽  
Acid Pathway

scholarly journals Peroxisomal Localization of Arabidopsis Isopentenyl Diphosphate Isomerases Suggests That Part of the Plant Isoprenoid Mevalonic Acid Pathway Is Compartmentalized to Peroxisomes

2008 ◽  
Vol 148 (3) ◽  
pp. 1219-1228 ◽  
Author(s):  
Maya Sapir-Mir ◽  
Anahit Mett ◽  
Eduard Belausov ◽  
Shira Tal-Meshulam ◽  
Ahuva Frydman ◽  
...  
Keyword(s):  
Mevalonic Acid ◽  
Isopentenyl Diphosphate ◽  
Mevalonic Acid Pathway ◽  
Acid Pathway

Genetic Studies into Musty Odor Production by Actinomycetes

1992 ◽  
Vol 25 (2) ◽  
pp. 171-176 ◽  
Author(s):  
Y. Ishibashi
Keyword(s):  
Mevalonic Acid ◽  
Aerial Mycelium ◽  
Pigment Formation ◽  
Genetic Studies ◽  
Phenotypic Characters ◽  
Taste And Odor ◽  
Mevalonic Acid Pathway ◽  
Musty Odor ◽  
Acid Pathway ◽  
Odor Production

Musty taste and odor is a serious problem for drinking water. Much data regarding its occurrence are being accumulated. However, we may be able to solve this problem by inquiring into the nature of secondary metabolism through the mevalonic acid pathway in actinomycetes and/or cyanobacteria that yield musty smelling compounds. Therefore, genetic analysis is applied to look for new solutions. By investigating Streptomyces sp. with the protocol to recover plasmid DNA, it was difficult to get the infinitesimally small covalently closed circular (ccc) plasmid. On the other hand, Streptomyces strains which have been cured, which implicates plasmids, lost phenotypic characters such as musty odor production with aerial mycelium and pigment formation. DNA in Streptomyces are unstable and often cause amplification and deletion. The existence of giant linear plasmids was detected in musty smelling strains using pulsed – field gel electrophoresis.

scholarly journals The isomiR-140-3p-regulated mevalonic acid pathway as a potential target for prevention of triple negative breast cancer

2018 ◽  
Vol 20 (1) ◽  
Author(s):  
Anjana Bhardwaj ◽  
Harpreet Singh ◽  
Celestine Marie Trinidad ◽  
Constance T. Albarracin ◽  
Kelly K. Hunt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Mevalonic Acid ◽  
Potential Target ◽  
Mevalonic Acid Pathway ◽  
Acid Pathway
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