BRCA1 affects protein phosphatase 6 signalling through its interaction with ANKRD28

2016 ◽  
Vol 473 (7) ◽  
pp. 949-960 ◽  
Author(s):  
Anne Vincent ◽  
Elise Berthel ◽  
Estelle Dacheux ◽  
Clémence Magnard ◽  
Nicole L. Dalla Venezia
Keyword(s):  
Ovarian Cancer ◽  
Protein Phosphatase ◽  
Cancer Susceptibility ◽  
Susceptibility Gene ◽  
Ankyrin Repeat ◽  
Regulatory Subunit ◽  
Breast And Ovarian Cancer ◽  
Repeat Domain ◽  
Ankyrin Repeat Domain ◽  
Cancer Susceptibility Gene

We report a novel interaction between the tumour suppressor BRCA1 (breast and ovarian cancer-susceptibility gene 1) and the PP6 (protein phosphatase 6) regulatory subunit ANKRD28 (ankyrin repeat domain 28) in the cytoplasm, and further identify BRCA1 as a novel modulator of PP6.

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

Science ◽  
1994 ◽  
Vol 266 (5182) ◽  
pp. 66-71 ◽  
Author(s):  
Y Miki ◽  
J Swensen ◽  
D Shattuck-Eidens ◽  
P. Futreal ◽  
K Harshman ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Susceptibility ◽  
Susceptibility Gene ◽  
Breast And Ovarian Cancer ◽  
Strong Candidate ◽  
Cancer Susceptibility Gene

Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene

2010 ◽  
Vol 42 (5) ◽  
pp. 410-414 ◽  
Author(s):  
Alfons Meindl ◽  
Heide Hellebrand ◽  
Constanze Wiek ◽  
Verena Erven ◽  
Barbara Wappenschmidt ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Susceptibility ◽  
Human Cancer ◽  
Susceptibility Gene ◽  
Germline Mutations ◽  
Breast And Ovarian Cancer ◽  
Cancer Susceptibility Gene
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