HOXB5 induces invasion and migration through direct transcriptional up-regulation of β-catenin in human gastric carcinoma

2015 ◽  
Vol 472 (3) ◽  
pp. 393-403 ◽  
Author(s):  
Chang-Soo Hong ◽  
Oh Jeong ◽  
Zhengri Piao ◽  
Chen Guo ◽  
Mi-Ran Jung ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastric Carcinoma ◽  
Cancer Cells ◽  
Transcriptional Expression ◽  
Gastric Cancer Cells ◽  
Migration Activity ◽  
Invasion And Migration ◽  
Human Gastric Carcinoma ◽  
And Migration

HOXB5 is significantly up-regulated in gastric cancer and its expression is closely correlated with β-catenin expression. HOXB5 binds directly to the CTNNB1 promoter and activates its transcriptional expression, which in turn promotes invasion and migration activity of gastric cancer cells.

Effects and Mechanisms of Anlotinib and Dihydroartemisinin Combination Therapy in Ameliorating Malignant Biological Behavior of Gastric Cancer Cells

2020 ◽  
Vol 21 ◽  
Author(s):  
Qiong Luo ◽  
Suyun Zhang ◽  
Donghuan Zhang ◽  
Rui Feng ◽  
Nan Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Molecular Mechanisms ◽  
Chorioallantoic Membrane ◽  
Cell Counting ◽  
Biological Behavior ◽  
Gastric Cancer Cells ◽  
Invasion And Migration ◽  
Apoptosis Related Protein ◽  
And Migration

Background: Gastric cancer(GC) is currently one of the major malignancies that threatens human lives and health. Anlotinib is a novel small-molecule that inhibits angiogenesis to exert anti-tumor effects. However, the function in gastric cancer is incompletely understood. Objective: The aim of the present study was to investigate the anti-tumor effects and molecular mechanisms of anlotinib combined with dihydroartemisinin (DHA) in SGC7901 gastric cancer cells. Method: Different concentrations of anlotinib and DHA were used to treat SGC7901 gastric cancer cells, after which cell proliferation was measured. Drug interactions of anlotinib and DHA were analyzed by the Chou-Talalay method with CompuSyn software. proliferation, apoptosis, invasion, migration, and angiogenesis were measured using the cell counting kit-8 (CCK8) assay, flow cytometry, Transwell invasion assays, scratch assays, and chicken chorioallantoic membrane (CAM) assays. proliferation-associated protein (Ki67), apoptosis-related protein (Bcl-2), and vascular endothelial growth factor A (VEGF-A) were quantified by Western bloting. Results: The combination of 2.5 μmol/L of anlotinib and 5 of μmol/L DHA was highly synergistic in inhibiting cell growth, significantly increased the apoptosis rate and suppressed obviously the invasion and migration capability and angiogenesis of gastric cancer cells. In addition, the expression levels of Ki67, Bcl-2, and VEGF-A, as well as angiogenesis, were significantly decreased in the Combination of drugs compared with in control and either drug alone. Conclusion: The combination of anlotinib and DHA showed synergistic antitumor activity, suggesting their potential in treating patients with gastric cancer.

scholarly journals miR-133b Suppresses Invasion and Migration of Gastric Cancer Cells via the COL1A1/TGF-β Axis

2020 ◽  
Vol Volume 13 ◽  
pp. 7985-7995
Author(s):  
Yuan Guo ◽  
Guochun Lu ◽  
Huahui Mao ◽  
Shengkun Zhou ◽  
Xiangmei Tong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Gastric Cancer Cells ◽  
Invasion And Migration ◽  
And Migration

scholarly journals Upregulation of circ_0066444 promotes the proliferation, invasion, and migration of gastric cancer cells

2018 ◽  
Vol Volume 11 ◽  
pp. 2753-2761 ◽  
Author(s):  
Dawei Rong ◽  
Chaoxi Dong ◽  
Kai Fu ◽  
Hanjin Wang ◽  
Weiwei Tang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Gastric Cancer Cells ◽  
Invasion And Migration ◽  
And Migration

KLF8 involves in TGF-beta-induced EMT and promotes invasion and migration in gastric cancer cells

2013 ◽  
Vol 139 (6) ◽  
pp. 1033-1042 ◽  
Author(s):  
Hui Zhang ◽  
Lili Liu ◽  
Yafang Wang ◽  
Guohong Zhao ◽  
Rougang Xie ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Tgf Beta ◽  
Gastric Cancer Cells ◽  
Invasion And Migration ◽  
And Migration

scholarly journals Metallopanstimulin-1 regulates invasion and migration of gastric cancer cells partially through integrin β4

2013 ◽  
Vol 34 (12) ◽  
pp. 2851-2860 ◽  
Author(s):  
Zhong-Yin Yang ◽  
He Jiang ◽  
Ying Qu ◽  
Min Wei ◽  
Min Yan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Gastric Cancer Cells ◽  
Invasion And Migration ◽  
Integrin Β4 ◽  
And Migration
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