scholarly journals Orphan nuclear receptor oestrogen-related receptor γ (ERRγ) plays a key role in hepatic cannabinoid receptor type 1-mediated induction of CYP7A1 gene expression

2015 ◽  
Vol 470 (2) ◽  
pp. 181-193 ◽  
Author(s):  
Yaochen Zhang ◽  
Don-Kyu Kim ◽  
Ji-Min Lee ◽  
Seung Bum Park ◽  
Won-IL Jeong ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bile Acid ◽  
Nuclear Receptor ◽  
Cannabinoid Receptor ◽  
Inverse Agonist ◽  
Receptor Type ◽  
Orphan Nuclear Receptor ◽  
Transcription Regulator ◽  
Estrogen Related Receptor

ERRγ is a novel transcription regulator of CYP7A1 (cholesterol 7α-hydroxylase). An ERRγ (Estrogen-related receptor γ) inverse agonist modulates bile acid homoeostasis via regulation of CYP7A1 gene expression.

Inverse agonist of ERRγ reduces cannabinoid receptor type 1-mediated induction of fibrinogen synthesis in mice with a high-fat diet-intoxicated liver

2018 ◽  
Vol 92 (9) ◽  
pp. 2885-2896 ◽  
Author(s):  
Yaochen Zhang ◽  
Don-Kyu Kim ◽  
Yoon Seok Jung ◽  
Yong-Hoon Kim ◽  
Yong Soo Lee ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Cannabinoid Receptor ◽  
Inverse Agonist ◽  
Receptor Type ◽  
High Fat ◽  
Cannabinoid Receptor Type 1

scholarly journals Psychosocial Stress and Cannabinoid Drugs Affect Acetylation of α-tubulin (K40) and Gene Expression in the Prefrontal Cortex of Adult Mice

2021 ◽  
Author(s):  
Jordi Tomas-Roig ◽  
Shyam Sundar Ramasamy ◽  
Diana Zbarsky ◽  
Ursula Havemann-Reinecke ◽  
Sigrid Hoyer-Fender
Keyword(s):  
Gene Expression ◽  
Prefrontal Cortex ◽  
Psychosocial Stress ◽  
Cannabinoid Receptor ◽  
Brain Plasticity ◽  
Receptor Type ◽  
Tubulin Acetylation ◽  
Cannabinoid Receptor Type 1 ◽  
The Impact

Abstract The dynamics of neuronal microtubules are essential for brain plasticity. Vesicular transport and synaptic transmission, additionally, requires acetylation of α-tubulin, and aberrant tubulin acetylation and neurobiological deficits are associated. Prolonged exposure to a stressor or consumption of drugs of abuse, like marihuana, lead to neurological changes and psychotic disorders. Here, we studied the effect of psychosocial stress and the administration of cannabinoid receptor type 1 drugs on α-tubulin acetylation in different brain regions of mice. We found significantly decreased tubulin acetylation in the prefrontal cortex and the dorsal striatum in stressed mice. The impact of cannabinoid drugs on stress-induced microtubule disturbance was investigated by administration of the cannabinoid receptor agonist WIN55,212-2 and/or antagonist rimonabant. In both, control and stressed mice, the administration of WIN55,212-2 significantly increased the tubulin acetylation in the prefrontal cortex whereas administration of both cannabinoid drugs acted antagonistically indicating a cannabinoid receptor type 1 mediated effect. The analysis of gene expression in the prefrontal cortex showed a consistent expression of ApoE attributable to either psychosocial stress or administration of the cannabinoid agonist. Additionally, ApoE expression inversely correlated with acetylated tubulin levels when comparing controls and stressed mice treated with WIN55,212-2 whereas rimonabant treatment showed the opposite.

scholarly journals Hepatic Cannabinoid Receptor Type 1 Mediates Alcohol-Induced Regulation of Bile Acid Enzyme Genes Expression Via CREBH

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e68845 ◽  
Author(s):  
Dipanjan Chanda ◽  
Yong-Hoon Kim ◽  
Tiangang Li ◽  
Jagannath Misra ◽  
Don-Kyu Kim ◽  
...  
Keyword(s):  
Bile Acid ◽  
Cannabinoid Receptor ◽  
Receptor Type ◽  
Cannabinoid Receptor Type 1 ◽  
Genes Expression

Identification of a Selective Inverse Agonist for the Orphan Nuclear Receptor Estrogen-Related Receptor α

2004 ◽  
Vol 47 (23) ◽  
pp. 5593-5596 ◽  
Author(s):  
Brett B. Busch ◽  
William C. Stevens, ◽  
Richard Martin ◽  
Peter Ordentlich ◽  
Sihong Zhou ◽  
...  
Keyword(s):  
Nuclear Receptor ◽  
Inverse Agonist ◽  
Orphan Nuclear Receptor ◽  
Estrogen Related Receptor

scholarly journals Orphan Nuclear Receptor ERRγ Is a Transcriptional Regulator of CB1 Receptor-Mediated TFR2 Gene Expression in Hepatocytes

2021 ◽  
Vol 22 (11) ◽  
pp. 6021
Author(s):  
Bo-Eun Kim ◽  
Byungyoon Choi ◽  
Woo-Ram Park ◽  
Yu-Ji Kim ◽  
In-Young Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcriptional Regulation ◽  
Nuclear Receptor ◽  
Gene Transcription ◽  
Cannabinoid Receptor ◽  
Gene Promoter ◽  
Cb1 Receptor ◽  
Orphan Nuclear Receptor ◽  
Endocrine Control ◽  
Hepatic Iron Overload

Orphan nuclear receptor estrogen-related receptor γ (ERRγ) is an important transcription factor modulating gene transcription involved in endocrine control of liver metabolism. Transferrin receptor 2 (TFR2), a carrier protein for transferrin, is involved in hepatic iron overload in alcoholic liver disease (ALD). However, TFR2 gene transcriptional regulation in hepatocytes remains largely unknown. In this study, we described a detailed molecular mechanism of hepatic TFR2 gene expression involving ERRγ in response to an endocannabinoid 2-arachidonoylglycerol (2-AG). Treatment with 2-AG and arachidonyl-2′-chloroethylamide, a selective cannabinoid receptor type 1 (CB1) receptor agonist, increased ERRγ and TFR2 expression in hepatocytes. Overexpression of ERRγ was sufficient to induce TFR2 expression in both human and mouse hepatocytes. In addition, ERRγ knockdown significantly decreased 2-AG or alcohol-mediated TFR2 gene expression in cultured hepatocytes and mouse livers. Finally, deletion and mutation analysis of the TFR2 gene promoter demonstrated that ERRγ directly modulated TFR2 gene transcription via binding to an ERR-response element. This was further confirmed by chromatin immunoprecipitation assay. Taken together, these results reveal a previously unrecognized role of ERRγ in the transcriptional regulation of TFR2 gene expression in response to alcohol.

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