The solution structure of the MANEC-type domain from hepatocyte growth factor activator inhibitor-1 reveals an unexpected PAN/apple domain-type fold

2015 ◽  
Vol 466 (2) ◽  
pp. 299-309 ◽  
Author(s):  
Zebin Hong ◽  
Michal Nowakowski ◽  
Chris Spronk ◽  
Steen V. Petersen ◽  
Peter A. Andreasen ◽  
...  
Keyword(s):  
Solution Structure ◽  
3D Structure ◽  
Reference Structure ◽  
Domain Family ◽  
Domain Type ◽  
Hepatocyte Growth Factor Activator ◽  
Apple Domain ◽  
Hepatocyte Growth ◽  
Activator Inhibitor

The first 3D structure and characterization of a MANEC domain is presented, defining MANEC as a new subclass of the PAN/apple domain family. The structure is a key to understanding HAI-1 function and a reference-structure for the >400 MANEC-containing proteins.

Expression of hepatocyte growth factor activator inhibitor type 1 in endothelial cells

Human Cell ◽  
2006 ◽  
Vol 19 (3) ◽  
pp. 91-97 ◽  
Author(s):  
Yutaka Akiyama ◽  
Miyuki Nagai ◽  
Wataru Komaki ◽  
Kousuke Marutsuka ◽  
Yujiro Asada ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Hepatocyte Growth Factor Activator ◽  
Inhibitor Type ◽  
Activator Inhibitor Type ◽  
Hepatocyte Growth ◽  
Activator Inhibitor
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