Steatosis inhibits liver cell store-operated Ca2+ entry and reduces ER Ca2+ through a protein kinase C-dependent mechanism

2015 ◽  
Vol 466 (2) ◽  
pp. 379-390 ◽  
Author(s):  
Claire H. Wilson ◽  
Eunüs S. Ali ◽  
Nathan Scrimgeour ◽  
Alyce M. Martin ◽  
Jin Hua ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Liver Cell ◽  
Lipid Droplets ◽  
Liver Steatosis ◽  
Liver Cells ◽  
Steatotic Liver ◽  
Kinase C ◽  
Ca2 Channels ◽  
Dependent Mechanism

Ca2+ entry through SOCs (store-operated Ca2+ channels; SOCE) is substantially inhibited in steatotic liver cells through a mechanism involving protein kinase C (PKC). Inhibition of Ca2+ entry enhances the accumulation of cytoplasmic lipid droplets and may contribute to the development of liver steatosis.

MAC-1 mediates adherence of human monocytes to endothelium via a protein kinase C dependent mechanism

1990 ◽  
Vol 1052 (1) ◽  
pp. 166-172 ◽  
Author(s):  
Ann-Marie Gladwin ◽  
David G. Hassall ◽  
John F. Martin ◽  
Robert F.G. Booth
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Human Monocytes ◽  
Kinase C ◽  
Dependent Mechanism

Oxytocin activates calcium signaling in rat sensory neurons through a protein kinase C-dependent mechanism

2013 ◽  
Vol 70 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Ahmet Ayar ◽  
Mete Ozcan ◽  
Ergul Alcin ◽  
Ihsan Serhatlioglu ◽  
Sibel Ozcan ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Calcium Signaling ◽  
Sensory Neurons ◽  
Kinase C ◽  
Dependent Mechanism
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