Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor

2014 ◽  
Vol 465 (1) ◽  
pp. 163-173 ◽  
Author(s):  
Vidhu Sharma ◽  
Preety Panwar ◽  
Anthony J. O’Donoghue ◽  
Haoran Cui ◽  
Rafael V. C. Guido ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Extracellular Matrix Proteins ◽  
Cathepsin K ◽  
Selective Inhibition ◽  
Matrix Proteins ◽  
Elastase Activity ◽  
Structural Requirements ◽  
Proteolytic Activities

The degradation of extracellular matrix proteins such as elastin and collagen by cathepsin K is selectively regulated by exosites. A specific exosite inhibitor blocks the collagenase and elastase activity without interfering with other proteolytic activities.

Extracellular matrix proteins control the growth of cerebellar medulloblastoma cells

2004 ◽  
Vol 216 (03) ◽  
Author(s):  
U Schüller ◽  
W Hartmann ◽  
A Koch ◽  
K Schilling ◽  
OD Wiestler ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Cerebellar Medulloblastoma

scholarly journals Binding of human syndecan to extracellular matrix proteins.

1990 ◽  
Vol 265 (29) ◽  
pp. 17837-17843 ◽  
Author(s):  
K Elenius ◽  
M Salmivirta ◽  
P Inki ◽  
M Mali ◽  
M Jalkanen
Keyword(s):  
Extracellular Matrix ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins

Impact of cyclic mechanical stimulation on the expression of extracellular matrix proteins in human primary rotator cuff fibroblasts

2015 ◽  
Vol 24 (12) ◽  
pp. 3884-3891 ◽  
Author(s):  
Birgit Lohberger ◽  
Heike Kaltenegger ◽  
Nicole Stuendl ◽  
Beate Rinner ◽  
Andreas Leithner ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Rotator Cuff ◽  
Mechanical Stimulation ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins
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