Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism

2014 ◽  
Vol 461 (2) ◽  
pp. 205-212 ◽  
Author(s):  
Nafisa M. Jadavji ◽  
Renata H. Bahous ◽  
Liyuan Deng ◽  
Olga Malysheva ◽  
Marilyn Grand’maison ◽  
...  
Keyword(s):  
Mouse Model ◽  
Memory Impairment ◽  
Short Term Memory ◽  
Methionine Synthase ◽  
Dna Hypomethylation ◽  
Short Term ◽  
Term Memory ◽  
Methionine Synthase Reductase ◽  
Choline Metabolism ◽  
Mild Hyperhomocysteinaemia

Mice with mild hyperhomocysteinaemia due to methionine synthase reductase deficiency have impairments in short-term memory. DNA hypomethylation and compensatory disturbances in choline metabolism in the hippocampus lead to decreased levels of acetylcholine, a critical neurotransmitter in learning and memory.

scholarly journals Phonological Short-Term Memory Impairment in Children with Down Syndrome

2021 ◽  
Vol 89 (6) ◽  
pp. 897-902
Author(s):  
EMAN F. EL-WAKIL, M.D.; RASHA M. SHOEIB, M.D. ◽  
YOSSRA A.N. SALLAM, M.D.; MAHA H. BOSHNAQ, M.D.
Keyword(s):  
Down Syndrome ◽  
Memory Impairment ◽  
Short Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Children With Down Syndrome

scholarly journals Short‐term memory impairment in vestibular patients can arise independently of psychiatric impairment, fatigue, and sleeplessness

2018 ◽  
Vol 13 (3) ◽  
pp. 417-431 ◽  
Author(s):  
Laura Smith ◽  
David Wilkinson ◽  
Mayur Bodani ◽  
Rowena Bicknell ◽  
S. S. Surenthiran
Keyword(s):  
Memory Impairment ◽  
Short Term Memory ◽  
Short Term ◽  
Term Memory

Clinical diagnosis of LGI1 antibody encephalitis in an 83-year-old woman

2021 ◽  
Vol 14 (1) ◽  
pp. e237398
Author(s):  
Jonathan E Attwood ◽  
Saniya Naseer ◽  
Sophia Michael ◽  
Josie Riley
Keyword(s):  
Cognitive Impairment ◽  
Clinical Diagnosis ◽  
Memory Impairment ◽  
Short Term Memory ◽  
Autoimmune Encephalitis ◽  
Short Term ◽  
Term Memory ◽  
Blood Tests ◽  
Abnormal Movements ◽  
History Of

An 83-year-old woman was referred to hospital with a 2-week history of short-lived episodic unpleasant sensations in her head and running down her body. This was accompanied by new short-term memory impairment and arm spasms. Initial investigations including blood tests and brain imaging did not reveal the diagnosis. The patient developed an increasing frequency of abnormal movements of her face and arm. These were clinically recognised as faciobrachial dystonic seizures (FBDS). FBDS are pathognomonic of an autoimmune encephalitis caused by an antibody directed against leucine-rich glioma-inactivated 1 (LGI1). The clinical diagnosis resulted in treatment with immunotherapy, leading to cessation of seizures and rapid cognitive recovery. Later, the predicted serology was confirmed. This reversible and under-recognised cause of cognitive impairment, typically affecting elderly patients, can be diagnosed clinically to enable early and effective treatment.

scholarly journals Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions

2018 ◽  
Vol 28 (9) ◽  
pp. 1474-1486 ◽  
Author(s):  
Thomas Arbogast ◽  
Parisa Razaz ◽  
Jacob Ellegood ◽  
Spencer U McKinstry ◽  
Serkan Erdin ◽  
...  
Keyword(s):  
Memory Impairment ◽  
Short Term Memory ◽  
Genetic Interactions ◽  
Short Term ◽  
Term Memory ◽  
Deficient Mice
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