Type AII lantibiotic bovicin HJ50 with a rare disulfide bond: structure, structure–activity relationships and mode of action

2014 ◽  
Vol 461 (3) ◽  
pp. 497-508 ◽  
Author(s):  
Jie Zhang ◽  
Yingang Feng ◽  
Kunling Teng ◽  
Yuheng Lin ◽  
Yong Gao ◽  
...  
Keyword(s):  
Spatial Structure ◽  
Disulfide Bond ◽  
Mode Of Action ◽  
Pore Formation ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Antimicrobial Mechanism

The first spatial structure of type AII lantibiotics has been resolved, indicating that the globular region is still flexible. A novel antimicrobial mechanism of this type involving pore formation is elucidated, which is related with the rare disulfide bond in lantibiotics.

scholarly journals Characterizing the structure–activity relationships of natural products, tanshinones, reveals their mode of action in inhibiting spleen tyrosine kinase

RSC Advances ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 2453-2461
Author(s):  
Min-Che Tung ◽  
Keng-Chang Tsai ◽  
Kit-Man Fung ◽  
Ming-Jaw Don ◽  
Tien-Sheng Tseng
Keyword(s):  
Natural Products ◽  
Protein Kinase ◽  
Tyrosine Kinase ◽  
Mode Of Action ◽  
Drug Target ◽  
Receptor Protein ◽  
Inflammatory Disorder ◽  
Spleen Tyrosine Kinase ◽  
Structure Activity Relationships ◽  
Structure Activity

The cytosolic non-receptor protein kinase, spleen tyrosine kinase (SYK), is an attractive drug target in autoimmune, inflammatory disorder, and cancers indications.

Perspective on FTY720, an Immunosuppressant

Synthesis ◽  
2018 ◽  
Vol 50 (05) ◽  
pp. 968-983 ◽  
Author(s):  
Sivaraman Balasubramaniam ◽  
Ganapathy Sankaran ◽  
Sneh Badle
Keyword(s):  
Chemical Modification ◽  
Mode Of Action ◽  
Immunosuppressive Drugs ◽  
Binding Studies ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Fingolimod Hydrochloride

FTY720 {fingolimod hydrochloride, 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride}, a novel immunosuppressant, was discovered by chemical modification based on the structure activity relationships of ISP-I (myriocin), a metabolite of the fungus Isaria­ sinclairii. This short perspective provides insights to the various strategies available in the literature for the synthesis of FTY720 and its analogues.1 Introduction2 Classification of Immunosuppressive Drugs3 The Rise of FTY7204 Different Synthetic Strategies for FTY7205 Analogues of FTY7206 Binding Studies of FTY7207 Mode of Action8 Conclusion

Spasmolytic Effects, Mode of Action, and Structure−Activity Relationships of Stilbenoids fromNidema boothii†,⊥

2004 ◽  
Vol 67 (2) ◽  
pp. 160-167 ◽  
Author(s):  
Yanet Hernández-Romero ◽  
Juana-Isela Rojas ◽  
Rafael Castillo ◽  
Alejandra Rojas ◽  
Rachel Mata
Keyword(s):  
Mode Of Action ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals Structure-Activity Relationships of the Antimicrobial Peptide Arasin 1 — And Mode of Action Studies of the N-Terminal, Proline-Rich Region

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e53326 ◽  
Author(s):  
Victoria S. Paulsen ◽  
Hans-Matti Blencke ◽  
Monica Benincasa ◽  
Tor Haug ◽  
Jacobus J. Eksteen ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Mode Of Action ◽  
Rich Region ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Proline Rich Region
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