scholarly journals Mature VLDL triggers the biogenesis of a distinct vesicle from the trans-Golgi network for its export to the plasma membrane

2014 ◽  
Vol 459 (1) ◽  
pp. 47-58 ◽  
Author(s):  
Tanvir Hossain ◽  
Aladdin Riad ◽  
Shaila Siddiqi ◽  
Sampath Parthasarathy ◽  
Shadab A. Siddiqi
Keyword(s):  
Plasma Membrane ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Very Low Density Lipoproteins ◽  
Trans Golgi Network ◽  
Golgi Transport ◽  
Golgi Network ◽  
Insight Into

We have identified a novel vesicle that transports mature very-low-density lipoproteins from the trans-Golgi network to the plasma membrane. Identification of this vesicle provides new insight into the mechanism that regulates the post-Golgi transport of mature very-low-density lipoproteins.

scholarly journals Furin and proprotein convertase 7 (PC7)/lymphoma PC endogenously expressed in rat liver can be resolved into distinct post-Golgi compartments

1998 ◽  
Vol 336 (2) ◽  
pp. 311-316 ◽  
Author(s):  
Sandrine WOUTERS ◽  
Michèle LERUTH ◽  
Etienne DECROLY ◽  
Michel VANDENBRANDEN ◽  
John W. M. CREEMERS ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Rat Liver ◽  
Subcellular Fractionation ◽  
Low Density Lipoproteins ◽  
Considerable Proportion ◽  
Low Density ◽  
Proprotein Convertase ◽  
Very Low Density Lipoproteins ◽  
Golgi Network ◽  
Intracellular Compartmentalization

The intracellular compartmentalization in rat liver of the membrane-associated convertases furin and proprotein convertase 7 (PC7)/lymphoma PC (LPC) was investigated by analytical subcellular fractionation. In control animals, both enzymes were found to localize in fractions depleted of endoplasmic reticulum, cis-Golgi and lysosomal markers, but to co-distribute with the Golgi marker galactosyltransferase and the trans-Golgi network (TGN) marker TGN38. After overloading Golgi-derived vesicles with very-low-density lipoproteins (VLDL) by feeding rats with ethanol, the distribution of PC7/LPC was shifted markedly towards lower densities, in contrast with those of furin and the TGN marker. This provides support for the TGN localization of endogenously expressed furin and indicates that, at steady state, a considerable proportion of PC7/LPC may be associated with vesicles derived from the TGN.

scholarly journals Studies of the Proteins in Human Plasma Very Low Density Lipoproteins

1969 ◽  
Vol 244 (20) ◽  
pp. 5687-5694 ◽  
Author(s):  
W. Virgil Brown ◽  
Robert I. Levy ◽  
Donald S. Fredrickson
Keyword(s):  
Human Plasma ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Very Low Density Lipoproteins
Sign in / Sign up

Export Citation Format

Share Document