TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt

2013 ◽  
Vol 455 (2) ◽  
pp. 207-216 ◽  
Author(s):  
Kenneth K. Y. Cheng ◽  
Karen S. L. Lam ◽  
Yu Wang ◽  
Donghai Wu ◽  
Mingliang Zhang ◽  
...  
Keyword(s):  
Hepatic Glucose Production ◽  
Adaptor Protein ◽  
Glucose Production ◽  
Membrane Localization ◽  
Dependent Manner ◽  
Membrane Translocation ◽  
Insulin Stimulation ◽  
Akt Activation ◽  
Hepatic Glucose ◽  
Impaired Insulin

The adaptor protein APPL1 undergoes ubiquitination upon insulin stimulation in a TRAF6-dependent manner. Abrogation of APPL1 ubiquitination blocks insulin-evoked membrane localization of the APPL1–Akt complex, leading to impaired insulin actions on Akt activation and suppression of hepatic glucose production.

scholarly journals APPL1 Potentiates Insulin-Mediated Inhibition of Hepatic Glucose Production and Alleviates Diabetes via Akt Activation in Mice

2009 ◽  
Vol 9 (5) ◽  
pp. 417-427 ◽  
Author(s):  
Kenneth K.Y. Cheng ◽  
Miguel A. Iglesias ◽  
Karen S.L. Lam ◽  
Yu Wang ◽  
Gary Sweeney ◽  
...  
Keyword(s):  
Hepatic Glucose Production ◽  
Glucose Production ◽  
Akt Activation ◽  
Hepatic Glucose

scholarly journals Glucagon regulates hepatic mitochondrial function and biogenesis through FOXO1

2019 ◽  
Vol 241 (3) ◽  
pp. 265-278
Author(s):  
Wanbao Yang ◽  
Hui Yan ◽  
Quan Pan ◽  
James Zheng Shen ◽  
Fenghua Zhou ◽  
...  
Keyword(s):  
Glucose Homeostasis ◽  
Mitochondrial Function ◽  
Hepatic Glucose Production ◽  
Glucose Production ◽  
Complex Iii ◽  
Dependent Manner ◽  
Hepatic Glucose ◽  
Patients With Diabetes ◽  
High Level

Glucagon promotes hepatic glucose production maintaining glucose homeostasis in the fasting state. Glucagon maintains at high level in both diabetic animals and human, contributing to hyperglycemia. Mitochondria, a major place for glucose oxidation, are dysfunctional in diabetic condition. However, whether hepatic mitochondrial function can be affected by glucagon remains unknown. Recently, we reported that FOXO1 is an important mediator in glucagon signaling in control of glucose homeostasis. In this study, we further assessed the role of FOXO1 in the action of glucagon in the regulation of hepatic mitochondrial function. We found that glucagon decreased the heme production in a FOXO1-dependent manner, suppressed heme-dependent complex III (UQCRC1) and complex IV (MT-CO1) and inhibited hepatic mitochondrial function. However, the suppression of mitochondrial function by glucagon was largely rescued by deleting the Foxo1 gene in hepatocytes. Glucagon tends to reduce hepatic mitochondrial biogenesis by attenuating the expression of NRF1, TFAM and MFN2, which is mediated by FOXO1. In db/db mice, we found that hepatic mitochondrial function was suppressed and expression levels of UQCRC1, MT-CO1, NRF1 and TFAM were downregulated in the liver. These findings suggest that hepatic mitochondrial function can be impaired when hyperglucagonemia occurs in the patients with diabetes mellitus, resulting in organ failure.

FoxO3 regulates hepatic glucose production

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
S Gul ◽  
KH Holzmann ◽  
F Leithäuser ◽  
H Maier ◽  
B Böhm ◽  
...  
Keyword(s):  
Hepatic Glucose Production ◽  
Glucose Production ◽  
Hepatic Glucose

Hyperglycemia per se does not inhibit hepatic glucose production in man

1989 ◽  
Vol 120 (3_Suppl) ◽  
pp. S20
Author(s):  
M.J. MÜLLER ◽  
K.J. ACHESON ◽  
A. G. BURGER ◽  
E. JEQUIER ◽  
A. VON ZUR MÜHLEN
Keyword(s):  
Hepatic Glucose Production ◽  
Glucose Production ◽  
Hepatic Glucose ◽  
Per Se

Regulation of Hepatic Glucose Production by Transforming Growth Factor Beta 1 via Protein Kinase A

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2441-PUB ◽  
Author(s):  
QUAN PAN ◽  
YUNMEI CHEN ◽  
HUI YAN ◽  
WANBAO YANG ◽  
ZHENG SHEN ◽  
...  
Keyword(s):  
Growth Factor ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Hepatic Glucose Production ◽  
Glucose Production ◽  
Hepatic Glucose ◽  
Growth Factor Beta ◽  
Kinase A

64-LB: Aerobic Exercise Decreases Hepatic Glucose Production via Asprosin Pathway in Diabetic Rats

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 64-LB
Author(s):  
JEONGRIM KO ◽  
TAE NYUN KIM ◽  
DAE YUN SEO ◽  
JIN HAN
Keyword(s):  
Aerobic Exercise ◽  
Hepatic Glucose Production ◽  
Glucose Production ◽  
Diabetic Rats ◽  
Hepatic Glucose
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