scholarly journals The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4

2009 ◽  
Vol 419 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Pamela J. Plant ◽  
Judy Correa ◽  
Neil Goldenberg ◽  
James Bain ◽  
Jane Batt
Keyword(s):  
Ubiquitin Ligase ◽  
Biological Process ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell ◽  
Related Protein ◽  
Inositol Phosphatase ◽  
Late Endosomes ◽  
Muscle Breakdown ◽  
Novel Target

The inositol phosphatase, MTMR4 (myotubularin-related protein 4), was identified as a novel interactor of the ubiquitin ligase Nedd4 (neural-precursor-cell-expressed developmentally down-regulated 4). hMTMR4 (human MTMR4) and Nedd4 co-immunoprecipitated and co-localized to late endosomes. The PY (Pro-Tyr) motif of hMTMR4 binds to WW (Trp-Trp) domains of hNedd4. MTMR4 expression was decreased in atrophying muscle, whereas Nedd4 expression was increased and hMTMR4 was ubiquitinated by hNedd4, suggesting that this novel interaction may underlie the biological process of muscle breakdown.

PDLIM7 is a novel target of the ubiquitin ligase Nedd4-1 in skeletal muscle

2016 ◽  
Vol 473 (3) ◽  
pp. 267-276 ◽  
Author(s):  
Robert D'Cruz ◽  
Pamela J. Plant ◽  
Lesley A. Pablo ◽  
Shouzhe Lin ◽  
Joshua Chackowicz ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Ubiquitin Ligase ◽  
Muscle Wasting ◽  
Precursor Cell ◽  
Skeletal Muscle Atrophy ◽  
Neural Precursor ◽  
Neural Precursor Cell ◽  
Ww Domains ◽  
Novel Target ◽  
Py Motif

Nedd4-1 (neural precursor cell-expressed developmentally down-regulated 4-1) mediates skeletal muscle atrophy. We identify PDLIM7 as a novel Nedd4-1 substrate, binding Nedd4-1 WW domains via its PY motif and co-localizing with Nedd4-1 in myotubes. The interaction results in PDLIM7 ubiquitination and may underlie Nedd4-1-mediated muscle wasting.

Serum- and Glucocorticoid-Regulated Kinase 1 Regulates Ubiquitin Ligase Neural Precursor Cell-Expressed, Developmentally Down-Regulated Protein 4-2 by Inducing Interaction with 14-3-3

2005 ◽  
Vol 19 (12) ◽  
pp. 3073-3084 ◽  
Author(s):  
Vivek Bhalla ◽  
Dorothée Daidié ◽  
Hongyan Li ◽  
Alan C. Pao ◽  
Lila P. LaGrange ◽  
...  
Keyword(s):  
Ubiquitin Ligase ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell

scholarly journals Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers

2021 ◽  
Vol 11 ◽  
Author(s):  
Shangdan Xie ◽  
Lu Xia ◽  
Yizuo Song ◽  
Hejing Liu ◽  
Zhi-wei Wang ◽  
...  
Keyword(s):  
Ubiquitin Ligase ◽  
Therapeutic Strategy ◽  
Potential Role ◽  
E3 Ubiquitin Ligase ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell ◽  
Cancer Types ◽  
Clinical Drugs

Neural precursor cell expressed developmentally downregulated 4-like (NEDD4L) is an E3 ubiquitin ligase that has been reported to participate in multiple cellular procedures by regulating of substrate ubiquitination and subsequent protein degradation. A great amount of evidence has demonstrated that NEDD4L mainly functions as a tumor suppressor in most cancer types, while it also acts as an oncogene in a few cancers. In this review, we summarize the potential role of NEDD4L in carcinogenesis and the related underlying molecular mechanism to improve our understanding of its functions in the tumorigenesis of human malignancies. Developing clinical drugs targeting NEDD4L could be a potential therapeutic strategy for cancer therapy in the future.

scholarly journals Regulation of cancer-related pathways by protein NEDDylation and strategies for the use of NEDD8 inhibitors in the clinic

2014 ◽  
Vol 22 (1) ◽  
pp. T55-T70 ◽  
Author(s):  
Naima Abidi ◽  
Dimitris P Xirodimas
Keyword(s):  
Therapeutic Intervention ◽  
Biological Process ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell ◽  
Post Translational Modification ◽  
Recent Advances

Post-translational modification of proteins with ubiquitin and ubiquitin-like molecules (UBLs) controls a vast if not every biological process in the cell. It is not surprising that deregulation in ubiquitin and UBL signalling has been implicated in the pathogenesis of many diseases and that these pathways are considered as major targets for therapeutic intervention. In this review, we summarise recent advances in our understanding of the role of the UBL neural precursor cell expressed developmentally downregulated-8 (NEDD8) in cancer-related processes and potential strategies for the use of NEDD8 inhibitors as chemotherapeutics.

A Review of Bioreactor Protocols for Human Neural Precursor Cell Expansion in Preparation for Clinical Trials

2011 ◽  
Vol 6 (3) ◽  
pp. 229-254 ◽  
Author(s):  
Behnam A. Baghbaderani ◽  
Karim Mukhida ◽  
Murray Hong ◽  
Ivar Mendez ◽  
Leo A. Behie
Keyword(s):  
Clinical Trials ◽  
Cell Expansion ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell

Sonic Hedgehog Regulation of the Neural Precursor Cell Fate During Chicken Optic Tectum Development

2017 ◽  
Vol 64 (2) ◽  
pp. 287-299 ◽  
Author(s):  
Ciqing Yang ◽  
Xiaoying Li ◽  
Qiuling Li ◽  
Han Li ◽  
Liang Qiao ◽  
...  
Keyword(s):  
Cell Fate ◽  
Sonic Hedgehog ◽  
Optic Tectum ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell

Neural precursor cell influences on blood–brain barrier characteristics in rat brain endothelial cells

2007 ◽  
Vol 1159 ◽  
pp. 67-76 ◽  
Author(s):  
Joseph C. Lim ◽  
Adam J. Wolpaw ◽  
Maeve A. Caldwell ◽  
Stephen B. Hladky ◽  
Margery A. Barrand
Keyword(s):  
Endothelial Cells ◽  
Rat Brain ◽  
Blood Brain Barrier ◽  
Precursor Cell ◽  
Brain Barrier ◽  
Neural Precursor ◽  
Brain Endothelial Cells ◽  
Neural Precursor Cell ◽  
Blood Brain ◽  
Rat Brain Endothelial Cells

Bioengineering Protocols for Neural Precursor Cell Expansion

2009 ◽  
pp. 105-123 ◽  
Author(s):  
Behnam A. Baghbaderani ◽  
Arindom Sen ◽  
Michael S. Kallos ◽  
Leo A. Behie
Keyword(s):  
Cell Expansion ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell
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